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Biomedical subjects

A B Oyediran

Publications and source records attributed to A B Oyediran.

At least 19 recordsLinked to original sources
PubMed1993

Severe morbidity among children in a trial malaria chemoprophylaxis with pyrimethamine or chloroquine in Ibarapa, Nigeria.

In a controlled trial of weekly malaria chemoprophylaxis with chloroquine and pyrimethamine there were no significant differences in type and frequency of severe morbidity during chemoprophylaxis. Administration of chemoprophylaxis during the current and immediately preceding month was associated with significantly fewer episodes of severe morbidity in the chloroquine and pyrimethamine groups when each was compared with the control multivite group. After chemoprophylaxis had been stopped, significantly more episodes of severe morbidity occurred in the chloroquine group than the control group, but a similar trend in the pyrimethamine group was not statistically significant. In the control group most of the episodes of severe morbidity, including those episodes which were associated with heavy parasitaemia, occurred below the age of 4 years. In contrast, the children who received chemoprophylaxis continued to experience such illness at older ages. The difference between the chloroquine group and the control group in respect of age at time of severe morbidity was statistically significant.

Age Factors↗
PubMed1992

A prospective study on some factors which influence the delivery of low birth weight babies in a developing country.

The study was prospective in design and carried out in Ibadan, Nigeria. It was undertaken in order to provide more information on the low birth weight deliveries seen here and to evaluate some factors associated with their births. 600 randomly selected gravid women who presented to the antenatal booking clinics for the first time in this pregnancy were followed up till delivery of their babies. Data on 492 women who produced normal, singleton babies were analysed. The mean birth weight was 3167g +/- 451g (males; 3205g +/- 469g and significantly higher than of females of 2991g +/- 468g). The incidence of low birth weight (LBW) weight of 2500g and less was 8.3% and comprised of 18 males, 22 females and 1 unknown sex. 80% of these LBW babies were term (37-41 wks gestation) at delivery, while 20% were pre-term (< 37 wks). There was seasonal variation in the incidence of LBW, the risk being highest during the peak of dry season and lowest during the rainy season. The mothers age, parity, height, ponderal index at delivery, and total maternal weight gain as well as birth interval were each significantly related to the incidence of LBW in these mothers (P < 0.01). Maternal education as well as socio-economic class were not significant (P > 0.5).

Adolescent↗
PubMed1992

Cross-cultural studies in Alzheimer's disease.

The search for risk factors for Alzheimer's disease would be greatly enhanced by identification of populations with significantly different prevalence rates, particularly if these populations consisted of ethnic groups now living in different environments and cultures. Evidence is presented that two such groups are worthy of further study: subjects of African origin living in Africa and in the West and Native Americans living on and off reserves.

Black or African American↗
PubMed1991

Epidemiology of age-related dementias in the Third World and aetiological clues of Alzheimer's disease.

The prevalence of age-associated dementia which already constitutes enormous public health problems in many developed industrialised countries, is currently low in many developing countries. Community-based studies and autopsy survey in Nigerian Africans showed absence of Alzheimer's disease (AD). The ageing revolution with enormous increase in the population of the elderly is already occurring in developing countries which are also undergoing epidemiological transition. Geographical epidemiological studies of the age associated dementias, in developing and developed countries, and especially in ethnic groups who live in different environments have great potential in identifying putative risk factors, probably currently present in developed industrialised countries and absent in developing less industrialised countries where the disease is as of now relatively uncommon.

Age Factors↗
PubMed1984

Contact tracing in the control of STD in Ibadan, Nigeria.

Contact tracing carried out at this clinic was analysed as part of measures for control of sexually transmitted disease (STD). Results showed that 50% of 156 contacts could not be traced at all for various reasons, and that 47% of the contacts were brought in through persuasion by index patients who had been counselled at the clinic. Only four contacts were traced, and two of these attended the clinic. Index patient cooperation is thus identified as the most important factor in the success of contact tracing, because of the high level of illiteracy and poor communications facilities in Nigeria, compared with industrialised countries.

Adolescent↗
PubMed1982

Serum creatinine and prediction formulae for creatinine clearance.

Three formulae which could predict creatinine clearance from serum creatinine values were derived from the data which were obtained from the study of 169 patients and healthy control subjects. Values for creatinine clearance which were obtained by using these three formulae and four other previous formulae were compared with the observed values. Most of the predicted and observed values differed by more than 20% of the observed values. When a formula which was derived by using the data from forty-five healthy control subjects was used to predict the creatinine clearance values of this group and the patients, there was a close agreement between the observed and the predicted values for only the healthy control subjects but not the patients. Because of the various factors which affect creatinine excretion in health and disease, a predictive formula which includes serum creatinine alone and not urinary creatinine might give unreliable values.

Adult↗
PubMed1981

Clinical experience with praziquantel in the treatment of Nigerian patients infected with S. haematobium.

