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Biomedical subjects

A Bán

Publications and source records attributed to A Bán.

18 recordsLinked to original sources
PubMed1994

[Retinoids in the therapy of diseases of the hematopoietic system and malignant tumors].

The antitumor effect of different retinoids focused attention in the treatment of malignant disorders on different pathways. The therapeutic effect was proved in acute promyelocytic leukaemia, but was limited in juvenile form of chronic myeloid leukaemia and in acute myelomonocytic and monoblastic leukaemia. Combined with different leukostatics, long remission could be achieved. The most important therapeutic pathway is direct growth inhibition with and without cell differentiation. Clinically, retinoids are effective in tumours, like: cutan T-cell lymphoma, mycosis fungoides, Sézary syndrome, oral leukoplakia (prevention of head and neck cancer metastases), variant form of small lung cell carcinoma, oestrogen dependent breast-carcinoma and cervix-carcinoma. The most serious complication of the retinoids' administration is the retinoic acid syndrome which is followed sometimes with thromboembolic events. Retinoids are teratogenic and hepatotoxic.

Blood Coagulation Disorders↗
PubMed1986

[Cytology of bone marrow metastases of malignant tumors].

It is reported on the bone marrow involvement of 389 malignant tumors investigated by sternal marrow aspiration. The frequency of skeletal metastases as revealed by routinely taken bone marrow aspiration was 20.3%. Bone marrow metastases were detected mostly in tumors of prostatic, pancreatic, renal and ovarian origin, in cancers of the breast and in melanoblastoma. Positive cytological findings increased to 29.0% in those metastatic tumors, where the frequency of metastases had been identified with clinical and different laboratory methods. In cases, where these methods detected the primary tumor only, the metastatic frequency was 13.4% in form of micrometastases, invisible by x-ray examination. The cell type of the metastatic tumor did not allow to localize the primary site of the disease. Non-specific reactions as eosinophilia and microgranuloma, both increased, are not specific but suspicious of skeletal metastases.

Biopsy, Needle↗
PubMed1985

[Occurrence and clinical course of drug-induced agranulocytosis].

A report of 27 drug induced agranulocytosis is presented in a period of 13 years. The rate of the disease was 0.12% of the total number of patients. Cases due to cytostatical and radiation treatment were not included. According to bone-marrow cellularity patients were divided into hypo- and hyper-cellular groups. The clinical findings were similar in both groups and the majority of patients recovered. Two patients died, both in the hypocellular group: the first due to mycotic pulmonary infection, the other after massive pulmonary embolism but after complete haematological recovery. Bone-marrow plasmocytosis was slightly expressed in the hypocellular group. The normal leukocyte number appeared after treatment within 3-25 days. Recurrent agranulocytosis was observed in four patients and permanent leukopenia developed in five. The leukocyte-agglutination test was positive in 10 cases only, but the leukocyte migration test was positive in all investigated cases except two. Five patients had a previous history with idiosyncrasy. Treatment was started with antibiotics, corticosteroids and with antimycotic drugs. Sterile island and granulocyte-transfusion was applied in seriously ill patients with septicemic complications only.

Adolescent↗
PubMed1984

[Long-term treatment with coumarin preparations in advanced age].

It is reported on the occurrence of haemorrhagic complications at old age in patients treated with coumarin. Altogether 352 patients were examined, 96 of them were older than 70 years. A small part of the patients, above all men with obliterating vascular occlusions of the lower extremity were additionally given also thrombocyte aggregation inhibitors. The effective prothrombin level was nearly the same in the two, groups, i.e. in the patients younger and older than 70 years. There was no difference in frequency and severity of the haemorrhages with the exception of macrohaematuria which, however, appeared above all in the younger age group and in women older than 70 years. Under observation of the indications and with a regular control a long-term treatment with coumarin preparations can performed without any particular risk also at old age.

Acenocoumarol↗