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Biomedical subjects

A B Levashov

Publications and source records attributed to A B Levashov.

4 recordsLinked to original sources
PubMed1991

[Alkaline phosphatase in reverse micelles of surfactants in organic solvent].

A dimeric enzyme (alkaline phosphatase from calf intestinal mucosa) was studied in the reversed micellar medium of Aerosol OT (AOT) in octane. The dependence of the enzyme's activity on the hydration degree (on the size of micelles) is a curve with two optima corresponding to the hydration degrees [H2O]/[AOT] = 17 and 25; when the inner cavity radii of reversed micelles are equal to the size of the enzyme's monomer (Mr = 70 000) and of the dimer (Mr = 140 000). Ultracentrifugation experiments showed that a reversible dissociation of the enzyme into subunits takes place as a result of the change of the hydration degree; the first and second maxima corresponding to the functioning of the monomeric and dimeric forms of the enzyme, respectively.

Alkaline Phosphatase↗
PubMed1991

[Biosorption with extracorporeal use of heterologous spleen in the complex treatment od suppurative-septic diseases].

The search for new methods in the control of purulent infection is highly topical nowadays. For this purpose a complex of intensive therapy is suggested involving hemosorption via the patient's blood perfusion through porcine heterospleen. By literature and experimental data this technique is not inferior in efficacy to the use of the donor spleen. The spleen is removed conventionally, in modification of the authors. The results of the hemosorption analysed on 82 procedures performed in 1989-1990 justify employment of the above hemosorption in view of its efficacy, availability, simplicity.

Adolescent↗
PubMed1990

[Extracorporeal connection of heterologous spleen (ECHS) in the combined intensive therapy of sepsis].

Biohemosorption by means of extracorporeal connection of heterogeneous spleen renders not only powerful detoxic action, but intensive immunomodulation action as well. Swine spleen used for biohemosorption possess high bacterisorptive and immunomodulating potential. The cases of persistent course of disease, development of antibacterial therapy, grave condition of a patient serve as an indication for application of extracoproreal connection of heterogeneous spleen within the complex of intensive therapy. During 1989 in the hospital were treated 9 patients with osteomyelitis and extensive suppurative foci of soft tissues of the locomotor apparatus, complicated by severe sepsis. Those patients were applied to totally II extracorporeal connections of heterogeneous spleen and 8 biohemosorptions by means of heterogeneous spleen sections. In general, intensive therapy with application of extracorporeal connection of heterogeneous spleen was effective enough. All patients with no exception left hospital in satisfactory condition in 28-56 days after the beginning of treatment.

Adult↗