[Consensus SOCESP-SBC on nuclear medicine].
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Biomedical subjects
Publications and source records attributed to A Barroso.
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Nineteen children, who had been admitted to the Pediatric Hospital of Coimbra with severe meningococcal infection with DIC, were submitted to clinical and radiological examination, an average of 4.2 years after hospitalization, in order to demonstrate late skeletal lesions. Patellar dystrophy, to our knowledge previously unreported, was found in 4 children, all of whom had overlying cutaneous scarring.
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During a period of twelve years--January 1983 to December 1994, 371 children suspected of foreign body inhalation were admitted in Hospital Pediatric of Coimbra. The diagnosis was confirmed in 200 of them (54%), and this group was analysed. The incidence has increased until 1989 and stabilized in the last 5 years with a median of 18 cases/year. Two third of the children were boys and 84% were under three years old. A history of choking was obtained in 87% of the patients but only 39% of the cases had an early diagnosis (within 24 hours). The most frequent clinical findings were abnormal auscultation, sternal retraction, cough, wheezing and fever. Sixty percent of them were asymptomatic. The chest radiology findings were air trapping in 45%, consolidation in 21% and in 17% there were no abnormalities. Radiopaque foreign bodies were found in 9%. Organic bodies were the most frequent (74%) and among these, peanuts, lupines and beans. Food aspiration in one case took to cardiorespiratory arrest and in another with a late diagnosis bronchial stenosis needed a surgical treatment. Complications of foreign bodies extraction had no consequences.
The recent availability of a genetic analysis for the diagnosis of Huntington's disease (HD) allows now for a careful study of presymptomatic stages of the disease. The aim of this study was to see if subtle cognitive deficits could be elicited on formal neuropsychological testing in asymptomatic HD carriers. Thirty-six individuals at risk for HD, applying for genetic assessment, were studied with a cognitive protocol covering attention, memory, visuospatial and prefrontal functions. Gene IT15 analysis revealed an abnormal expansion of (CAG) trinucleotide repeats in 18 subjects, being normal in the remaining 18. The comparison of the neuropsychological performance between both groups did not show significant differences in any of the cognitive domains. These data support that there is no premorbid cognitive impairment in HD, at least recognizable with the current measures of assessment.