PubMed Health⌕ Search

Biomedical subjects

A B Petro

Publications and source records attributed to A B Petro.

7 recordsLinked to original sources
PubMed1991

A practical approach to laparoscopic cholecystectomy.

A prospective study of 500 consecutive cholecystectomies was initiated with the introduction of laparoscopic cholecystectomy. Laparoscopic cholecystectomy was attempted in 96% of patients presenting with primary gallbladder disease and was completed in 95%. There were no deaths or bile duct injuries. Two patients undergoing laparoscopic cholecystectomy were transfused for postoperative bleeding, and only one patient required reoperation for any reason. A prospective study showed reduced operating time (20 minutes) and patient charges ($546) using electrosurgical dissection compared with laser. Reusable trocars were used without any associated injury or morbidity. An effective strategy for selective cholangiography was developed based on patient history, liver enzymes, and common duct diameter. In conclusion, laparoscopic cholecystectomy appears to be a safe operation. The cost-effectiveness of laparoscopic cholecystectomy can be enhanced ($1,271) with no loss of patient benefit using the combination of electrosurgery, reusable trocars, and selective cholangiograms in low-risk patients.

Adolescent↗
PubMed1986

Sister chromatid exchange analysis in cultured primary lung, liver, and kidney cells of mice following in vivo exposure to vinyl carbamate.

Methods are described for the short-term culture (48 to 56 h) of lung, liver, and kidney cells from C57B1/6 mice. With these techniques, mice can be exposed in vivo to test compounds and the cells grown on cover glasses in the presence of 5-bromo-2'-deoxyuridine (BrdUrd) (5 microM) for analysis of sister chromatid exchange (SCE) and cell cycle kinetics. Mice exposed to vinyl carbamate (VC) ((10 to 60 mg/kg) by i.p. injection were used in the initial examination of this system. Cultured lung and kidney cells from exposed animals (60 mg/kg) exhibited significant increases in SCE frequencies (approximately 3 to 5 times baseline); however, liver cells were much less responsive and showed less than a twofold increase over baseline SCE levels. Lung cultures initiated as long as 320 h after VC exposure (60 mg/kg) revealed a persistence of lesions leading to the formation of SCEs in vitro. This methodology permits analysis of cytogenetic damage in organs with very low mitotic activity after in vivo exposure to known or suspected genotoxicants.

Animals↗
PubMed1976

A current appraisal of problems with gangrenous bowel.

Gangrenous bowel most often results from hernia, adhesions and mesenteric insufficiency. The overall mortality rate for 151 cases was 37%. This figure was 20% for hernia, 23% for adhesions and 74% for mesenteric insufficiency. In the latter category where bowel resection was feasable the mortality rate was 40%. Other causes of bowel gangrene had a mortality rate of 28%. In many instances the pathophysiologic processes were of such a nature that current medical expertise has not reached a level of development to effectively cope with the situation. There were, however, a significant number of cases where survival may have been achieved had it not been for deficiences on the part of the patient, the primary health care personnel or those in attendence at the referral center. The basic keystone for a successful outcome in the management of patients with the gangrenous bowel problem is early surgical intervention. All will be lost if patient exposure to this source of lethal toxins is allowed to proceed to an irreversible stage. Liberal antibiotic administration probably postpones the arrival of intractable hypotension. Other factors which can be expected to improve the survival rate include minimization of technical errors, repair of incidental hernias, elemination of dependence upon nasogastric tubes for the definitive management of patients with complete bowel obstruction (with one or two exceptions), and a firm commitment to the diligent pursuit and early definitive management of postoperative complications.

Anti-Bacterial Agents↗
PubMed1975

The association of parathyroid adenoma and non-medullary carcinoma of the thyroid.

Thyroid carcinoma was discovered in five of 56 (8.9%) patients operated upon for hyperparathyroidism. In only one instance was a mass palpated preoperatively. An additional 26% of the 56 patients had either multinodular goiter or follicular adenomas. It is thus important to biopsy the thyroid nodules which may represent malignancy.

Adenocarcinoma↗