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Biomedical subjects

A Bahloul

Publications and source records attributed to A Bahloul.

At least 19 recordsLinked to original sources
PubMed1999

[Multifocal tubulopapillary tumors of the kidney. Morphologic features and prognosis. Three cases].

Tubulopapillary tumors of the kidney represent a particular group of renal tumors characterized by their less aggressive behavior. These tumors are distinguished from non papillary tumors by their morphologic, cytochemical and genotypic features. They correspond to a continuous spectrum of tumors ranging from papillary renal cell adenoma to papillary renal cell carcinoma. These TTPR show multifocal, bilateral development and chronic lesions of the kidney parenchyma in nearly all cases. The authors report three cases of multifocal TTPR, including one bilateral case. Based on analysis of these cases and a review of the literature, they discuss the histogenetic features and prognosis of TTPR.

Adenocarcinoma, Papillary↗
PubMed1998

Increased expression of a hemimethylated oriC binding protein, SeqA, in an aphA mutant.

In Escherichia coli, the origin of DNA replication, oriC, becomes transiently hemimethylated at the GATC sequences immediately after initiation of replication and this hemimethylated state is prolonged because of its sequestration by a fraction of outer membrane. This sequestration is dependent on a hemimethylated oriC binding protein such as SeqA. We previously isolated a clone of phage lambda gt11 called hobH, producing a LacZ fusion protein which recognizes hemimethylated oriC DNA. Very recently, Thaller et al. (FEMS Microbiol. Lett. 146 (1997) 191-198) found that the same DNA segment encodes a non-specific acid phosphatase, and named the gene aphA. We show here that the interruption of the aphA reading frame by kanamycin resistance gene insertion, abolishes acid phosphatase (NAP) activity. Interestingly, in the membrane of the null mutant, the amount of SeqA protein is about six times higher than that in the parental strain, suggesting the existence of a regulatory mechanism between SeqA and NAP expression.

Acid Phosphatase↗
PubMed1997

[The pathological prostatic utricle: two case reports].

The prostatic utricle is a small vestigial diverticulum on the posterior surface of the prostatic urethra. It is considered to be pathological when it is abnormally dilated. The prostatic utricle is revealed by signs of vesical irritation and dysuria, sometimes associated with a retrovesical mass on examination. The authors report two cases of pathological prostatic utricle. The first case was an 11-year-old boy presenting with dysuria. Retrograde cystourethrography confirmed the diagnosis. The utricle was resected via a transtrigonal intravesical approach. The second case was a 25-year-old man who presented with dysuria associated with a pelvic mass. IVU and ultrasonography suggested a diagnosis of retrovesical cyst. This patient underwent incomplete resection of the utricle via a retrovesical approach. Based on a review of the literature, the authors emphasize the need to look for a prostatic utricle in a young subject presenting with dysuria, particularly in patients with a malformation of the genitourinary tract (hypospadias, renal agenesis). All pathological prostatic utricles must be treated surgically. The incision is transtrigonal in medium-sized utricles and transperitoneal in large utricles. The utricular cavity must be resected as completely as possible.

Adult↗
PubMed1997

[Renal cell adenocarcinomas. Report of 64 cases].

The authors report 64 renal cell carcinomas observed in 64 patients over a period of 14 years (1982-1995). The mean age was 58 years (range: 20 to 80 years). Male involvement was observed in 34 cases (53%). The clinical symptoms were nonspecific, consisting of haematuria (26 cases), back pain (33 cases) and tumour (8 cases). Twenty patients presented with paraneoplastic syndromes and 4 presented with metastases. The tumour was an incidental finding in 6 cases. Fifty two patients were treated by radical nephrectomy and two by partial nephrectomy. The tumour was associated with venous involvement in 2 cases, lymphatic involvement in 4 cases and distant metastases in 2 cases. The overall 5-year survival was 37% with a poor prognosis in the case of lymph node involvement or metastases and in the case of secondary local recurrence (4 cases) or distant metastases (2 cases).

Adult↗
PubMed1997

[Kidney contusions and traffic accidents. Apropos of the Tunisian experience].

The authors report a retrospective series of 45 cases of blunt renal trauma from a total of 685 cases of blunt abdominal trauma observed between 1989-1993. This multicentre trial was designed to illustrate the severity of this type of trauma and to place it in the context of road accidents in Tunisia.

Abdominal Injuries↗
PubMed1997

[Contusions to the pathologic kidney. A retrospective study, apropos of 34 cases].

