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Biomedical subjects

A Barbour

Publications and source records attributed to A Barbour.

8 recordsLinked to original sources
PubMed1989

Molecular mimicry and Lyme borreliosis: a shared antigenic determinant between Borrelia burgdorferi and human tissue.

The pathogenesis of chronic manifestations in Lyme borreliosis, a disease induced by Borrelia burgdorferi, is at present unresolved. By testing monoclonal antibodies directed against various borrelia antigens, we found an antigenic determinant shared by the 41 kDa flagella protein and human tissue, especially prominent on myelinated fibers of human peripheral nerve, on nerve cells and axons of the central nervous system, as well as on certain epithelial cells (including joint synovia) and on heart muscle cells. Immune reactions against such a shared antigen could play a pathogenetic role in chronic organ manifestations of Lyme borreliosis.

Antibodies, Monoclonal↗
PubMed1978

Mother-child interaction in high-risk and contrast preschoolers of low socioeconomic status.

Children's activities with their mothers and the techniques used by mothers while interacting with their child were examined in older (30--46 months) and younger (12--27 months) low SES preschool children from high-risk (in terms of cultural-familial retardation) and contrast homes. Older high-risk children interacted less often with their mothers and spent less time in "highly intellectual" activities than did the contrast children. The mothers of older high-risk children, in comparison with the contrast group, engaged less often in didactic teaching, showed less encouragement of their child's activities, and their attempts to control their child's activities more often resulted in failure. The differences between younger high-risk and contrast groups however were nonsignificant. Implications for future home intervention programs for high-risk low SES children are discussed.

Age Factors↗