Ocular calcifications in von Hippel-Lindau disease.
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Biomedical subjects
Publications and source records attributed to A Beltramello.
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A series of 57 patients harbouring a total of 63 haemangioblastomas of the posterior fossa is reviewed. Some clinical data are pointed out and the findings of vertebral angiography and computed tomography scanning performed in 61 and 38 lesions, respectively, are examined. The results obtained in the last 38 cases, undergoing both examinations, are compared, and some notes on differential diagnosis with other expansive lesions of the posterior fossa are given.
A case of a large middle fossa arachnoid cyst that spontaneously disappeared is reported. The possible mechanisms involved in the "natural cure" of this lesion and the indications for surgical versus conservative treatment of middle fossa arachnoid cysts are discussed.
Head injuries are a common cause of death and permanent disability, particularly in the first decades of life. The high mortality and morbidity associated with head trauma is due mostly to the severity of the injury itself but also in part to the possible events that could aggravate the primary brain damage. This also occurs in patients with an initially mild head trauma. This article reviews imaging procedures, complications of head trauma, and the order of diagnostic evaluation.
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The case of a 74 yr. old male affected by a mixed cell choroidal melanoma is reported. Ophthalmoscopic examination suggested a choroidal melanoma; this diagnosis was confirmed by fluorescein angiography, ultrasonography and CT-scan. In particular, contact ultrasonography (A-mode and B-mode), following topographic, kinetic and quantitative diagnostic criteria, revealed a solid lesion with the typical features of a choroidal melanoma. Ultrasonography by differential selective echographic technique revealed that the lesion consisted of two components with different acoustic features : the first characterized by a 41 dB reflectivity (peripheral and superior portions), the second by a 23 dB reflectivity (central and inferior portions). Attenuation values were 1.2 dB/mm and 0.7 dB/mm, respectively. CT-scan did not show any significant change in density within the mass. Histopathologic evaluation confirmed a clear-cut edge between the epitheloid and the spindle-cell components. The more reflecting lesion (23 dB), located in the central-inferior portion of the lesion, was histologically less dense and was due to the epitheloid component. The superiorally located more attenuating lesion (1.2 dB/mm) was histologically more dense and due to the spindle-cell component.
Five cases of posttraumatic carotid-cavernous fistula are reported. The fistulas were occluded by intravascular detachable balloons, as described by Serbinenko and later modified by Debrun. The good results obtained in three of these patients illustrate the value of this procedure, as it allows a direct obliteration of the fistula with preservation of the internal carotid blood flow.
The Foix-Chavany syndrome is a neurological entity characterized by linguo-bucco-facial apraxia almost always caused by disturbed cerebral circulation. Three typical cases of this syndrome are described and the role of the CT scan to obtain a definite diagnosis is emphasized.
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The CAT shows the site, extension and evolution of cerebral ischemic lesions, and implies no risk or pain for the patient. Cerebral ischemic lesions appear as dark, hypodense areas on the brain section planes and are well differentiated from the white hyperdense areas of hemorrhagic lesions. In the territory of the middle cerebral artery the symptomatology is well related to the extension of the lesions, but not to their site when they are 'limited'. At present the CAT is essential for the treatment of cerebral ischemic lesions.
Diagnosis of Alzheimer's disease is made on clinical grounds, and the availability of a simple and sensitive quantitative index of the disease might aid in the routine diagnosis. The aim of this study was to assess whether linear measures of brain atrophy as detected by magnetic resonance imaging can be helpful in the differentiation of mild to moderate Alzheimer's disease from nondemented elderly. Measures of global (bifrontal index and interuncal distance) and hippocampal (minimum thickness of the medial temporal lobe, hippocampal height, width of the choroid fissure, and width of the temporal horn) atrophy were taken from 26 cases and 21 controls. Measures of hippocampal atrophy were the most sensitive in the differentiation of cases from controls, and among them width of the temporal horn yielded the highest sensitivity, predicting the disease in 73% of cases with 95% specificity. A compound measure comprising width of the temporal horn, width of the choroid fissure, and hippocampal height increased sensitivity to 85%. These results suggest that selected simple indices of hippocampal atrophy might be useful in the diagnosis of Alzheimer's disease.
The technique with a wing microcatheter system and the pathologic aspects of 11 cerebral arteriovenous malformations (AVMs) surgically resected after embolization with polylene threads are reported. Embolization was performed once in eight patients and twice in three patients. Resected AVMs were submitted both to routine hematoxylineosin examination and to immunohistochemical workup in order to detect the type of immunologic response to thread emboli. In nine cases, 50% or more of the nidus was obliterated by the embolization. After embolization two patients developed reversible neurologic deficits. Pathologic specimens of resected AVMs demonstrated no vascular necrosis; however, a moderate inflammatory response could be seen, characterized by the presence of both mononuclear cells and foreign-body giant cells, associated with the absence of polymorphonuclear infiltrates. A granulomatous fibrotic process was identified that was present from the first month after embolization. Immunohistochemistry indicated that the immunologic response to thread emboli was cell-mediated, not humoral. Embolization with the wing microcatheter with the use of polylene threads proved to be a safe and efficient system of embolization, as a preoperative procedure. Polylene threads are a nontoxic and biocompatible material that can be used as an embolic agent for brain AVMs.
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The authors report the results of a large series of patients which underwent surgical treatment for cervical spondylotic myelopathy. In this retrospective study clinical findings before surgery are compared with results at the follow-up after two years; their significance as prognostic factors is investigated. Marked spasticity, prevalence of unilateral motor signs, presence of Brown-Sequard syndrome and of Lhermitte sign resulted valuable criteria in predicting outcome after surgery.
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The role played by neuroradiologic examinations in the diagnosis of neoformations of the pineal region is considered. Results of reports of literature are compared with the personal experience (40 patients) to draw possible significant conclusions for the diagnosis of the oncological type. First, intrinsic pineal lesions should be separated from those of adjacent structures. Reliable discriminating parameters useful in the differential diagnosis are represented by sex and age. Diagnosis based on biochemistry with markers was shown not to be univocal. A further separation can be based on CT and MRI findings. In particular, teratomas appear as solid tumors with calcification and fat. The latter is depicted on MRI even if minimal. To the contrary, germinomas do not contain fat and are markedly enhancing. Microcysts seem to be more common in tumors originating from parenchymal pineal cells. A reliable differential diagnosis is however possible only for small-sized lesions where identification of the anatomical structure of origin is easier.
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