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Biomedical subjects

A Barrillon

Publications and source records attributed to A Barrillon.

90 records · Page 5Linked to original sources
PubMedDate not supplied

[Mexiletine therapy of ventricular extrasystoles in the acute phase of myocardial infarction].

25 patients with recent myocardial infarction and ventricular extrasystole occurring either frequently or in bursts were treated by intravenous and then oral mexiletine. Side-effects occurred during the loading dose in 6 patients, then disappeared without sequel, even while treatment was continued in 2 of these patients, or after it was stopped in the remaining 4 (on account of the severity of the side-effects). Rhythm disorders disappeared under mexiletine in 14 patients as soon as the loading dose was administered; its effectiveness was maintained during intravenous perfusion and after the switch to oral administration. Failure occurred in cases of extensive infarction and/or cardiac insufficiency. Mortality, which was zero in those cases in which mexiletine was effective, reached 45% in the failure group. In cases in which mexiletine proved a failure, lidocaine was also ineffective. In one case in which mexiletine was effective, but was stopped because of side-effects, lidocaine proved ineffective. The efficacy of mexiletine is therefore at least equal to that of lidocaine and is maintained after the switch to oral administration.

Adult↗
PubMedDate not supplied

[Evaluation of the sinoauricular conduction time: comparison of the recording of the sinus potential and Narula's method].

The sino-atrial conduction time, measured by Narula's method (SACTN) is compared to the direct sino-atrial conduction time measured by recording the sinus potential (SACTD) in 55 patients, 20 with normal sinus function and 35 with sinus dysfunction. In the absence of sinus dysfunction, SACTN and SACTD are not significantly different and a significant but mediocre correlation (r = 0.57) is observed between the two parameters. Major discordances between the two methods are seen in 4 patients. In cases with sinus dysfunction, there was no correlation between SACTD and SACTN; SACTN is close to SACTD in 12 patients, but much shorter in 11 patients and much longer in 10 patients. These discordances raise the problem of the penetration of the sinus node by the extrastimulus in Narula's method. This method does not seem capable of giving a reliable evaluation of the duration of sino-atrial conduction.

Adolescent↗