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Biomedical subjects

A Ban

Publications and source records attributed to A Ban.

At least 19 recordsLinked to original sources
PubMed1996

Defective anion transport and marked spherocytosis with membrane instability caused by hereditary total deficiency of red cell band 3 in cattle due to a nonsense mutation.

We studied bovine subjects that exhibited a moderate uncompensated anemia with hereditary spherocytosis inherited in an autosomal incompletely dominant mode and retarded growth. Based on the results of SDS-PAGE, immunoblotting, and electron microscopic analysis by the freeze fracture method, we show here that the proband red cells lacked the band 3 protein completely. Sequence analysis of the proband band 3 cDNA and genomic DNA showed a C --> T substitution resulting in a nonsense mutation (CGA --> TGA; Arg --> Stop) at the position corresponding to codon 646 in human red cell band 3 cDNA. The proband red cells were deficient in spectrin, ankyrin, actin, and protein 4.2, resulting in a distorted and disrupted membrane skeletal network with decreased density. Therefore, the proband red cell membranes were extremely unstable and showed the loss of surface area in several distinct ways such as invagination, vesiculation, and extrusion of microvesicles, leading to the formation of spherocytes. Total deficiency of band 3 also resulted in defective Cl-/HCO3- exchange, causing mild acidosis with decreases in the HCO3- concentration and total CO2 in the proband blood. Our results demonstrate that band 3 indeed contributes to red cell membrane stability, CO2 transport, and acid-base homeostasis, but is not always essential to the survival of this mammal.

Animals↗
PubMed1995

Increasing gallstone prevalence and cholecystectomy rate in a large Romanian town. A necropsy study.

To study whether the increasing prevalence of gallstone disease noted in a 100-year interval in a large Romanian town has continued in recent years, we analyzed all necropsies (5234) performed during 10 years (1983-1992) in Cluj-Napoca. Gallstone disease (GD) was defined as the presence of stones or the absence of the gallbladder due to cholecystectomy. The results obtained were compared to those of the previous 10-year period (1973-1982). We found a significant increase of GD both in men (6.9% to 9.8%) (P < 0.001) and women (17.1% to 21.7%) (P < 0.001). The ratio of women to men with GD decreased as compared to the first time period (1.4/1 vs 1.8/1). The actual age-standardized prevalence of GD was higher than that calculated for the first time period: 7.6% in men (5.0% in 1973-1982) and 16.9% in women (8.4% in 1973-1982) (P < 0.001). The necropsy cholecystectomy rate rose markedly; 42.1% of the GD men and 43.0% of the GD women had undergone operation during their life. The present study indicates a higher prevalence of GD in the Romanian town than previously found. The actual prevalence is comparable with that of other central European countries, but it is less than that found in England, Scotland, or Sweden.

Adult↗
PubMed1992

[Upper digestive hemorrhage in acute pancreatitis].

We proposed to investigate the following parameters regarding upper gastrointestinal hemorrhage occurring in the patients with acute pancreatitis: incidence, form of manifestation, severity, correlated to the clinical and morpho-pathological form of acute pancreatitis, cause (direct causality or morbid association). The study was carried out on the inpatients of the internal-medicine and surgery units over a period of one year. For sake of accuracy the study also included the cases submitted to necropsy over a period of 5 years. The practical experience has revealed that though gastrointestinal bleeding is not a frequent complication--9.1% in the patients with acute pancreatitis and 36.3% of the necropsied cases--it is often severe, which imposes the early recognition for its adequate management.

Acute Disease↗
PubMed1991

[Cephalic duodenopancreatectomy with preservation of the pylorus in treating a malignant tumor of Vater's ampulla].

The paper reports on the clinical observation of a patient with mechanical jaundice in which the biliary obstruction was caused by an ampulla of Vater. Cephalic duodenopancreatectomy with preservation of the pylorus was used. Distally the duodenum was excised to its intersection with the mesenteric vessels. For recovery of the digestive circuits, a loop excluded "en Y" à la Roux ascending transmesocolically was used. The anastomoses had the following stages: choledochojejunostomy (T-T) the most proximal; pancreatic-jejunal anastomosis (T-L); and the most distal, the duodeno-jejunal one (T-L). After surgery, the evolution was good, and the patient left the hospital with the wound cured. Starting from this observation, the authors discuss aspects connected with the technique of cephalic duodenopancreatectomy with or without preservation of the pylorus.

Adenocarcinoma↗
PubMed1987

Comparative prevalence of gallstone disease at 100-year interval in a large Romanian town, a necropsy study.

The prevalence of gallstone disease in a large Romanian town was determined on 6275 necropsies performed during a 10-year period (1973-1982). The "crude" prevalence of gallstone disease in women was 17.1% and in men, 6.9%. Age-standardized prevalence was 8.4% in women and 5.0% in men. This rate is lower than the prevalence of gallstones in northern or central European countries, but it is higher than that established in some southern countries of Europe. A comparison of the "crude" prevalence of gallstone disease was compared with that calculated for a similar 10-year period 100 years ago (1873-1882), on 1538 necropsies performed in the same town. Prevalence of gallstones rose significantly in a century (from a mean of 1.2% to 11.3%; P less than 0.001), a finding consistent with the concept that gallstone disease is a "disease of civilization."

Adult↗
PubMed1977

[The action of silymarin on Galactosamine-induced hepatitis in the rat (author's transl)].

The hepatoprotective action of Silymarin was studied in 65 male Wistar rats, prior to and following D-galactosamine intoxication. There was a marked reduction in the histological and ultrastructural changes in the nucleolus, nuclear membrane, mitochondria, granular and agranular endoplasmic reticulum and lysosomes of the liver cell and also in the Kupffer stellate cells. The reduction in glycogen and RNA loss was determined biochemically. The activities of many enzymes were kept constant (oxidoreductases, NADH2 diaphorase, G-6-phosphatase, Mg++ and K+/Na+-dependent ATPases, acid phosphatases).

Acid Phosphatase↗