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Biomedical subjects

A Benke

Publications and source records attributed to A Benke.

At least 19 recordsLinked to original sources
PubMed1992

High incidence of asymptomatic urogenital infection in patients with uveitis anterior.

Acute anterior uveitis (AAU) may be associated with systemic infectious or inflammatory disease. We examined 92 patients with the first attack of acute anterior uveitis; all patients were free of any extraocular symptoms. A thorough clinical examination did not reveal any systemic underlying disease. In the course of microbiological examination, however, a high incidence of asymptomatic infection of the urethra and/or cervix with ureaplasma urealyticum, chlamydia trachomatis and mycoplasma hominis was found. Infections with ureaplasma were significantly more frequent in patients with AAU when compared with a sex- and age-matched control group. There was no statistically valid association of these infections with the HLA-B27 phenotype in the patients. The higher rate of urogenital infections in patients with AAU may reflect a higher rate of sexual promiscuity. Transmission of infectious agents seems to be one possible factor in the pathogenesis of AAU.

Acute Disease↗
PubMed1986

Effect of infusion of salmon calcitonin on the secretion of somatostatin and gastrin in man.

In vitro and animal studies have pointed out complex interrelations between gastrointestinal hormones and calcitonin. To analyse the acute effects of calcitonin in more detail, patients undergoing surgery were infused intravenously with synthetic salmon calcitonin, a potent analog of the human hormone. Samples were taken after 0, 30 and 60 minutes from the hepatic, portal and a peripheral vein. Somatostatin and gastrin were determined by radioimmunoassay. The mean basal levels of somatostatin in peripheral and hepatic venous plasma (14.2 and 15.6 pg/ml) were significantly lower than in portal plasma (45.6 pg/ml), indicating effective removal by the liver. After infusion of calcitonin there was a general rise in somatostatin levels and an increase in the gradient between hepatic and portal blood. Basal gastrin levels were highest in the portal vein when compared intraindividually. The differences disappeared after calcitonin infusion with a concomitant systemic reduction of gastrin levels. Thus, calcitonin is able to stimulate the secretion of somatostatin from the gastrointestinal tract and does reduce gastrin secretion, possibly via the stimulation of somatostatin secretion.

Adult↗
PubMed1983

[Observation of the radiologic course in long-term artificial respiration].

In a retrospective study, 108 patients were followed up who had to undergo artificial respiration treatment because of respiratory insufficiency. X-ray diagnosis showed a shock lung in all the patients. X-ray morphology correlates with the pathologicoanatomical substrate which develops progressively in phases. 24 patients (22%) could be saved, which is a remarkable success in view of the usually fatal prognosis. It was encouraging to find that follow-up examinations of the surviving patients did not reveal any detectable sequels of the "shock lung"; likewise, no unfavourable effects of the respiratory therapy were noticed.

Adult↗
PubMed1979

[The solubilizer of diazepam (valium)--its action on respiration (author's transl)].

Investigations carried out in volunteers showed that when compared with physiological saline the solubilizer of diazepam caused hyperventilation. Among the constituents of the solubilizer propylene glycol and ethyl alcohol have to be excluded, likely benzyl alcohol was due to the respiratory response. Benzyl alcohol has local anesthetic properties and its action on respiration has never been examined up to now. Therefore a further study was performed to compare ampoule solutions of diazepam with or without benzyl alcohol in the solubilizer used. The solutions were given intravenously, the dose of diazepam was 0.35 mg/kg, that of benzyl alcohol 1.1 mg/kg respectively. The measurements showed that solutions containing benzyl alcohol produced a statistical significant increase of respiratory rate and of minute volume. In case of intravenous administration of Valium using ampoule solutions diazepam and in addition a second active substance are applicated. The latter defined as benzyl alcohol has stimulating effects on respiration.

Adult↗
PubMed1979

[Anaesthesia for peripheral angiographies (author's transl)].

The anaesthetic requirements for peripheral angiographies in geriatric or poor risk patients are temporary sedation, analgesia and sufficient immobilisation. Neither general anaesthesia using muscle relaxants and assisted ventilation nor regional methods warrant satisfactory results in all cases, especially if multiple arteriographies are to be performed at the same session. Therefore a few new anaesthetic techniques were studied, having combined benzodiazepines with ultrashort acting intravenous narcotics. Premedication with Pethidin 1mg/kg, the administration of Flunitrazepam 0,017 mg/kg with regard to sedative, analgesic and relaxant effects and Methohexital 0.67 mg/kg as anaesthetic given prior to injection of contrast medium would seem more useful than other techniques.

Aged↗
PubMed1976

[Etiology of shock lung: case report (author's transl)].

In a woman, 29, two times resection and anastomosis of the small intestine because of extended infarction was performed. Following peritonitis and septic shock a progressive respiratory insufficiency developed and patient died 48 hours later despite intensive ventilatory treatment. Autopsy findings were manifold vascular damage (aorta) and thromboembolisms in mesenteric vessels and iliac veins too. Patient received oral contraceptives over several years, changed the preparation previously and contraceptive therapy was continued with another one. Thromboembolic complications may understood as undesirable side effects of the contraceptives. By microscopy of lung thrombosis in capillaries was seen and in small arteries too, as embolism carried by the blood stream. In pathogenesis of shock lung macrothrombosis as an aetiologic factor is to be discussed.

Adult↗
PubMed1976

[The radiological diagnosis of shock lung (author's transl)].

So-called "shock lung" has typical pathological findings; radiologically it is characterised at first by interstitial, late by alveolar pulmonary oedema. This has been shown by a number of case reports. In addition to shock, however, certain intoxications and all forms of left heart failure produce the radiological changes of pulmonary oedema. Transient hyperhydration of the lungs following infusion therapy causes signs of pulmonary oedema which disappear as soon as the fluid balance becomes normal. The radiographic findings of pulmonary oedema correlate well with the intensity and extent of the pathological changes. The radiologist is therefore in a position to evaluate the severity of the shock lung; this is a valuable addition to the clinical findings and the results of physiological tests and blood gas analysis. It has to be emphasised that the radiological changes appear at an early stage, in any case much sooner than the clinical features. Radiological findings may be present without abnormalities on oscultation or percussion. Radiographs of the lungs are therefore indicated in all patients who may be subject to shock lung, particularly if they suffer from undiagnosed hyperventilation.

Adult↗
PubMed1975

[The effects of flunitrazepam (rohypnol) on respiration (author's transl)].

The effects of flunitrazepam (0.03 mg/kg administered intravenously over a two-minute period) was investigated in 11 healthy volunteers with normal pulmonary function. Spirometer tracings were recorded continuously by the Siregnost FD 40 and blood gas measurements were performed by the Harnoncourt AVL gas analyzer. Flunitrazepam produced a characteristic cyclical hypoventilation/hyperventilation pattern lasting 15 min., followed by quiet sleeping rhythms. The duration of action was 20 min. There was a significant fall in PCO2, whilst the CO2 tension showed a significant rise. Changes in pH were in accordance with respiratory acidosis. Apnoea did not occur after the administration of flunitrazepam.

Anti-Anxiety Agents↗