The authors report a retrospective study of 34 cases of blunt renal trauma affecting a pathological kidney out of a total of 156 cases of renal trauma. The patients were between the ages of 3 and 60 years, with a male predominance (sex-ratio: 2.4). The predominant cause of trauma was a household accident, in 15 cases (44%). The clinical features were dominated by haematuria and pain. The underlying renal disease was dominated by renal stones (15 cases, 44%) and ureteropelvic junction (UPJ) abnormality (10 cases, 29%). Twelve patients with benign trauma and minimal underlying renal disease were treated conservatively. Surgery was indicated in the remaining 22 patients, but only 20 were actually operated. Nephrectomy was performed in 9 patients and partial nephrectomy was performed in 3 patients. Treatment consisted of UPJ plasty in 2 cases, uretero-caliceal anastomosis in one case, stone surgery in 4 cases and suture of ruptured renal pelvis in one case. The postoperative course was marked by the development of a urinary fistula in 1 patient, cured by drainage and deterioration of hydronephrosis in one patient. Lastly, one patient died from Wilms' tumour. This disease therefore tends to have a fairly benign course, which nevertheless depends on the underlying renal disease.

Accidents, Home↗
PubMed1997

[Kidney injuries in children. Apropos of 65 cases].

The authors report a retrospective series of 65 cases of renal contusion in children affecting 45 boys and 20 girls between the ages of 10 months and 15 years (mean age: 10 years). The causes of renal trauma were dominated by household accidents (53.8%) and road accidents (33.8%). Associated extrarenal lesions were observed in 21.5% of cases. 55.4% of the 65 contusions were considered to be benign, 27.7% of moderate severity and 16.9% were serious. The blunt trauma affected a pathological kidney in 19 cases. Exclusively medical treatment was recommended in 31 patients, while surgery was indicated in the other 34 patients. Apart from one death in a context of multiple trauma, few complications were observed in the group of operated patients and consisted of 4 cases of urinary fistula and 4 cases of infection, all of which resolved.

Accidents, Home↗
PubMed1997

[Traumatic rupture of the anterior urethra. Apropos of 18 cases].

The authors report a retrospective series of 18 cases of rupture of the anterior urethra, with a mean age of 25 years (range: 10 to 45 years). The mechanism of the lesion was trauma by falling onto the perineum (12 cases), road accident (4 cases) and sexual intercourse (2 cases). Urine drainage was ensured by suprapubic catheter (15 cases) or urethral catheter (1 case). The two cases of rupture of the urethra associated with lesions of the corpora cavernosa required urgent surgical repair. In the other cases, simple urine drainage was sufficient to treat partial ruptures of the urethra (11 cases) with only one case of urethral structure. However, end-to-end urethrorraphy was performed in the 4 patients with total rupture of the urethra, with early failure in 3 cases, attributed to delayed surgery. Finally, the course of urethral rupture associated with rupture of the corpora, cavernosa was favourable in terms of both micturition and sexual function.

Accidents, Traffic↗
PubMed1996

Co-ordination between membrane oriC sequestration factors and a chromosome partitioning protein, TolC (MukA).

oriC DNA in the hemimethylated (but not in the fully methylated) state reacts with an Escherichia coli K-12 outer membrane preparation. This reaction is drastically reduced when the membrane preparation of a seqA null mutant is used. An in vitro reconstitution of the activity was undertaken by adding a partially purified SeqA protein to a seqA mutant membrane without success. A possible reason for this failure might be a profound modification of the outer membrane of the seqA mutant (as revealed by the fact that membrane from the mutant sediments more slowly than that from the wild type during ultracentrifugation). There is also a reduction in the content of OmpF protein. Moreover, one of the minor outer membrane proteins involved in partitioning of newly synthesized chromosomes, the ToiC (MukA) protein, was also found to be downregulated in the seqA mutant. This is also true of the hobH mutant grown in a high-osmolarity medium. Mutants of both seqA and hobH stop dividing after hyperosmotic shock, forming filaments (as observed in dam mutants).

Bacterial Outer Membrane Proteins↗
PubMed1996

[Adrenal cortex adenomas. A retrospective series of twenty cases].

The authors report 20 cases of adrenal cortex tumours which were collected over a period of 12 years (1984-1995). Sixty five per cent of patients were females. They were aged between 27 months and 85 years with a mean of 40 years. Clinical symptoms were dominated by hypertension (11 cases). Seven cases were discovered incidentally and a precocious puberty syndrome presented in the form of 2 cases. Surgery was performed in 18 cases. Adrenalectomy was performed in 16 cases and tumor removal in 2 others. Four patients underwent other procedures such as nephrectomy or splenectomy. Three adrenal tumors were considered to be malignant. Postoperative follow-up was marked by two deaths; otherwise the postoperative course was uneventful.

Adenoma↗
PubMed1996

[Adrenal pheochromocytoma. Report of six cases].

