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Biomedical subjects

A B PARDEE

Publications and source records attributed to A B PARDEE.

At least 55 records · Page 3Linked to original sources
PubMed1952

The intracellular distribution of Lansing poliomyelitis virus in the central nervous system of infected cotton rats.

A procedure has been described for the centrifugal fractionation of the cellular particulate components of CNS tissue infected with poliomyelitis virus. A study of the distribution of infectivity among these components revealed that approximately four-fifths of the virus is found free in the submicroscopic particle fraction. The validity of the conclusion that the virus is located in this fraction of the intact neuron is discussed.

Animals↗
PubMed1951

Enzyme activity and bacteriophage infection. I. Breakdown of adenosinetriphosphate.

Experiments have been performed on the apyrase activity of E. coli, strain B. Although the dependence on pH and substrate is similar to that of rat tissue, the bacterial extracts are inhibited by Ca(++) and stimulated by Mg(++). In bacterial extracts the rate of phosphate release decreases in the course of the reaction, possibly owing to product inhibition. With multiple bacteriophage infection, the apyrase activity of the intact cells increased several fold, and the activity of extracts increased about 30 per cent. It is suggested that the changes could be attributed to an increase in the amount of enzyme although other alternatives cannot be precluded at present.

Adenosine Triphosphate↗