Biomedical subjects

A B Shneider

Publications and source records attributed to A B Shneider.

3 recordsLinked to original sources

PubMed1991

Phenomenon of the adaptive stabilization of sarcoplasmic and nuclear structures in myocardium.

In adaptation of rats to repeated stress exposure, a mechanism gradually forms at the level of heart to provide a considerable increase in the organ resistance to reperfusion paradox and toxic concentrations of catecholamines and Ca2+. Sarcoplasmic reticulum and mitochondria isolated from the hearts of adapted animals are highly resistant to autolysis, and nuclei to the damaging action of one-chain DNA. These changes are named phenomenon of the adaptive stabilization of structures (PhASS). An important role of myocardial heat shock protein (HSP) accumulation in the mechanism of PhASS is shown. The development of PhASS is accompanied by an increased resistance of myocardium to ischemic necrosis.

Adaptation, Physiological↗

PubMed1991

[Adaptive stabilization of myocardium under the influence of electroacupuncture and cardiac protection].

Adaptation of animals to short-term stress is known to result in the development of the adaptive structure stabilization phenomenon. At the level of the heart, the phenomenon appears as increased resistance to elevated catecholamine and calcium levels, reperfusion paradox. This study attempted to reproduce the phenomenon without applying any stress, but using a course of transauricular electric acupuncture. The isolated hearts of rats undergoing a course of the acupuncture were ascertained to show a clear-cut high resistance to the reperfusion paradox. After coronary ligation, the extent of necrosis in the animals having the acupuncture was significantly lower, as in those adapted to stress. The assumption that the phenomenon forming the basis for cardioprotective effects develops with electric acupuncture is discussed in the paper.

Adaptation, Physiological↗

PubMed1991

Thiamine cardiotropism.

Thiamine administration (200 mg/kg 2 hours before start of the experiment) substantially reduced the myocardial ischaemic lesion in a model of experimental myocardial infarction in the rat. As shown by stereometric analysis of histological heart preparations, the cytoprotective action of vitamin B1 is mediated by increased cardiomyocyte resistance towards ischaemia, i.e., through an adequate increase in the relative volume of the protection zone. Experiments on a model of emotional-painful stress in the rat show that the antiischaemic action of vitamin B1 cannot be explained by a specific cardiotropism of thiamine (the presence of thiamine phosphate buffer depots excludes the manifestation of coenzymatic effects of thiamine under given conditions) but by an antistressor action of thiamine resulting in exclusion of an important pathogenetic link in the mechanism of stress-conditioned cardiopathy.

Animals↗