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Biomedical subjects

A B Chernomordik

Publications and source records attributed to A B Chernomordik.

At least 37 records · Page 2Linked to original sources
PubMed1980

[Use of paper strips impregnated with antibiotics in the bacteriological diagnosis of dysentery: the 2-strip method].

The studies provided development of a new method consisting of placing 2 filter paper strips each impregnated with an antibiotic (2 antibiotics are used out of 3: levomycetin, tetracycline and streptomycin) under a layer of Ploskirev's medium with sodium sulfacyl. The antibiotics are chosen proceeding from the predominance in the given area of Shigella resistant to some of the above antibiotics. The method simplifies and makes more economic the tests, provides higher frequency of Shigella isolation as compared to the procedure with the routine Ploskirev's medium or gradient dishes, has almost the same isolation frequency as with the use of 2 plates (with and without antibiotic). The method is recommended for wide use in practice.

Bacteriological Techniques↗
PubMed1979

[Results of testing a new method of using antibiotics in nutrient media for the isolation of Shigella: the 2-streak method].

A new variant of media with antibiotics for isolation of Shigella, i.e. a method of 2 streaks each containing different antibiotics was tested in analysis of excrements from patients with acute dysentery. It was found that the new method is more effective than the well known method of gradient plates (isolation of Shigella in one series of the experiments amounted to 85.2 and 64.7 per cent respectively, and in the other series of the experiments the respective figures were 95.4 and 89.3 per cent). Its efficiency was lower as compared to the procedure of inoculation onto 2 plates, i.e. onto the media with and without an antibiotic (isolation of Shigella was 67.5 and 77.4 per cent respectively). The new method provided a higher frequency of Shigella isolation as compared to inoculation onto the media without an antibiotic, as well as onto any of the media used with one antibiotic. The method of 2 streaks offers wider possibilities for choosing the antibiotics for adding to the nutrient medium, as well as estimation of the antibioticograms and species structures of Shigella distributed in a concrete area.

Anti-Bacterial Agents↗
PubMed1976

[Development of drug resistance and the cross resistance in Shigella to certain chemotherapeutic preparations in vitro].

A total of 700 Shigella cultures isolated in different regions of the Ukraine in 1974 and occasionally in 1971-1973 were studied. No cultures resistant to furazolidone or enteroseptol were found. Under the experimental conditions resistance to nitrofuran and especially oxycholine preparations in Shigella developed slowly when the cultures were passaged in broths with increasing concentrations of the drugs. Cross resistance in Shigella was observed with respect to (a) various nitrofuran preparations, less pronounced with respect to furacryline and (b) enteroseptol and 5-NOK. No cross resistance was noted between the above groups of the chemotherapeutics and levomycetin and tetracycline. 5-NOK inhibited the resistance development to streptomycin, while enteroseptol inhibited the development of resistance to furazolidone in Shigella. The studies showed that in the near future there will be observed no mass development of resistance to furazolidone and enteroseptol in Shigella.

Clioquinol↗