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Biomedical subjects

A Barrientos

Publications and source records attributed to A Barrientos.

138 records · Page 8Linked to original sources
PubMedDate not supplied

A 2 year evaluation of diabetic patients on continuous ambulatory peritoneal dialysis.

Nineteen diabetic patients with end-stage renal disease on CAPD were evaluated over a 2 year period. All but one patient was insulin-dependent, with a mean age of 47.7 years. Average time on CAPD was 16.1 months (range, 2-28 months). Thirteen patients were followed for more than 12 months, and nine for more than 18 months. The mean training period was 22.9 days. Good blood glucose control was obtained with intraperitoneal (IP) insulin in all of the patients. Mean blood glucose levels of 125 +/- 23.08 mg/dl were achieved with 103 +/- 38.5 U/day of regular IP insulin. Glycosalated hemoglobin decreased from a mean of 12.7 +/- 2.35% before CAPD to 10.08 +/- 0.97% during CAPD. Peritoneal creatinine clearance remained stable during the study period, with a concommitant decrease (P less than 0.001) in the mean residual renal creatinine clearance. The incidence of peritonitis was one episode per 7.8 patient-months. Average length of hospitalization was 33.24 days/year. Visual acuity remained stable after 1 year in 73% of the 26 eyes evaluated. No amputations were required in more than 2 years of follow-up. Actuarial survival was 100% at 1 year and 86% at 2 years, and the technique survival of CAPD was 91 and 79%, respectively. These results demonstrate that CAPD is a good dialysis procedure for treating diabetic patients with chronic renal failure, and it offers the advantage of controlling glycemia better than other dialysis methods.

Adult↗
PubMedDate not supplied

Tissue concentrations of doxorubicin in animal models with engrafted intraocular tumours.

The role of chemotherapy in the management of retinoblastoma remains unclear. In order to evaluate the responsiveness to conventional or experimental agents, a xenograft model had been developed, where human retinoblastoma is heterotransplanted to the anterior chambers of nude mouse eyes. Because doxorubicin had been found to be ineffective in therapeutic studies utilizing the model, experiments were conducted to evaluate the concentration of the drug in tissues, including intraocular engrafted tumour. The presence of doxorubicin was demonstrated in xenograft containing mouse eyes as well as in tumours of a comparable rabbit model. Distribution in extraocular tissues was consistent with previously published data. It is concluded that failure of response to doxorubicin in the xenograft model is not explained by lack of tumour penetration by the drug.

Animals↗
PubMedDate not supplied

Reduced aminolevulinic dehydrase activity with increased blood porphyrins in experimental chronic renal failure.

In the absence of anemia, rats with nephrectomy-induced renal failure displayed a reduced activity of erythrocyte aminolevulinate dehydrase, increased blood porphyrin levels, and a plasma capacity to inhibit the activity of the erythrocyte aminolevulinate dehydrase in vitro. Even though it did increase hemoglobin and hematocrit levels, treatment with erythropoietin had no effect on the derangements of porphyrin metabolism. No abnormalities of the heme pathway were observed in liver tissue. Experimental chronic renal failure reproduced the same abnormalities of porphyrin metabolism usually detected in patients with end-stage renal disease.

5-Aminolevulinate Synthetase↗