PubMed Health⌕ Search

Biomedical subjects

A Bekier

Publications and source records attributed to A Bekier.

12 recordsLinked to original sources
PubMed1991

Evaluation of a multicentre study with Iomazenil--a benzodiazepine receptor ligand.

After showing in an earlier publication that Iomazenil is a potent benzodiazepine receptor antagonist, the substance has been distributed to 11 clinical centres in Europe for further tests. The protocol asked for volunteers, epileptic cases and patients with Alzheimer's disease. Prior to the Iomazenil examination, flow images by perfusamine or HMPAO were required, and as comparative methods EEG, computed tomography (CT) and magnetic resonance imaging (MRI) were performed. The results allowed first the determination of the normal distribution of the benzodiazepine receptors in the human brain. The highest uptake was found in medial occipital cortex. Second, the evaluation of the epileptic cases shows a 100% positive prediction value for Iomazenil compared to 92% for flow images. Negative prediction values were calculated as 81% for Iomazenil and 54% for flow images. Furthermore, one group reported the successful diagnosis of Alzheimer's disease at an early stage. The visual image examination was tentatively compared to a more objective semiquantitative one based on quotients of corresponding left/right regions of interest. This semiquantitative method has not proved successful yet, but the problems have been identified. A more precise protocol for further studies is therefore proposed.

Adult↗
PubMed1979

Polymyositis, myasthenic syndrome and thymoma in a patient with defective cell-mediated immunity.

We studied a 57-year old woman with severe myasthenic syndrome predominantly proximal. There was no therapeutic effect using cholinesterase inhibitors. Clinical findings, electromyography, whole body scanning and biopsy revealed polymyositis. Thirteen years before the patient was operated of a benign thymoma. The history of the patient showed numerous life threatening episodes of viral and fungal infections. Autoimmune anemia was diagnosed. Investigations of the immune system in vivo and in vitro revealed severe qualitative and quantitative defects in the lymphocyte population spontaneously forming rosettes with sheep red blood cells (SRBC). Thymoma, autoimmune disorder, such as polymyositis and myasthenia gravis, unspecifically elevated antibody titers, multiple severe viral and fungal infections and the defect of the cell-mediated immunity suggest a T-lymphocyte effector- and regulatory dysfunction in this patient.

Autoimmune Diseases↗
PubMed1977

[Difficulties in the differential diagnosis of a non-traumatic, active myositis ossificans during pregnancy (author's transl)].

A 28 year old patient complained of sensory disturbances and pain in the right upper arm during pregnancy. During the 32nd week of her pregnancy, a large painful mass developed in the flexor muscles which, radiographically, showed some calcification. A diagnosis of a parosseous sarcoma was made; biopsy, however, indicated a diagnosis of non-traumatic myositis ossificans. Since the histological appearances of active myositis may be vary difficult to distinguish from a juxtacortical sarcoma, a right brachial angiogram and scintiscan were obtained. The angiographic and scintigraphic findings were erroneously considered to suggest malignancy. Following delivery, the tumour was removed. Futher histology confirmed the diagnosis of localised, non-traumatic myositis ossificans. The value of radiology, biopsy, angiography and scintigraphy are discussed with reference to our experience.

Adult↗
PubMed1976

[Asymmetric brain perfusion in the aged?].

Between 1971 and 1975 we performed 1580 dynamic perfusion studies in 1411 patients. The patients were admitted to the nuclear medicine department for brain scanning from the medical, neurological and neurosurgical departments as well as directly by private family physicians. For dynamic brain studies we used the scintillation camera (Searle Radiographics) and a bolus of 99mTc-pertechnetate intravenously injected. The polaroid frames were exposed at 4 second intervals The results of the dynamic brain study were divided into five categories: normal, moderately diminished perfusion of one hemisphere, severe perfusion defect of one hemisphere, focal or multifocal hypervascular areas ("hot areas") and stenosis or occlusion of the carotid artery. In 1009 cases we found a normal perfusion of the tracer material without any side difference between the brain hemispheres. In 68 patients with motoric hemisyndrome of the right side and in 89 patients with hemisyndrome of the left side we were able to demonstrate a diminished perfusion of the contralateral hemisphere. In 65 patients with confirmed primary or metastatic brain tumors we observed a perfusion deficiency in 39 cases and focal "hot" areas in 26 cases. In 24 epileptic patients we found asymmetrical perfusion of the brain. In 109 patients without any neurological signs or symptoms we registered a "false positive" dynamic perfusion study with an asymmetrical initial transition of the injected tracer material. The left hemisphere showed a diminished perfusion in 86 cases, the right in 23 cases. The asymmetrical brain perfusion was not observed in patients under the age of twenty years. The incidence of "false positive" dynamic brain studies was found to be dependent on the age of the investigeted patients with a maximum of asymmetrical brain perfusion scans in the age group between 61 and 70 years. At present time we are not able to explain the reason of the "false positive" results. Because of this reason the investigation will be continued together with the neurologists and radiologists to find out a possible correlation between our study, the EEG-curves and results of the morphological brain investigations such as pneumoencephalography or ACT-scans.

