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Biomedical subjects

A Bès

Publications and source records attributed to A Bès.

29 records · Page 2Linked to original sources
PubMed1982

[Dopaminergic hypersensitivity in migraine: a diagnostic test? (author's transl)].

A dopaminergic agonist, piribedil, was administered by intravenous infusion (0.1 mg/kg over 30 minutes) to 20 patients known to suffer from migraine and 20 subject free from any kind of headache. Neither changes in cerebral blood flow (CBF), as measured by the 33Xenon inhalation technique, nor peripheral side-effects were noted in the control group. Patients with migraine exhibited an 18 p. cent increase in CBF and a 32 p. cent decrease in mean arterial pressure and rapidly developed nausea severe enough to discontinue the infusion in most cases. Prior administration of domperidone, a neuroleptic drug which does not cross the blood-brain barrier, suppressed the nausea and fall in blood pressure but had no effect on the increase in CBF. This study confirms the existence of central and peripheral hypersensitivity to dopaminergic agents in patients with migraine. The piribedil test could be used to distinguish genuine migraine from ordinary cephalalgia in patients prone to headache.

Cerebrovascular Circulation↗
PubMed1982

Cerebral circulatory effects of a dopaminergic agonist (apomorphine) in the dog.

Dopaminergic influence upon cerebral circulation was studied in 12 adult mongrel dogs, local cerebral blood flow (lCBF) being measured by the microspheres method. The intravenous injection of apomorphine (0.1 mg/kg) produced heterogeneous effects on lCBF; an increase in lCBF reaching the level of statistical significance was observed in frontal and sensory motor cortices, whereas blood flow was not significantly altered in the other regions examined. When the animals are considered individually, a widespread response was generally observed. Local cerebral blood flow increased from 16% to 85% (depending on the regions examined) in 4 animals, and tended to decrease (particularly in the caudate nucleus) in the 8 others. These opposite effects cannot be related with changes in general metabolic or hemodynamic parameters (PaCO2, PaO2, pH, and arterial pressure). It is thus concluded that the effect of dopaminergic stimulation upon cerebral circulation is more complex than previously reported. These effects could only be partly mediated via vascular receptors and could be the result of modifications of the local metabolic level.

Animals↗
PubMed1978

[Peripheral neuropathy with cryoglobulinemia (author's transl)].

The author describe 2 personal observations of peripheral neuropathy with cryoglobulinemia and the 28 cases previously recorded are reviewed. The characteristics of the usually sensorimotor neuropathy are not specific. Nevertheless, the association with purpura, Raynaud's syndrome and leg ulcers and the inconstant aggravation of the symptoms with cold allow the diagnosis to be suspected on clinical grounds. Cryoglobulin can be recognised by immunoelectrophoresis and classified as type I monoclonal, types II and III mixed and polyclonal. Associated disease should be looked for; lymphocytic proliferation or auto-immune disease. If none is found a diagnosis of essential cryoglobulinemia can be made but with caution as cryoglobulinemia can precede by several years the appearance of associated disease.

Aged↗
PubMed1978

[Pseudo-tumoral softening of the cerebellum].

The author establish an onerall picture of cerebellar infarction with brain stem compression after reviewing 63 cases published in the literature and 4 personal observations. The frequency of this affection can be compared with that of cerebellar hematomas. Diagnosis is based on its predominance in males, the early age at which it appears, its rapid and typical onset, and the delayed signs of brain stem compression. Conventional neuroradiological procedures show an expanded cerebellar volume, and the scanner can specify the ischaemic nature of the lesion. As soon as changes in consciousness occur surgical decompression is necessary, first by external drainage of C.S.F. and later, if necessary, by direct access to the postdrior fossa.

Adult↗
PubMedDate not supplied

Cortical atrophy in Parkinson disease: correlation between clinical and CT findings with special emphasis on prefrontal atrophy.

Thirty-seven patients with Parkinson disease were evaluated clinically and with computed tomography in order to determine the incidence of prefrontal atrophy. An age-matched healthy control group was also scanned. The computed tomographic criteria used were the width of cortical sulci and ventriculocerebral indices. Parkinsonian patients with frontal cortical atrophy represent only one patient out of three. They are much older than parkinsonian patients with normal computed tomographic scans, and the onset of their illness occurs later. No significant difference was found according to gender, parkinsonian clinical triad, psychomotor study, or mean duration of illness and/or dopatherapy to the time of computed tomography. This work seems to separate two Parkinson diseases: one beginning before 65 years and damaging the nigrostriate system, and another beginning after 65 years and damaging both the nigrostriate system and the cortex, particularly the frontal cortex.

Aged↗