A double-blind controlled trial of 2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a] isoquinolin-4-one (praziquantel, EMBAY 8440, Biltricide) in the treatment of vesical schistosomiasis has been carried out in 90 Nigerian schoolchildren of both sexes aged 9--16 years. Oral doses of 1 x 30, 1 x 40, and 2 x 20 mg/kg b.w. were assessed against placebo at 1 x 40 mg/kg, and the subjects followed up for up to twelve months after treatment. The results showed that the drug is very effective against S. haematobium infections and well tolerated. There were not significant differences between the three dosage groups, and the drug had no adverse haematological or biochemical effects. It is concluded that praziquantel widely meets the requirements necessary for use in large scale control of vesical schistosomiasis.

Child↗
PubMed1979

Renal disease due to schistosomiasis of the lower urinary tract.

The literature concerning renal impairment and damage due to vesical schistosomiasis has been reviewed, with emphasis on radiologic, biochemical, and renographic studies of renal function in affected persons. Presently available evidence suggests that infections due to S. haematobium constitute an important public health problem because they are widely prevalent. A high proportion of affected persons suffer renal impairment and damage due to obstructive uropathic lesions in the lower urinary tract and, probably, through direct immunologic involvement of the kidney. It is therefore important that efforts should be intensified to better define the size and scope of the problem, and to control the disease.

Adolescent↗
PubMed1979

The effect of seasonal changes and socio-economic status on urinary pH and specific gravity.

Specific gravity and pH of urine in the dry and the wet season in three socio-economic Nigerian groups have been studied. Samples were collected at 7 a.m., 11 a.m. and 3 p.m. High-income subjects had a significantly lower urinary pH than low-income. During the wet season pH values were lower than in the dry, but not significantly so. During the day S.G. values did not differ, neither did they in different seasons. But there were significant differences between high and low income groups. S.G. and pH samples of high and low income groups were similar in children and in their parents. In medical students S.G. and pH in 24-hour urines were similar to the morning value of high and middle income groups and were not affected by season, but the volume was. The relevance of these findings is discussed relative to the rarity of urinary calculi in Nigerians.

Adult↗
PubMed1978

The importance of the urine flow rate in semi-quantitative assessment of the standard renogram.

Renograms were recorded at different rate of urine flow in 30 healthy Nigerian children to establish semi-quantitative criteria to assess the standard renogram. The results indicate that knowledge of the urine flow rate during renography is necessary for meaningful interpretation of the study. They further showed that for semi-quantitative assessment of the renogram the time to peak and time to peak half values are easily identified indexes that can be measured accurately with negligible observer variation. Regression equations for the relationship between urine flow rate on the one hand, and time to peak and time to peak half values on the other have been obtained and used to compute nomograms, which should be useful for future work in this area.

Adolescent↗
PubMed1978

Effects of haemoglobin electrophoretic pattern and seasonal changes on urine concentration in young adult Nigerian males.

Renal concentrating capacity has been measured in healthy young adult Nigerian males with normal (AA) and abnormal (AS) haemoglobin types in both the dry and the wet seasons after 13 to 15 hours hydropenia respectively. The results show that, in the dry season, urine osmolality values in AA subjects are similar to those observed in Caucasians. They further confirm that renal concentrating capacity is impaired in persons with the S gene, and emphasize the limitations of the specific gravity test as a measure of renal concentrating capacity. In healthy AA subjects, the urine osmolality during the wet season is significantly less than in the dry season, even after longer periods of hydropenia. AS subjects, on the other hand, exhibit no seasonal variation in renal concentrating capacity.

Adult↗
PubMed1977

Guinea worm inguinal adenopathy.

Genital involvement of Dracunculus medinensis is uncommon, and when it does occur, it usually involves the scrotum. A case has been described in which the inguinal gland was involved producing a bubo simulating that caused by other commoner conditions. It is suggested that the microscopical examination of a wet preparation of bubo aspirates should routinely be practised, especially in tropical countries.

Adult↗
PubMed1975

Infection of the mastoid bone with a Paragonimus-like trematode.

Three unusual cases of mastoid abscess are described. Case histories and the clinical, laboratory, radiological, surgical, and histopathological findings in the patients are reported. Operculated eggs measuring about 60 mu times 40 mu were seen in pus obtained from two cases, but no adult worm was recovered. The findings suggest that the infections could have been caused by either Paragonimus species or Poikilorchis (Achillurbania) species.

Adolescent↗
PubMed1975

Renographic studies in vesical schistosomiasis in children.

Renal function in children infected with Schistosoma haematobium and in uninfected controls has been studied with the I131 hippuran renogram. The results suggest that renographic abnormalities which persist after a water-load are more common in infected children who have heavy egg-output in their urine, and abnormal pyelograms. Specific chemotherapy restored the renogram to normal within 3 weeks in several cases. It is suggested that the renogram is useful for the assessment and followup of patients with vesical schistosomiasis, and further work should be done to more clearly define the renal function of such patients.

Adolescent↗