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Biomedical subjects

A B Koller

Publications and source records attributed to A B Koller.

15 recordsLinked to original sources
PubMed2000

Management of uterine Müllerian adenosarcoma with extrauterine metastatic deposits.

OBJECTIVE: The aim of this study was to provide the management and outcome of three patients who presented with uterine Müllerian adenosarcoma associated with extrauterine metastases. METHODS: A retrospective study of three patients who were referred to our hospital was performed. One patient was referred because of vaginal metastatic deposits that were noted during investigations for primary infertility. The other two were referred because of abnormal vaginal bleeding; one of these had a large polyp protruding through her cervix into the vagina. RESULTS: In two patients the preoperative diagnosis and extent of their disease were known while in the third patient the diagnosis was only made postoperatively. All patients had a type II radical abdominal hysterectomy, bilateral salpingo-oophorectomy, and omentectomy. Two patients were given three cycles of neoadjuvant chemotherapy and pelvic irradiation over 12 weeks. Both of these patients had their diagnosis made preoperatively and the chemotherapy consisted of 240 mg/m(2) carboplatin and 80 mg/m(2) farmorubicin per cycle. The pelvic irradiation consisted of daily fractions of 1.8-Gy irradiation to a total of 45 Gy over the first 6 weeks. The other patient was given the same regime postoperatively. All patients are still alive and free of disease between 34 and 56 months. CONCLUSION: Radical surgery, chemotherapy, and irradiation provide a management option with seemingly favorable outcome for patients with uterine Müllerian adenosarcoma associated with extrauterine metastases.

Adenosarcoma↗
PubMed1991

Takayasu's arteritis in a pregnant woman. A case report.

Takayasu's arteritis in a pregnant white patient is described. This case highlights the fact that, irrespective of race, any patient who presents for the first time in pregnancy with pulseless hypertensive disease or other features suggestive of Takayasu's arteritis, should have their management in labour determined by the number of complications that are present. These are retinopathy, arterial aneurysms, hypertension and aortic regurgitation. These prognostic criteria will result in a classification of patients that will lead to appropriate management.

Adult↗
PubMed1987

Hydatidiform mole with a coexistent live fetus. A case report.

A patient with a hydatidiform mole and coexistent live fetus is presented. This rare phenomenon occurs in 0.005-0.01% of all pregnancies. Correct antenatal diagnosis can be made with ultrasonography in conjunction with the presence of low human placental lactogen and raised beta-human chorionic gonadotrophin levels.

Adult↗
PubMed1987

Von Willebrand's disease in pregnancy. A case report.

A 30-year-old woman with von Willebrand's disease completed her third pregnancy uneventfully. She was infused during labour with fresh frozen plasma and cryoprecipitate. This is in keeping with the good outcome reported in the literature when management is appropriate and surveillance is maintained.

Adult↗
PubMed1987

Combined chemotherapy and irradiation therapy after radical surgery for leiomyosarcoma of the vulva. A case report.

Radical surgery failed to remove a leiomyosarcoma of the vulva completely, and residual tumour was left. Chemotherapy did not inhibit further local growth or the occurrence of secondary lesions in the lung. Irradiation therapy of the pelvis, including the area of the tumour, then successfully inhibited any further local growth, as evidenced by a marked decrease in size and eventual disappearance of the mass; however, the patient succumbed to distant metastasis.

Combined Modality Therapy↗
PubMed1986

Typhoid fever in pregnancy. Case report and review of the literature.

The clinical details of two cases of typhoid fever in pregnancy are described. The first patient contracted the disease in the third trimester, with successful outcome for both mother and baby. The second patient became infected in the first trimester, with the complication of underlying cardiac disease. This resulted in typhoid endocarditis contributing to fetal loss. A survey of the literature is presented and treatment recommendations outlined.

Abortion, Spontaneous↗
PubMed1984

Radiotherapy and surgery in the management of stage IB and IIA carcinoma of the cervix.

Ninety-two consecutive patients with stages IB and IIA carcinoma of the cervix were treated by one of two regimens: pre-operative intracavitary caesium-137 followed by a Wertheim hysterectomy (group 1) or staging laparotomy with biopsy of suspicious lymph nodes (group 2) (if there was no evidence of tumour on examination of a frozen section of the lymph nodes a Wertheim hysterectomy was performed, but if a tumour was present the abdomen was closed and a course of radical irradiation given). When there was evidence of extracervical spread on examination of the specimen after the Wertheim hysterectomy, postoperative irradiation was given. It was found that clinical staging had been incorrect in 38,5% of patients thought to have stage IB disease and in 71,4% of those thought to have stage IIA disease. The actuarial survival curves showed no significant statistical difference between group 1 and group 2. When examination of the operative specimen showed tumour invasion of the parametrium only, the disease was well controlled by postoperative irradiation (all 7 such patients survived). On the other hand, when there was evidence of tumour invasion of pelvic lymph nodes the 4-year survival rate fell to 31% (4 out of 13 patients), despite the use of postoperative irradiation.

Adult↗
PubMed1979

Chronic salpingo-oöphoritis with hydrosalpinx formation and ureteric obstruction: A case report.

An association between gynaecological lesions and dilatation of the upper urinary tract has frequently been described. Hydronephrosis as a result of pelvic inflammatory disease has, however, rarely been reported in the literature. The case presented here illustrates the importance of investigation by means of excretory urography in patients with pelvic inflammatory disease presenting with renal symptoms and signs.

Adult↗
PubMed1976

Turner's syndrome with XO/XXp- karyotype: a case report.

An unusual case of Turner's syndrome is presented. The case highlights the importance of chromosome analysis in patients presenting with primary amenorrhoea. This patient demonstrates the effects of mosaicism and the importance of the long and short arms of the X chromosome. Deletion of the short arm has only been reported in 2 previous cases of Turner's syndrome. The absence of the short arm is believed to be responsible for the shortness in stature in these patients.

Adult↗
PubMed1975

Granulomatous lesions of the cervix uteri in Black patients.

The incidence of tuberculous, bilharzial and amoebic cervicitis in Black patients at Baragwanath Hospital for the past 5 years is presented. The clinical presentation and the macroscopic and microscopic features of each type of cervicitis are discussed. The treatment of each condition is described, and the importance of differentiating cervical carcinoma from granulomatous cervicitis is stressed.

Black or African American↗