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A B Rothballer

Publications and source records attributed to A B Rothballer.

18 recordsLinked to original sources
PubMed1975

Natriuresis following fourth ventricle perfusion with high-sodium artificial CSF.

Perfusion of the fourth cerebral ventricle with high-sodium artificial cerebrospinal fluid was found to result in an increase in urinary sodium excretion in anesthetized cats. The natriuresis was accompanied by an increase in blood pressure and glomerular filtration rate. However, in animals with the changes in blood pressure and glomerular filtration rate prevented by alpha adrenergic blockade (phenoxybenzamine), the increase in urinary sodium excretion persisted. the data suggest the presence of a neural mechanism in the vicinity of the fourth ventricle sensitive to cerebrospinal fluid sodium levels and capable of affecting urinary sodium excretion independent of changes in blood pressure or glomerular filtration rate. The possible role of the area postrema and adjacent medulla is considered.

Adrenergic alpha-Antagonists↗
PubMed1975

Neurohypophysial electrical activity in the anesthetized cat.

The spontaneous electrical activity of the neural lobe of the cat hypophysis has been recorded. We have observed two types of activity: (1) 0.5-1.0 mV in amplitude and 4-6 msec in duration, and (2) 0.03-0.07 mV in amplitude and 1-2 msec in duration. The discharge rates of both types of activity are affected by osmotic stimuli known to influence vasopressin release. Nevertheless, only the smaller potentials were studied because they were easier to obtain. The typical response to injections of hypertonic saline was an increase in the discharge rate characterized by two peaks in the frequency-time curve. This activity seems to correspond to the unit activity described by several authors for neurosecretory hypothalamic units. Hypotonic injections cause, in about 45% of the injections, a 50% decrease in the firing rate. Injections of isotonic saline did not alter the discharge rate by the neurohypophysis. We conclude that elements in the neural lobe of the pituitary are electrically excitable and respond to stimuli known to cause vasopressin release.

Animals↗