Biomedical subjects
A B Brosof
Publications and source records attributed to A B Brosof.
A lower dose regimen for cephradine capsules in the treatment of urinary tract infections.
In this double-blind, randomized, multicenter trial, an oral dosing regimen of 500 mg twice daily (BID) of cephradine was evaluated for the treatment of acute uncomplicated urinary tract infections due to susceptible pathogens. This dose was compared to the already established cephradine regimen of 1,000 mg BID. Of the 218 cases entered into the study, 130 were evaluable for efficacy, 64 in the 500-mg BID group and 66 in the 1,000-mg BID group. There was no statistically significant difference between the two dosage regimens regarding rapidity of clinical improvement, eradication of the pathogens, and overall therapeutic outcome. Successful responses were obtained in 89.1% of the 500-mg BID cases and in 87.9% of the 1,000-mg BID cases. These results demonstrate the safety and efficacy of a 500-mg BID dosing regimen of cephradine for this use. This regimen offers the advantages of convenience, potentially improved compliance, and cost economy.
Five-day therapy with cephradine capsules, 500 mg BID, for the treatment of acute, uncomplicated urinary tract infections.
This double-blind, randomized multi-center study compared the efficacy and safety of a five-day treatment regimen with that of a ten-day treatment regimen for acute, uncomplicated urinary tract infections. All patients received cephradine capsules, 500 mg BID. Efficacy was evaluated in 71 patients (38 with five days of treatment; 33 with ten days of treatment). All but one patient in each group had a rapid resolution of symptoms. At the completion of treatment, cephradine eradicated the causative pathogen in 97.4% and 96.9% of patients in the two groups, respectively. One week after therapy, 86.8% of patients in the five-day treatment group and 84.8% of those in the ten-day treatment group maintained both complete resolution of symptoms and bacterial eradication. The incidence of side effects was equally low in the two groups. Thus a five-day regimen of cephradine, 500 mg BID, offers the potential advantages of cost-efficiency and improved patient compliance, while maintaining clinical efficacy in treating acute, uncomplicated urinary tract infections.
Radiographic appearance of the chest following extended field radiation therapy for Hodgkin's disease. A consideration of time-dose relationships.
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