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Biomedical subjects

A B MacLean

Publications and source records attributed to A B MacLean.

At least 55 records · Page 3Linked to original sources
PubMed1986

Colposcopic assessment of the lower genital tract in female renal transplant recipients.

The incidence of epithelial or cutaneous abnormality of the lower genital tract was studied colposcopically in 31 women aged 35 (SD9) years on renal replacement therapy for one to 184 months (mean 73 months). Twenty-four women had a renal transplant and had received immunosuppressive therapy for two to 173 months (mean 61 months). Seven women (two with failed transplants) were on home hemodialysis (one to 48 months, mean 19 months) awaiting transplantation. In 22 women (17 transplant and 5 dialysis patients) no abnormality was found. One hemodialysis patient had an extensive area of vulval intra-epithelial neoplasia. Five transplant recipients had evidence of genital papilloma virus (HPV) infection. No patient had cervical intra-epithelial neoplasia or invasive genital tract malignancy. The high incidence of HPV-associated lesions in this group, and the increasing evidence that HPV changes may predispose to cervical neoplasia suggest that this high risk group require regular gynecological assessment.

Adult↗
PubMed1985

Cytology, colposcopy and cervical neoplasia.

There have been suggestions that the failure to reduce the incidence of cervical carcinoma in New Zealand is due to a failure to take cervical smears from women at risk, and to appropriately manage those with abnormal smears. Review of data collected from a clinic in Christchurch over a four-year interval found that the majority of those with invasive cancer had never had a smear taken, or had not had smears taken frequently enough. There was evidence that cytology does not always correlate with definitive histology, and that patients with abnormal smears sometimes experienced lengthy delays before being referred for management. Comments are made on who should have smears, how often, and how women with abnormal smears should be managed.

Adolescent↗
PubMed1985

Pilot study of cervical cytology screening in a sexually transmitted diseases clinic.

A pilot study of cervical cytology was carried out on 500 new patients at the women's sexually transmitted disease (STD) clinic at this hospital. The aim was to discover the incidence of abnormal smears in order to gauge the worth of cervical cytology as a routine clinic procedure. Information was also gathered on each patient's age, sexual history, method of contraception used, previous smears, and genital infection. Smears showing carcinoma in situ, dysplasia, or warty atypia were regarded as abnormal, and the relevant patients were referred for colposcopy. Seventy-three (14.6%) had abnormal smears. Eight women (1.6%), average age 29.7 years, had cervical intraepithelial neoplasia grade III (CIN III) confirmed by histology. One third of the patients with abnormal smears had genital warts, and the incidence of abnormal smears was greater in patients with genital warts than in those without warts. We concluded that STD clinics are useful places in which to carry out cervical cytology screening, and we noted a positive association between infection with genital warts and abnormal smears.

Adult↗
PubMed1984

The presence of RNA complementary to HSV-2 (herpes simplex virus) DNA in cervical intraepithelial neoplasia after laser therapy.

In-situ hybridization of radiolabelled DNA probes to tissue sections detected RNA complementary to HSV-2 (herpes simplex virus) DNA in 65% (22 of 34) biopsies from cervical intraepithelial neoplasia (CIN) and in none of internally paired benign epithelia from individuals before treatment by laser vaporization cone. Laser therapy did not produce an increase in clinical or subclinical HSV infections of the cervix. Of 18 patients with RNA complementary to HSV-2 DNA in CIN biopsies before treatment, in whom treatment was successful, virus transcripts were detected at follow-up in only two of them.

Cervix Uteri↗
PubMed1984

Healing of cervical epithelium after laser treatment of cervical intraepithelial neoplasia.

The recognition that only a minority of cervical premalignant lesions progress to invasion, and the increasing incidence of these lesions in young women, has led to a more conservative approach in the treatment of cervical intraepithelial neoplasia. One such method uses the carbon dioxide laser but inadequate length of follow-up has prevented a prediction of risk of recurrence. Observations made in this study on the speed of healing, source of new epithelium, maturation of the epithelium and the absence of herpes nucleic acid suggest that this risk is low.

Cell Differentiation↗
PubMed1984

Cervical healing and Langerhans' cells.

A study of cervical epithelium healing after laser treatment found the early presence of Langerhans' cells. These cells were demonstrated using a histochemical technique for adenosine triphosphatase. The significance of Langerhans' cells in healing epithelium and their probable immunological role is discussed.

Cervix Uteri↗
PubMed1981

Home monitoring of blood glucose in diabetic pregnancy.

A study of home monitoring of blood glucose in diabetic pregnancy was made by a retrospective analysis of medical records of women who attended Christchurch Women's Hospital from 1976 to 1980. Of 20 previously-diagnosed insulin-dependent diabetics eight had used home blood glucose meters during pregnancy. The meter users spent on average 23.9 fewer days in hospital and attended on average 4.2 more antenatal clinics. Otherwise management and outcome were equivalent. We conclude that home monitoring of blood glucose is an effective and safe means of minimising hositalisation in diabetic pregnancy without compromising outcome.

Apgar Score↗
PubMed1981

Detection of RNA complementary to herpes simplex virus DNA in human cervical squamous cell neoplasms.

Nonneoplastic and neoplastic cervical biopsy specimens were examined by in situ hybridization to 125I-labeled DNA of herpes simplex virus (HSV), adenovirus, and bacteriophage lambda DNA's, and quantitative hybridization data were obtained using a Video Image Analyser. HSV-specific RNA was detected in 72% of cervical intraepithelial neoplasia, 60% of squamous cervical carcinomas, 2% of nonneoplastic cervices, and 9% of primary adenocarcinomas of the cervix. None of the tissues gave positive hybridization with adenovirus or lambda DNA probes. In paired biopsies of cervical intraepithelial neoplasia and nonneoplastic epithelium from 29 individuals, HSV-specific RNA was detected only in the epithelium of the neoplastic sample and not in the nonneoplastic control. Infectious HSV-2 was isolated from a low proportion (2%) of both ectocervical swabs and cell-free tissue extracts of patients examined, suggesting that the HSV-specific RNA detected in squamous cell neoplasms was not due to overt infections.

Antibodies, Viral↗