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Biomedical subjects

A Baldassarri

Publications and source records attributed to A Baldassarri.

13 recordsLinked to original sources

Brownian forces in sheared granular matter.

We present results from a series of experiments on a granular medium sheared in a Couette geometry and show that their statistical properties can be computed in a quantitative way from the assumption that the resultant from the set of forces acting in the system performs a Brownian motion. The same assumption has been utilized, with success, to describe other phenomena, such as the Barkhausen effect in ferromagnets, and so the scheme suggests itself as a more general description of a wider class of driven instabilities.

Journal Article↗

Self-stabilized fractality of seacoasts through damped erosion.

Erosion of rocky coasts spontaneously creates irregular seashores. But the geometrical irregularity, in turn, damps the sea waves, decreasing the average wave amplitude. There may then exist a mutual self-stabilization of the wave amplitude together with the irregular morphology of the coast. A simple model of such stabilization is studied. It leads, through a complex dynamics of the earth-sea interface, to the appearance of a stationary fractal seacoast with a dimension close to 4/3. Fractal geometry here plays the role of a morphological attractor directly related to percolation geometry.

Biophysics↗

Multicenter trial for the set-up of a MRI quality assurance programme.

Many international protocols related to RMI-QC program are focused on acquisition methods and analysis of several image quality parameters but rarely normality ranges or measurement frequencies are presented. To address this problem we investigated the variability of many magnetic resonance imaging (MRI) systems with the set-up of multicenter trial. The trial was set up to investigate short-and mid-term variability of two fundamental nongeometric image quality parameters: signal-to-noise (SNR) and integral percent uniformity (U%). Ten centers (12 devices) participated to data collection consisting of a three-step-protocol. First, 10 consecutive images of a phantom were collected with a spin echo sequence. As second step the series collection was repeated 24 h later. Finally a single image acquisition was performed twice a week for 5 weeks. The analysis of results allowed us to define a "physiological" variability of +/-3% of the reference level for both parameters and to conclude that a weekly measurement is adequate to detect relevant variations of device performance.

Analysis of Variance↗

Fluctuation-dissipation relations in driven granular gases.

We study the dynamics of a two-dimensional driven inelastic gas, by means of direct simulation Monte Carlo techniques, i.e., under the assumption of molecular chaos. Under the effect of a uniform stochastic driving in the form of a white noise plus a friction term, the gas is kept in a nonequilibrium steady state characterized by fractal density correlations and non-Gaussian distributions of velocities; the mean-squared velocity, that is the so-called granular temperature, is lower than the bath temperature. We observe that a modified form of the Kubo relation, which relates the autocorrelation and the linear response for the dynamics of a system at equilibrium, still holds for the off equilibrium, though stationary, dynamics of the systems under investigation. Interestingly, the only needed modification to the equilibrium Kubo relation is the replacement of the equilibrium temperature with an effective temperature, which results equal to the global granular temperature. We present two independent numerical experiments, where two different observables are studied: (a) the staggered density current, whose response to an impulsive shear is proportional to its autocorrelation in the unperturbed system and (b) the response of a tracer to a small constant force, switched on at time t(w), which is proportional to the mean-square displacement in the unperturbed system. Both measures confirm the validity of Kubo's formula, provided that the granular temperature is used as the proportionality factor between response and autocorrelation, at least for not too large inelasticities.

Journal Article↗

Cooling of a lattice granular fluid as an ordering process.

We present a microscopic model of granular medium to study the role of dynamical correlations and the onset of spatial order induced by the inelasticity of the interactions on the velocity field. In spite of its simplicity and intrinsic limitations, it features several aspects of the rich phenomenology observed in granular materials and allows to make contact with other topics of statistical mechanics such as diffusion processes, domain growth, aging phenomena. Interestingly, while local observables, being controlled by the largest wavelength fluctuations, seem to suggest a purely diffusive behavior, the formation of spatially extended structures and topological defects, such as vortices and shocks, reveals a more complex scenario. Finally, only for quasielastic systems, we observe a neat scale separation, which represents a fundamental hypothesis to develop a granular hydrodynamics.

Journal Article↗

Coarsening and slow dynamics in granular compaction.

We address the problem of the microscopic reorganization of a granular medium under a compaction process in the framework of Tetris-like models. We point out the existence of regions of spatial organization which we call domains, and study their time evolution. It turns out that after an initial transient, most of the activity of the system is concentrated on the boundaries between domains. One can then describe the compaction phenomenon as a coarsening process for the domains, and a progressive reduction of domain boundaries. We discuss the link between the coarsening process and the slow dynamics in the framework of a model of active walkers on active substrates.

Journal Article↗

Driven granular gases with gravity.

