PubMed Health⌕ Search

Biomedical subjects

A B Shekhter

Publications and source records attributed to A B Shekhter.

123 records · Page 7Linked to original sources
PubMedDate not supplied

[The effect of phosphatidylcholine on repair processes in liver cells in acute CCl4 damage].

Effect of phosphatidylcholine, isolated from soy beans and sunflower seeds for laboratory use, on synthesis of RNA, DNA, albumin and content of newly synthesized mRNA in polyribosomes was studied in hepatocytes after chemical hepatectomy produced by single administration of CCl4 into rats; histological and histochemical studies of liver tissue were also carried out. Phosphatidylcholine from these plants was found to prevent hepatocyte dystrophy and necrosis development, to activate the macrophage response and to stimulate reparation inducing synthesis and secretion of the tumor necrosis factor. The rate of highly labelled RNA synthesis, mainly mRNA, decreased in liver tissue of rats treated with CCl4, was increased approximately 2-fold after the phospholipid administration. The phospholipid from soy beans restored the albumin synthesis as well as the content of newly synthesized mRNA in rat polyribosomes, while phosphatidylcholine from sunflower seeds restored effectively the mitochondrial DNA synthesis. Promising application of these phosphatidylcholines as hepatoprotectors is discussed.

Albumins↗
PubMedDate not supplied

[The characteristics of the wound-healing action of solubilized alpha-tocopherol acetate].

The rat experiments were made to compare the wound-healing action of solubilized (aqueous) alpha-tocopherol acetate (SATA) prepared by the original techniques and its official oil-based preparation. A course intravenous SATA (2 mg four times at an interval of 4 days) administration was found to stimulate epithelial regeneration and suppress the formation of connective tissue of uncomplicated skin wounds. By healing the complicated wounds, SATA potentiated the occurrence of an inflammatory reaction and slowed down regeneration, whereas its oily solution failed to produce this effect.

Animals↗
PubMedDate not supplied

[Possibilities of the use of surgical laser irradiation in spontaneous formation of cartilage tissue in ENT plastic surgery].

The experiments were made to study CO2-laser ability to promote spontaneous formation of nasal septum cartilage. Laser-induced changes in physical and histological characteristics of the cartilage tissue were followed up. Optimal regimens of radiation were selected which allowed to modify cartilage shape without impairment of its morphological and histological structure. In vivo tests were performed on rabbit auricular floor cartilage. The present shape of the cartilage remained stable. It is inferred that laser energy may be a promising tool in plastic ENT surgery.

Animals↗