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Biomedical subjects

A B Robinson

Publications and source records attributed to A B Robinson.

At least 19 recordsLinked to original sources
PubMed1995

Haematology and blood biochemistry during the course of psoroptic scabies in sheep.

Haematology and blood biochemistry were monitored during the development and regression of psoroptic scabies in sheep. There were rises in numbers of neutrophils and eosinophils and in the fibrinogen concentrations, with lowered haemoglobin concentrations any lymphocyte numbers. The only biochemical parameters that were affected were the estimated serum globulin concentration, which rose during the disease process, and the serum albumin concentration, which fell. All of these changes reverted to normal soon after treatment.

Animals↗
PubMed1994

Suppression of squamous cell carcinoma in hairless mice by dietary nutrient variation.

In experiments involving the induction of squamous cell carcinoma in 1846 hairless mice that were maintained on a wide variety of diets, it was found that those diets with the least optimum balance of nutrients had the greatest inhibitory effect on growth of cancer. Rate of onset and severity of tumors was caused to vary over a 20-fold range by means of dietary balance alone. These experiments suggest that dietary variation in general and intentional malnutrition in particular should be given special attention in the control of existing cancer in humans.

Animal Feed↗
PubMed1991

Distribution of glutamine and asparagine residues and their near neighbors in peptides and proteins.

In a statistical study of neighboring residues in 1465 peptides and proteins comprising 450,431 residues, it was found that the preferences for residues neighboring to glutamine and asparagine residues are consistent with the hypothesis that the rates of deamidation of these residues are of biological significance. Some dipeptide and tripeptide structures have special usefulness and some are especially undesirable. More such structures exist for amide residues than for other residues, and their specific types are those most relevant to the deamidation of amide residues under biological conditions.

Amino Acid Sequence↗
PubMed1991

Quantitative measurement of human physiological age by profiling of body fluids and pattern recognition.

Quantitative correlations with human age are demonstrated for 60 substances from a group of 200 substances measured in the urine of 235 men. Simplified pattern recognition calculations are used to combine these correlations into patterns of human age and to demonstrate their utility for the quantitative measurement of human physiological age and aging rate. The empirical use of these techniques for the extension of human life-span and diminution of human suffering from degenerative diseases is discussed. Current experimental limitations of this method are demonstrated and evaluated. The application of these techniques can form the basis for a significant advance in the quality of human life.

Adult↗
PubMed1979

Molecular clocks, molecular profiles, and optimum diets: three approaches to the problem of aging.

It has been hypothesized that the deamidation of glutaminyl and asparaginyl residues serves as a molecular clock for many biological processes including protein turnover, development, and aging. At present, this hypothesis has passed some experimental tests which are necessary but not sufficient for its acceptance. The current state of evidence about deamidation as a molecular clock is discussed. In addition, since the molecular biology of aging, especially in humans, is only partly understood, it is of value to develop quantitative, empirical measures of physiological human age and to use these measures to evaluate alternative human living conditions, especially easily adopted alternatives like variations in diet. This may allow some decrease in the suffering and loss from human aging until such time as molecular biology provides superior and more intellectually satisfying answers. An empirical system which consists of quantitative measurement of several hundred human chemical constituents followed by computerized pattern recognition is described. It is hoped that this system will eventually become an aid in the minimization of the rate of human aging through changes in diet and other factors.

Adult↗
PubMed1975

Urine vapor pattern for olivopontocerebellar degeneration.

Autosomal dominant olivopontocerebellar degeneration was evaluated in a family numbering 414 living members. Urine samples were obtained from 5 affected and 5 unaffected not at-risk family members after 4 days on a synthetic diet. 159 urine vapor constituents were measured by gas-liquid and ion-exchange chromatography and a non-correlation index was calculated. 2 distinct populations of urine vapor patterns were identified which conformed to the normal and disease affected groups, thus a diagnostically useful pattern for this disease in this family has been demonstrated which will be helpful in genetic counselling and potential elimination of the disease.

Adult↗
PubMed1975

Sex-related patterns in the profiles of human urinary amino acids.

The urinary amino acid profiles of 79 young women and 72 young men were studied with an automated highpressure amino acid analyzer. A nonparametric statistical analysis was applied for detecting profile differences related to sex and other variables. A strong sex-related pattern was confirmed and its power for sex determination was evaluated. For the women, profile differences related to the use of oral contraceptives were also discovered and evaluated. No correlation with the menstrual cycle was detected.

Adolescent↗
PubMed1974

Primary sequence dependence of the deamidation of rabbit muscle aldolase.

The first-order deamidation half-time of the peptide, Gly-Ser-Asn-His-Gly in phosphate butler, pH 7.4, ionic strength at 0.2, 37.0 degrees C, is 6.4 +/- 0.5 days. This compares favorably with the in vivo deamidation half-time of 8 days for this sequence in rabbit muscle aldolase. This fact is discussed with respect to the general hypothesis that sequence-controlled deamidation of glutaminyl and asparaginylresidues is a mechanism by which molecular and organismic development and aging are timed.

Amides↗