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Biomedical subjects

A B Poletaev

Publications and source records attributed to A B Poletaev.

10 recordsLinked to original sources
PubMed1992

[Serum antibodies to brain protein antigens in cerebral palsy in children].

Using special brain antigen test-system ELITEST-24, ELISA assays of the serum of children with cerebral palsy were conducted. The data obtained were compared to relevant characteristics of the sera from neurologically and somatically healthy persons and patients with diagnoses of multiple sclerosis, schizophrenia, epilepsy and hepato-cerebral dystrophy according to special PC program VIZUAL and DIAGNOST. High specificity of the cerebral palsy anti-brain antigens reactivity was revealed by ELITEST technique. Moreover, the comparison of the mother-child pair immunoreactivity has been conducted. Evidence for hypothesis of epigenetically performing of children antibodies repertoires by mother-during-pregnancy immune status were obtained. Possible immunopathologic mechanisms of the disease are discussed.

Adult↗
PubMed1989

[Effects of beta endorphin and delta-sleep inducing peptide on resistance to emotional stress].

Enzyme immunoassay was used to study the contents of beta-endorphin and delta-sleep inducing peptide (DSIP) in blood and hypothalamus in rats of Wistar and August lines under acute emotional stress. The stress-resistance of the animals was determined by using preliminary behavior tests. The rats were divided into two groups and predisposed to acute emotional stress. It was found that the contents of these peptides in Wistar-rats, which are more resistant to emotional stress, were higher compared with the August-rats, which are more predisposed to emotional stress. It was shown that the contents of beta-endorphin and DSIP in Wistar-rats is higher than in predisposed Wistar-rats.

Acute Disease↗
PubMed1986

[Brain-specific proteins S 100 and reception of neuromediators by membrane preparations from the rat brain].

Study on specific binding of ligands of various nervous cell membrane neuromediator receptors revealed that brain-specific proteins S100 modulated in a dose-dependent fashion the level of specific binding. Proteins S100 (but not BSA or blood gamma-globulins) changed the Kd values of the ligand-receptor complexes and the number of binding sites. The effects of proteins S100 were specifically blocked by antibodies to S100. Proteins S100 influenced the functions of acetylcholine, serotonin, dopamine, noradrenaline and GABA receptors but not of opiate, imipramine, histamine and benzodiazepine receptors.

Animals↗
PubMed1977

[Immunochemical analysis of glial and neuronal fractions of rat brain].

A method of obtaining antineuronal and antiglial immune sera is described. Data of the quantitative immunochemical analysis of the antigens of the neuronal and glial fractions of the rat brain are presented. The neurons proved to contain 4, and the glia--3 brain-specific proteins; one or two of them are common for these cell fractions.

Animals↗