The authors report 6 cases of adrenal pheochromocytoma seen over a period of 3 years (1993-1995). All patients were females, aged between 17 and 43 years with a mean of 35 years. Clinical manifestations consisted of either sustained hypertension, with episodes of hypersudation and palpitations, or paroxysmal hypertension which was revealed during surgery ; the disease was sometimes discovered incidentally. C.T and ultrasound showed in every cases adrenal mass as 3 to 6 cm usually located on the left side (5 cases). All patients were operated via lumbotomy and adrenalectomy was performed. In one case an associated thrombus within the vena cava was removed. Postoperative follow-up was uneventful except for one patient who developed a recurrent episode of hypertension.

Adolescent↗
PubMed1996

[Bladder hernia apropos of a case report].

The authors report a case of bladder hernia associated to prostatic benign hyperplasia. The diagnosis is confirmed by intra-venous urogram and computed tomography imaging. The reintegration of the bladder in the abdomen was performed in association to endoscopic resection of the prostate. Bladder hernia is rare condition. Surgical treatment of bladder hernia is associated to the etiology (prostatic benign hyperplasia...) of the hernia to prevent recurrence.

Diagnostic Imaging↗
PubMed1996

[Bladder hernias].

The authors report 5 cases of bladder herniation through inguinal ring. All the patients were males aged between 52 and 72 years with a mean of 63 years. The clinic symptoms were non specific. In four cases the diagnosis was made by IVP. In the fifth case the bladder herniation was discovered after an incidental opening of the bladder during a right inguinal hernia repair. Four patients were operated on for replacement of the bladder and repair of the hernial ring; the procedure followed was Mac Vay technique in two cases, Shouldice in one case and placement of a Mersuture prosthesis in another case. The fifth patient was operated on because of major constraint related to his general conditions. Results was quite satisfactory in all operated cases with a mean control of 24 months.

Aged↗
PubMed1995

Importance of the replication origin sequestration in cell division of Escherichia coli.

The DNA adenine methyltransferase of Escherichia coli methylates adenines at GATC sequences. The mutant deficient in this methylase has no apparent deficiency in the cell division process in spite of the absence of both synchrony in initiations of chromosomal DNA replication and sequestration of replication origin (oriC) at hemimethylated state. However, the dam mutant cannot resume cell division after hyperosmotic shock differing from the wild-type strain. This inhibition is not provoked by induction of the cell division inhibitor, SfiA protein. Although the FtsZ protein is present in the dam mutant in a reduced amount compared to wild-type, the quantitative difference of this protein is not the main reason of division arrest provoked by hyperosmotic shock. This observation supports the idea of oriC-membrane interaction playing a role both in chromosome partitioning and cell division as predicted by replicon theory.

Bacterial Proteins↗
PubMed1995

[Hydatic cyst of the kidney. Eighteen cases].

18 patients with 18 hydatid cyst of kidney, underwent surgical intervention from 1982 to 1994. There were 6 men in the series and 12 women who ranged in age from 7 to 65 years (mean 38 years). Flank pain was the chief complaint (55%). Abdominal mass was detected on physical examination in 38% of cases. Ultrasonographic examination, performed in all cases, made a correct diagnosis in 13 patients (72%). Excretory urogram (IVP), performed in 9 patients, showed signs of benign tumor process. All patients were operated on: the procedures performed included 12 resection of "protruding dome", 1 total nephrectomy, 3 partial pericystectomy, 2 total pericystectomy, 1 total nephrectomy. In postoperative course, there was one death (5.5%) and morbidity was 11%. We conclude that hydatid cyst of kidney still rare but possible in endemic areas; its treatment, usually surgical, still difficult because it should avoid recurrence of hydatic disease without sacrifice of the kidney.

Adolescent↗
PubMed1995

[Cancer of the testis in cryptorchidism. Apropos of 5 cases].

Five cases of cancer of the testicle in patients with cryptorchidism are presented. In one case the tumour occurred 16 years after cure for cryptorchidism at 15 years of age. In the other cases, the tumour developed on a testicle in an inguinal or intra-abdominal position. In two cases, it was impossible to remove the tumour which had developed on an intra-abdominal position. These patients died. These cases emphasize the importance of surgical cure in all cases of cryptorchidism, preferable before the age of 2 years, in order to improve functional prognosis and reduce the risk of cancerization. The gravity of cancer of the testicle in cases of cryptorchidism is often discovered too late.

Adult↗
PubMed1995

[Urinary calculi in a geriatric setting].

The authors report a retrospective series of 174 patients with urolithiasis. They were all age between 65 and 88 years. This group represents one tenth of all patients treated for urinary stones in the Urology department of Sfax over the last decade. Neither the clinical symptoms nor radiological findings observed in this group differed from those other patients hospitalized for urolithiasis; on the other hand associated diseases related to aging appear to be well represented which alters the management, prognosis and outcome in this type of patients.

Aged↗