Biomedical subjects

A B Schmidt

Publications and source records attributed to A B Schmidt.

5 recordsLinked to original sources

PubMed2001

Brazilian population database for the 13 STR loci of the AmpFlSTR Profiler Plus and Cofiler multiplex kits.

Allele frequencies for the 13 STR core loci (D3S1358, VWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, D7S820, CSF1PO, TPOX, THO1 and D16S539) included in the AmpFlSTR((R)) Profiler Plus and AmpFlSTR((R)) Cofiler kits were obtained for a sample of 700-800 genetically unrelated Brazilians. The expected performance of these loci for personal identification and paternity testing in the Brazilian population was estimated.

Alleles↗

PubMed2001

The magnitude of osteoporosis in middle aged women.

OBJECTIVE: This study aims to increase the body of knowledge regarding osteoporosis in the Jordanian context by investigating the magnitude of osteoporosis amongst perimenopausal women, as well as the risk factors associated with the disease. METHODS: Two hundred and fifty one women between the ages of 40 to 60 years were randomly selected from the Orthopedics and Rheumatology out patient clinics at the Major Teaching Hospital in Amman, Jordan. A structured questionnaire, which focused upon risk factors and preventive measures for osteoporosis, was administered by a trained staff nurse to all women. Index women were then referred to a private hospital, also in Amman, for a dual energy x-ray absorptiometry of the lumbar spine (Lumbar 1-4) and hip. RESULTS: Results show the magnitude of osteoporosis was 13% according to the bone mineral density of the lumbar spine. Women with osteoporosis were older (p< 0.00) and smaller in build (p<0.00) than women with low or normal bone density. Osteoporotic women were also more likely to be menopausal (p<0.00) and to have taken corticosteroids for a prolonged period of time (p<0.00). Logistic regression showed being menopausal (p<0.00), taking corticosteroids (p<0.05), and having a relatively lower body mass index (p<0.00) were significantly related to being osteoporotic in this group of women. CONCLUSION: The authors conclude that this study was not only able to report upon the magnitude of osteoporosis among women sampled, and the risk factors for low bone density, but also raised issues related to inconsistencies in how the health care system deals with women who are at risk for osteoporosis. Study findings are discussed in their socio-cultural context, and implications of the study findings are presented.

Adult↗

PubMed1997

Applications of the pedicled vastus lateralis flap for patients with complicated pressure sores.

The vastus lateralis muscle- or musculocutaneous flap is a well established tool in the surgery of pressure sores of the pelvic region. Its size, its constant large axial vascular pedicle originating from the lateral circumflex femoral artery, and its ability to carry quite a large skin island from the distal lateral region of the upper thigh makes this flap a very versatile one in the management of difficult situations. The vastus lateralis flap allows the simultaneous closure of defects in the trochanteric and sacral region, a technique which has not been described previously. A pedicled vastus lateralis flap may be the only remaining local salvage procedure for defects due to obstruction of internal and external iliac arteries and aortobifemoral bypass surgery. This is another application which has not yet been described in the medical literature. The outcome of a series of 38 vastus lateralis flaps and the complications are shown. The follow-up period ranged from 3 months to 4 years. One flap was lost. More complications were seen at the donor site than at the reconstructed defect. In patients who may be able to walk or stand at a later date, potential impairment of these functions has to be considered. In our opinion, the vastus lateralis flap is an excellent tool for managing large tissue defects in difficult situations.

Adolescent↗

PubMed1996

Size effects in nonpolar solvation: lessons from two simple models.

Size dependence of the solute chemical potential mu(u) is examined using the Ornstein-Zernike equation for two models of the nonpolar solute-solvent interactions. Simple Lennard-Jones interactions are assumed in the first model while the Lennard-Jones potential is distributed over the solute volume in the second model similar to the Hamaker theory for the colloid dispersion forces. In both models, while mu(u) rises asymptotically as the third power of the solute size in agreement with asymptotic solution of the scaled particle theory, it increases faster at smaller sizes. Deviations from the cubic law are more pronounced at higher solvent densities and stronger molecular interactions. Within a relatively narrow size range typical for small organic molecules, mu(u) can be approximated with a polynomial of the third or even the second power. However, the latter approximation is less accurate and cannot be employed for extrapolation to the larger size region.

Journal Article↗

PubMed1995

Applicability of a continuum solvation model to the octanol water transfer: CFF91 based model for amino acids.

A continuum hydration model based upon the atomic charges provided with the CFF91 force field [A. B. Schmidt and R. M. Fine (1994) Molecular Simulation, 13, 347-365] has been extended to the octanol-water transfer. The electrostatic component of the transfer free energy is calculated using the finite-difference solution to the Poisson-Boltzmann equation while the nonpolar contributions are assumed to be proportional to the solute-excluded volume in water. All atomic charges and radii besides the aromatic carbon radius are equal in both solvents. The octanol dielectric constant and the probe radius are the main fitting parameters defining the octanol phase. The model has been tested for 38 organic molecules related to the amino acid residues and generally provides a high accuracy. In particular, the mean unsigned error for N-acetyl amino acid amides is 0.5 kcal/mol.

1-Octanol↗