We study fluidized granular gases in a stationary state determined by the balance between external driving and bulk dissipation. The two considered situations are inspired by recent experiments, where gravity plays a major role as a driving mechanism: in the first case, gravity acts only in one direction and the bottom wall is vibrated; in the second case, gravity acts in both directions and no vibrating walls are present. Simulations performed under the molecular chaos assumption show averaged profiles of density, velocity, and granular temperature that are in good agreement with the experiments. Moreover, we measure velocity distributions that show strong non-Gaussian behavior, as experiments pointed out, but also density correlations accounting for clustering, at odds with the experimental results. The hydrodynamics of the first model is discussed and an exact solution is found for the density and granular temperature as functions of the distance from the vibrating wall. The limitations of such a solution, in particular in a broad layer near the wall injecting energy, are discussed.

Journal Article↗

Influence of caloric intake on gastric emptying of solids assessed by 13C-octanoic acid breath test.

BACKGROUND: The 13C-octanoic breath test (13C-OBT), a recently developed technique to evaluate gastric emptying of solids, has been validated in comparison to scintigraphy with low caloric meals (250 kcal). However, there is consensus that for clinical studies total caloric load should be in excess of 300 kcal, but studies comparing 13C-OBT results after low and medium caloric meals are lacking. METHODS: Ten healthy subjects were given a 250-kcal and a 550-kcal meal in randomized order. Gastric emptying was assessed simultaneously by ultrasonography and 13C-OBT. Breath samples were taken according to both classic (21 samples over 5 h) and simplified (11 samples) schedules. RESULTS: Increasing the meal energy content resulted in significantly longer half emptying time (T(1/2)) estimates by both ultrasonography (P < 0.01, Wilcoxon test) and 13C-OBT (P < 0.05). T(1/2) estimates by the two methods significantly correlated for both the 250 (r(s) = 0.733, P = 0.018) and the 550 (r(s) = 0.637, P = 0.035) kcal meal. However, differences between T(1/2) estimates by 13C-OBT and ultrasonography were greater after the 550- than the 250-kcal meal (median 172.5 versus 76.5 min, P < 0.05). Interindividual variability was also 2-fold greater for indexes estimated by 13C-OBT with the 550-kcal meal compared with the 250-kcal meal. For both meals 13C-OBT yielded similar results with the classic and simplified schedules. CONCLUSIONS: In healthy subjects caloric intake is a major determinant of gastric emptying rate. However, after a medium caloric meal 13C-OBT shows some inaccuracy, which raises questions about its routine clinical application. Nevertheless, when using 13C-OBT one must take into account that the simplified schedule is just as effective as the classic one, and is far lower in cost.

Adult↗

Surface hardening and self-organized fractality through etching of random solids

When a finite volume of etching solution is in contact with a disordered solid, complex dynamics of the solid-solution interface develop. If the etchant is consumed in the chemical reaction, the dynamics stop spontaneously on a self-similar fractal surface. As only the weakest sites are corroded, the solid surface gets progressively harder and harder. At the same time, it becomes rougher and rougher uncovering the critical spatial correlations typical of percolation. From this, the chemical process reveals the latent percolation criticality hidden in any random system. Recently, a simple minimal model was introduced by Sapoval et al. to describe this phenomenon. Through analytic and numerical study, we obtain a detailed description of the process. The time evolution of the solution corroding power and of the distribution of resistance of surface sites is studied in detail. This study explains the progressive hardening of the solid surface. Finally, this dynamical model appears to belong to the universality class of gradient percolation.

Journal Article↗

Magnetic resonance imaging of the submandibular-sublingual complex.

The submandibular-sublingual complex (SSC) was studied in vivo by magnetic resonance imaging (MRI) at 4.7 and 7.05 Tesla in rat and mouse. A correlation was found between histology and MRI signal. The mainly mucous sublingual gland emitted a more intense signal than the mainly serous submandibular gland. Ventral to the glands, cutis, subcutaneous adipose tissue and two planes of muscular tissue separated by connective laminae were visible in vivo. Autopsy and histology confirmed the in vivo description provided by MRI. The reactivity of the salivary system after pharmacological stimulation was studied in mice at 7.05 Tesla. Stimulation of salivary secretion by pilocarpine nitrate injected in the subcutaneous space ventrally to the SSC resulted in an augmentation of the salivary liquid visible in the oral cavity by MRI. The diffusion of pilocarpine nitrate in the connective tissue located ventrally the SSC and in the glandular parenchyma was also followed in vivo. These results show that MRI is a potentially useful tool for studying the salivary glands in vivo.

Animals↗

Age-related modification in the thymus of rats and mice: an in vivo study by magnetic resonance. MR imaging of the thymus.

Techniques of magnetic resonance were used to investigate in vivo the normal thymus and its age-related modifications in small rodents. The data were compared with anatomical preparations and histological sections of the animals. The possibility to visualize modifications of the thymus in living organisms open new perspectives for the follow up of experimental manipulations on laboratory animals.

Age Factors↗