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Biomedical subjects

A Barankay

Publications and source records attributed to A Barankay.

At least 55 records · Page 3Linked to original sources

[Reduction of whole blood requirements in coronary surgery with hemoseparation and isovolemic hemodilution].

Because of relative shortage of homologous stored blood, and the dangers of transmission infectious diseases and isoimmunisation, we tried to reduce blood requirement in cardiac surgery. In 139 patients undergoing coronary artery bypass surgery different techniques of autotransfusion were applied. A 52% reduction of whole blood transfusion compared to a control group of patients could be obtained by preoperative isovolaemic haemodilution. The application of haemoseparation reduced the amount of whole blood used by 55%. When the two techniques were combined the use of whole blood was reduced by 70% compared to the control group of patients. In contrast retransfusion of blood remaining in the oxygenator is not advisable because only a small amount of blood can be saved in this way and in addition it results in a higher risk of postoperative bleeding. Our results will be discussed reviewing the literature.

Blood Transfusion↗

Control of hypertension during cardiopulmonary bypass with urapidil and phentolamine.

The vasodilating effect of 6-(3-[4-(o-methoxy-phenyl)-piperazin-1-yl]-propylamino)-1,3-dimethyluracil (urapidil, Ebrantil) and phentolamine was investigated during extracorporeal circulation in patients undergoing coronary artery bypass (CABG) operations. To compare the vasodilating effect, 10 patients received 2 times 25 mg urapidil, and another 10 patients 2 times 5 mg phentolamine when mean arterial blood pressure (MAP) exceeded 100 mgHg. Both drugs caused a significant (p less than 0.01) decrease in mean arterial blood pressure and total peripheral resistance (TPR), using constant flow (Qecc). Central venous pressure (CVP), measured in the inferior vena cava, showed no significant change, while a marked volume loss (delta V) in the oxygenator was observed. There was no significant difference in the measured cardiovascular parameters in the two groups of patients. The peripheral vasodilating effect of urapidil, expressed in mg was found 5 times weaker than that of phentolamine. Urapidil was found effective in the treatment of hypertension during extracorporeal circulation.

Aged↗

Circulatory effects of pipecurium bromide during anaesthesia of patients with severe valvular and ischaemic heart diseases.

Circulatory effects of 2 beta,16 beta-bis-(4.-dimethyl-1'-piperazino)-3 alpha,17 beta-diacetoxy-5 alpha-androstane dibromide (pipecurium bromide, RGH-1106, Arduan) were investigated in severe cardiac patients during the induction of anaesthesia, in the course of nitrous oxide-oxygen anaesthesia and during extracorporeal circulation. In a dose of 0.05 mg . kg-1 the drug did not cause significant changes in any of the circulatory parameters studied. It is a safe muscle relaxant which can be used in patients with valvular and ischaemic heart diseases as well.

Androstane-3,17-diol↗

[Report on a partial necrosis of the tongue caused by an endotracheal tube (author's transl)].

The case is presented of a patient in whom, because of a bleeding submental arterio-venous haemangioma both external carotid arteries were ligated. IPPR via an endotracheal tube was required for 18 hours after operation. Local necrosis of the tongue developed as a result of pressure from the endotracheal tube. The patient became symptomfree after necretomy of the tongue.

Adult↗