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A B Syrkin

Publications and source records attributed to A B Syrkin.

At least 19 recordsLinked to original sources
PubMed1993

[ICO-166 monoclonal antibodies against the CD45RA antigen].

Monoclonal antibodies (MCA) ICO-166 against CD45RA antigen were generated and characterized. In the indirect IFA, MCA ICO-166 reacted with 54.1 +/- 1.9% lymphocytes of human peripheral blood and 15.2 +/- 2.3% monocytes but not with granulocytes or thrombocytes. The method of double labelling of cells demonstrated that MCA ICO-166 detected all B-lymphocytes, all NK-cells and 31% of mature T-lymphocytes but only 55% of CD8 suppressor cells and only 21% of CDA helper cells carried this antigen on the surface. Experiments were carried out to block binding of FITC-labeled MCA ALB11 against CD45RA antigen with human lymphocytes by pretreatment of cells with different concentrations of MCA ICO-166. Treatment of cells with MCA ALB11 blocked binding of MCA ALB11-FITC by 85% on the average. MCA ICO-166 blocked binding of MCA ALB11-FITC by 66% on the average. When different dilutions of MCA ICO-166 were used, the dose-dependent effect of blocking of MCA ALB11-FITC binding was observed. MCA ICO-166 immunoprecipitated a protein band of molecular weight 220 kDa from lysates of mononuclear cells of the human peripheral blood.

Animals↗
PubMed1990

[Dextran-ferrite distribution in the body of animals in a nonuniform permanent magnetic field].

Dextran-ferrite (DF) was injected via the femoral artery to the dogs and followed by local magnetization (induction 0.3 T, grade 0.024 T/cm). It has been shown that the local retention of the iron in some tissues of the leg was 3-5 times as high as the control. The magnetization did not increase the local retention of the iron after intravenous injection of DF to mice and rabbits.

Animals↗
PubMed1988

[Antidotal and antineoplastic properties of copper sulfate].

Copper sulfate in peroral administration to small experimental animals has an inhibitory effect on the growth of transplanted solid tumors and possesses antidote properties in respect to cisplatin. An antitumor effect of the compound was registered at doses ranging from 10 to 120 mg/kg. Antidote properties are manifested clearly when copper sulfate is applied at a single dose 10 mg/kg, 24 hours before cisplatin administration. It has been determined that copper sulfate decreases acute toxicity, nephro- and hemotoxicity of cisplatin, but fails to change its antitumor effect. The experimental data obtained give the ground for the clinical studies of copper sulfate.

Animals↗
PubMed1987

[Antitumor and toxic effects of amotin].

An indole alkaloid isolated from Catharanthus roseus in the Soviet Union and named amotin differs in terpenoid moiety structure of the indole part of the molecule from the foreign preparation vinblastine and its Soviet analog rosevine. In experimental study amotin has exhibited a high antileukemic activity which was more expressed than that of vinblastine. Tolerant doses of amotin cause moderate reversible morphological alterations in hematopoietic organs, gastrointestinal mucosa, liver, kidney, adrenals, testes, ovaries.

Animals↗
PubMed1986

[Effect of the induction and inhibition of liver monooxygenases on the toxic and therapeutic action of vincristine].

The influence of phenobarbital and ziksorin, liver monooxygenase inductors and the influence of inhibitor SKF 525-A on the toxic and therapeutic effects of vincristine were studied on CBA and C57Bl mice (with hemoblastosis La or intact). It was shown that acute toxicity and therapeutic activity of vincristine lowered on induction of the liver monooxygenases, whereas inhibition of this enzymatic system resulted in increased toxicity and lowered therapeutic activity of vincristine. The possible use of these results in treatment of cancer patients is discussed.

Animals↗
PubMed1985

[Mitigation of cisplatin toxicity by the complexon tetacin-calcium].

A possibility to decrease toxic properties of intraperitoneally injected platidiam (cis-platin, CSSR) administered by means of edtacal, a complexon (tetracinium-calcium, CSSR), administered per os is studied. It is established in intact mice that administration of edtacal simultaneously with platidiam or 1 h before decreases the mortality rate, diarrhea incidence and animal body mass loss. Edtacal is shown to have also an antiemetic action. Edtacal administered simultaneously with platidiam as well as 1 and 3 h before its injection does not decrease the antitumour activity of the preparation in (C57B1 X CBA)F1 mice with the Ehrlich ascite carcinoma.

Animals↗
PubMed1985

[Effect of phenobarbital and SKF 525-A on the toxic and therapeutic action of adriamycin in mice with Ehrlich ascites cancer].

The toxic action of adriamycin (AD) in mice with the ascitic Ehrlich carcinoma was reduced by preliminary administration of phenobarbital (PB), an inductor of liver monooxygenases, and was increased after administration of SKF 525-A, an inhibitor of this enzymatic system. PB and SKF decrease the therapeutic action of AD. Incidentally, induction or inhibition of the liver enzymes was equivalent to the decrease in the AD dose in mice with the intact liver. It was also shown that the essence of PB and SKF influence on the AD therapeutic effect is its action on liver monooxygenases activity and not the interaction between PB or SKF and AD or the change of AD sensitivity of tumour cells. The possible role of cytochrome P-450 in manifestation of the AD toxic and therapeutic activity is discussed. The authors believe that for prevention of AD toxicity in patients with liver disorders the treatment following stimulation of the liver metabolic activity up to the normal liver level may be effective.

Animals↗
PubMed1985

[New concepts of microsomal metabolism of the antibiotic adriamycin].

Experimental and literary data are presented which are at variance with the known conception of adriamycin (AD) shunting the chain of microsomal electron transfer. AD, carminomycin, rubomycin, mitomycin C, and coenzyme Q9 are shown to interact with NADPH, in the absence of enzymes, with the nucleotide oxidation. A new scheme of AD metabolism is suggested, according to which AD in the hydroquinone form enters the chain of electron transfer in microsomes between NADPH and flavoprotein.

Cytochrome P-450 Enzyme System↗
PubMed1984

[Potentiation by blastolysin of the effect of cyclophosphamide in preventing recurrence in mouse T-cell leukemia].

Injection of cyclophosphamide in a dose of 100 mg/kg two or four times at 18- or 7-day intervals, respectively, prolonged the remission in EL-4-leukemia-bearing C57Bl/6j mice induced by cytosar under deoxycytidine protection. Injection of blastolysin in a dose of 25 mg/kg once a week at the same period had no effect. However, blastolysin potentiated the antirelapse effect of cyclophosphamide. It is suggested that the potentiation of the cyclophosphamide effect with blastolysin is mediated by activation of antitumor immunological reactivity.

Animals↗
PubMed1984

[Antineoplastic and toxic effects of blastolysin in the treatment of spontaneous mammary cancer in dogs].

The anticancer activity and toxicity of blastolysin were studied in 13 dogs with mammary cancer using two different schedules. The agent was given 5 times in a dose of 2.5-10 mg/kg with a 72 h interval (the first schedule) and 10 times in a dose of 0.4-1.7 mg/kg in 24 h (the second schedule). The first schedule exhibited the highest anticancer effect with the least toxicity. Blastolysin was found to depress erythropoiesis.

Animals↗