Adolescent↗
PubMed1976

[The 57Co-excretion and absorption test in the diagnosis of iron deficiency anemia].

1971 Sorbie et al. described a simple 57Co-excretion test (16) as an aid in the diagnosis of iron deficiency anemia. The authors found that renal excretion of a tracer dosis of 0,5 muCi 57CoCl2 was significantly elevated in patients with iron deficiency anemia (31% of the administered dose in 24 hours' urine) as compared with the controls (18%). Between 1972-1974 we performed the 57Co-excretion test in 29 patients with different kind of anemia and in 10 healthy volunteers. The test was modified by measurement of the serum activity 1, 2, 3, 7, 11 and 24 hours after the oral administration of the test dosis. In all anemias as well as in the control group we found the maximum of serum activity three hours after the oral administration of the tracer. The three hours serum activity was elevated only in patients with iron deficiency anemia (5,53%/1 serum) as compared with the control group (1,92%/1) and renal, tumor and infectious anemia (1,20%/1). p less than 0,001. The 57Co excretion was moderately elevated in most of the patients with iron dificiency anemia (average 31,5% 57Co-activity in 24 hours' urine) in comparison to the healthy controls (average 25,30%). Contrary to the results obtained by Sorbie et al. we found a wide range of fluctuation of the Co-excretion test in each group of patients with a poor statistical significance of p greater than 0,005.

Adolescent↗
PubMed1975

[The place of isotope scanning in the diagnosis of pancreatic diseases (author's transl)].

259 isotope scans of the pancreas, done between 1966 and 1973, were analysed. In 62 cases the results of operation or necropsy findings were also available. In 43 of these 62 patients the scans could be diagnostically evaluated, the others being "negative". Among the 43, agreement with operative or necroptic findings existed in 35. All the malignant pancreatic tumours diagnosed by scanning were no longer operable. The place of isotope scanning is seen in general pancreatic diagnosis, especially on careful combination with clinical, special radiological and biochemical studies.

Adult↗
PubMed1975

[Detection of thyreogenic osteopathy with the aid of the modern photon absorption technic].

163 male and female patients with confirmed metabolic status of the thyroid have been investigated with the aid of the 125-J photon absorption technique ("Bone Analyzer"). In the normothyroid group pathologically low values were found in 14.6 percent of cases. Findings which fell below a standard deviation of the normal range were regarded as pathologic. In 42 male and female patients with confirmed thyroid hyperfunction and decompensated autonomous adenomas, mineral content measurements in the radius revealed pathological values in 28.5 percent.

Adolescent↗
PubMed1975

[The radionuclide hepato-angiography in the clinical diagnosis (author's transl)].

In 156 patients the dynamic liver perfusion study with 99mTc-sulfur colloid and the scintillation camera was performed. Out of the 81 cases with confirmed diagnosis, the rapid sequential liver study was only in one case to provide an additional information of clinical importance, which could not be demonstrated by static liver imaging. Except for 2 patients with carcinoid metastases of the liver and 3 cases of acute hepatitis, we did not find any significant difference in the activity appearance in the liver between normal subjects and patients with liver metastases and diffuse liver diseases.

Adolescent↗
PubMed1975

Displacement of anterior cerebral vessels in cerebral dynamic study in cases of chronic subdural hematomas.

About 75-80% chronic subdural hematomas give positive results in a brain scan. The typical scintigraphic finding of chronic subdural hematoma is a diffuse widening and increase of the peripheral activity on the anterior view. In the flow studies subdural hematomas lead occasionally to peripheral activity defects. In two cases of chronic subdural hematoma without typical patterns in a perfusion study as well as in static images, we found a displacement of the anterior cerebral vessels as an indircet sign of space occupation.

Astrocytoma↗
PubMed1975

[A proposal to improve radioactive waste disposal following metabolic radio-iodine therapy].

After metabolic radio-iodine treatments of carcinomas of the thyroid, increased activities of I 131 are secreted from the patient's body by the renal route. The highly radioactive urine represents a serious danger of contamination for the nursing staff and third persons. The ideal conditions for the isolation of treated patients in a department disposing of a sewage disposal system of its own are not fulfilled at our hospital. Collection of radioactive urine of the patients for the purpose of annihilating radioactivity over several half-lifes of I 131 is extremely intricate. For this reason, we developed a filter system by means of which we were able to free the radioactive urine of the first five female patients treated from more than 99% of radioactivity. The contaminated locked filter patterns can be stored as "closed radio-sources" essentially more securely and space saving. The advantages of this system and their practical possibilities of use are discussed.

Female↗