Biomedical subjects

A B Magil

Publications and source records attributed to A B Magil.

40 records · Page 3Linked to original sources

PubMed1981

Monocytes in human glomerulonephritis. An electron microscopic study.

Recent studies in experimental glomerulonephritis (GN) suggest that the monocyte is involved in the clearance of detritus and deposits from glomeruli. Whether this concept applies to human GN is unclear because of the paucity of studies in this area. Histochemical evaluation of more than 300 human renal biopsies disclosed eight cases of diffuse proliferative GN which demonstrated relatively large numbers of intraglomerular nonspecific esterase-positive cells. The diagnoses included GN associated with mixed essential cryoglobulinemia (three cases), diffuse lupus GN (three cases), and idiopathic diffuse proliferative GN (two cases). Electron microscopy disclosed extensive deposition of electron-dense material along glomerular basement membranes. Monocytes were present within capillary lumina, were usually associated with visible deposits, and often insinuated themselves between endothelium and the deposits so as to abut the deposits directly. The cells showed evidence of maturation (activation). The contents of the secondary lysosomes were generally similar in structure and density to neighboring deposits, especially in one case in which the deposits had an organized structure. The findings suggest that these monocytes are involved in the clearance of deposits from the glomerulus.

Basement Membrane↗

PubMed1980

Acute interstitial nephritis associated with thiazide diuretics. Clinical and pathologic observations in three cases.

Renal failure insidiously developed in three patients treated with a combination of hydrochlorothiazide and triamterene five to 10 weeks after commencing therapy. All had normal renal function prior to therapy and none had preexisting renal disease. Two of the patients had eosinophilia and two had a fever. One patient was oliguric. Renal biopsy demonstrated acute interstitial nephritis histologically. Direct immunofluorescence did not disclose evidence of either immune complex or antitubular basement membrane antibody deposition. Withdrawal of the drug led to remarkable improvement with renal function returning to normal in two patients and near normal in the third. The sequence of events and the histologic findings strongly suggest that the acute interstitial nephritis was due to a drug-induced hypersensitivity reaction. Although hydrochlorothiazide appears to be the drug responsible for the reaction, certain observations suggest a possible potentiating role for triamterene.

Aged↗

PubMed1980

Differences between the O-acetylated sialic acids of the epithelial mucins of human colonic tumors and normal controls: a correlative chemical and histochemical study.

Chemical analyses, together with histochemical assessments, were carried out on specimens of adenocarcinoma of the colon and histologically normal colonic epithelium (from resection margins from cases of carcinoma of the colon). In the epithelial glycoproteins of the normal tissue, both chemical and histochemical investigations indicated that the great majority of the sialic acids contained a side-chain O-acyl substituent located at position C8, whereas the side-chain substitution of the sialic acids of tumor glycoproteins was markedly reduced. Chemical analysis of the normal glycoproteins indicated that the great majority of the sialic acids were resistant to digestion with Vibrio cholerae neuraminidase, presumably due to an ester substituent at C4. The sialic acids of the tumor glycoproteins were significantly different from normal, in that they were less resistant to digestion with neuraminidase (p greater than 0.01), and therefore had a lower percentage of substitution at C4 (p greater than 0.01).

Adenocarcinoma↗

PubMed1979

Membranoproliferative glomerulonephritis type 1: comparison of natural history in children and adults.

Clinical, laboratory and pathological data on 46 patients (29 children and 17 adult) with Type 1 membranoproliferative glomerulonephritis (MPGN) were reviewed in order to compare the natural history of the disease in two age groups. The nephrotic syndrome was the most common presenting clinical feature in both age groups. Established renal failure at time of biopsy was seen in adult males only. All the adults males, but none of the women, were either dead or in renal failure after a mean duration of diseases of 17.7 months. In contrast 43% of the children (both sexes) were in renal failure after a mean duration of disease of 51.6 months. Statistical analysis disclosed that only up to 48 months was there a significant difference in survival between the two age groups (P less than .01). Beyond this time the difference was not statistically significant. The difference in behaviour of MPGN in the two age groups is similar to that observed in other glomerulonephropathies.

Adolescent↗