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Biomedical subjects

A B Samal'

Publications and source records attributed to A B Samal'.

16 recordsLinked to original sources
PubMed1991

[Chlorine e6-sensitized photoinhibition of thrombocyte aggregation. Participation of active oxygen forms].

It has been shown that photosensitized action of chlorin e6 (Che6) on platelet-rich plasma leads to platelet aggregation inhibition. Che6-sensitized photoinactivation of platelets was intensified in the presence of singlet oxygen interceptor. The aggregation rate of light-irradiated platelets in the presence of Che6 in D2O buffer was higher than in H2O buffer. The participation of active oxygen forms in the determination of platelet function has been considered.

Chlorophyllides↗
PubMed1989

[The pH of the culture medium as a factor regulating the functional properties of thrombocytes].

Thrombin-induced time-dependent alteration of light-transmission was studied in platelet suspensions with varying pH in calcium-free media, and in the presence of calcium ions. It has been shown that thrombin-induced platelet aggregation and preaggregation stage character are determined by the pH-dependent structural and functional state of the platelet membrane systems.

Adenosine Diphosphate↗
PubMed1984

[Chemiluminescence of thrombocytes in thrombin-induced aggregation].

Chemoluminescence induced by thrombin and aggregation of thrombocytes as well as effect of aspirin on the reactions were studied. Intensity of thrombin-induced chemoluminescence correlated with accumulation of malonic dialdehyde and hydroperoxides in cells. Chemoluminescence of thrombocytes appears to occur after the thrombin stimulation of cyclooxygenase pathway of arachidonic acid oxidation in cells.

Arachidonic Acid↗
PubMed1983

[pH-dependent conformational changes in thrombocyte proteins].

A study was made of the medium pH influence on structural states of platelets by optical methods. Within the pH range (6-8), two pH induced reversible changes of platelet state were observed. A conclusion is made that the structural rearrangements in platelets induced in the medium by changes in hydrogen ion concentration may involve some rearrangements in platelet proteins, and thus acting as a factor regulating platelet function.

Blood Platelets↗
PubMedDate not supplied

[The chlorine e6-photosensitized inhibition of human thrombocyte aggregation].

ADP-induced aggregation of platelets in the presence of chlorin E6 under the action of visible light depending on the pigment concentration and the time of light action was studied. It was shown that the photosensitized effect of chlorin E6 on the platelet-enriched plasma results in platelet aggregation inhibition.

Adenosine Diphosphate↗
PubMedDate not supplied

[Structural-functional state of platelets at the initial stage of aggregation].

ADP-induced changes of light transmission of platelet suspension were studied with a laser aggregometer at concentration variation of both cells and aggregation agents. It was shown that a decrease of light transmission of platelet suspension was due to structure-morphological changes of platelets and pseudopodia formation. An investigation method of platelet aggregation with a small content of cells in the solution permits to fix distinctly the stages of the platelet structural states in the processes of stimulation and aggregation.

Adenosine Diphosphate↗
PubMedDate not supplied

[Lipid peroxidation and development of dystrophic changes in the intervertebral disks during atherosclerosis].

Lipoproteins of intervertebral discs, spinal cord and blood were studied spectrofluorimetrically in experimental atherosclerosis. Lipoproteins and hydroperoxides accumulated in the intervertebral discs under dystrophic conditions. Blood serum lipoproteins were involved in pathogenesis of these atheromatous impairments in the intervertebral discs. Content of lipoproteins in the discs might be normalized by means of diet-fasting therapy.

Animals↗
PubMedDate not supplied

[Induction of human platelet aggregation by nerve tissue antigens and immune complexes].

It is shown that antigens of the peripheral nerve and immune complexes (IC) are able to induce platelet aggregation. The highest IC aggregation activity was seen in the excess of the antigens. Specific antiserum had no aggregation capacity, but IC produced in its participation displayed higher aggregation activity than free antigens. The involvement of antigens and IC of the peripheral nerve in impairment of platelet function is suggested.

Antigen-Antibody Complex↗
PubMedDate not supplied

[The anticoagulant action of the nitric acid ester of oxidized starch].

The effect of oxidized starch (OS) which contained 15% of COOH groups and its nitroether (NOS) with 4% of nitrogen on coagulation properties of rat blood was studied in vitro and in vivo. The results of the study in vitro showed that OS did not affect the function of the coagulation system. In contrast to OS, a dose-dependent increase in prothrombin-, thrombin time, and activated partial thromboplastin time was observed for NOS. The activity of the components of the internal coagulation pathway changed when the NOS concentration reached 0.1 mg/ml. At a concentration of 0.6 mg/ml and higher this compound affect the external pathway and final stage of coagulation. According to the efficiency (in vitro) of the influence on the thrombine time I mg/ml NOS corresponded to 0.2 U/ml of heparine. The anticoagulant effect of NOS was also observed in vivo along with reliable changes in thromboplastin and thrombin time. Antithrombin activity of plasma remained the same. Standard test was negative and indicated to the absence of fibrin monomers. The pronounced anticoagulant effect of NOS in the experiments in vitro and quick response in the experiments in vivo make it possible to consider this compound as anticoagulant of direct action.

Animals↗