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Biomedical subjects

A Benn

Publications and source records attributed to A Benn.

9 recordsLinked to original sources
PubMed1992

ST segment alternans during coronary angioplasty.

Four patients with severe proximal or mid-LAD stenosis were noted to have ST alternans during balloon angioplasty. Neither mechanical alternans nor increased ventricular ectopy were noted. In contrast to prior descriptions in animals or patients with variant angina, ST alternans did not occur following a premature ventricular contraction. Frequent use of calcium channel blockers during PTCA may interfere with the mechanism leading to electrical alternans and its consequences as seen in animal studies, accounting for the low frequency with which this phenomenon is noted during PTCA.

Adult↗
PubMed1991

Primary structure and expression of a chicken cDNA encoding a protein with zinc-finger motifs.

We report the cloning and sequence analysis of a chicken nearly full-length cDNA clone, cKr1, encoding a protein of 509 amino acids which contains ten 2Cys + 2His-type zinc-finger motifs arranged in two separate sets of five zinc fingers each. The cKr1 transcripts are detected in organs of the adult chicken, predominantly in the brain and lung. At day 4 of embryonic development strong cKr1 hybridization signals are found in the brain and neural tube, in the mesonephros and in the gut, respectively.

Alpharetrovirus↗
PubMed1986

Clinical correlates do not predict PaO2 response after tolazoline administration in hypoxic newborns.

In an attempt to determine which hypoxic newborns might benefit from administration of tolazoline hydrochloride (Tz), we identified all neonates known to have received Tz at four Chicago area perinatal centers over a 4-yr period. For each of 41 infants, five statistical analyses were used to correlate 31 clinical and ventilatory variables with PaO2 values before and after Tz administration. Fourteen neonates responded to Tz infusion with more than a two-fold increase in PaO2. None of 31 clinical variables successfully predicted a positive Tz response in these infants, and a positive response (increased PaO2) was not associated with increased likelihood of survival. BP fell after Tz in 72% of patients, while heart rate rose after Tz treatment in 66% of cases. These data suggest a need to re-evaluate the administration of Tz to hypoxic newborn infants.

Blood Pressure↗
PubMed1983

A fetus with a chromosome 13 ring and placenta with chromosome 13 rod/ring mosaicism.

A fetus was identified by prenatal cytogenetic diagnosis as having a karyotype 46,XY,r(13) (p11q13). Termination of the pregnancy yielded a severely malformed fetus. Fetal abnormalities included anencephaly, imperforate anus and urethral meatus, severe talipes, syndactyly, cardiac defects and other anomalies. Confirmatory studies on cultured placental villi cells indicated a second cell line, 46,XY, -13,+13qter leads to cen::13q13 leads to qter. This cell line was not detectable in cells derived from the fetus despite extensive studies. It seems likely that the two cell lines arose simultaneously with selection favouring the 46,XY,r(13) line. How the chromosome rearrangements may have arisen is discussed. We are unaware of other cases where a cell line identifiable by a chromosome abnormality appeared to be confined to placental tissue. However, studies on placental tissue may be helpful in understanding the origin of other unbalanced de novo rearrangements.

Abnormalities, Multiple↗
PubMed1971

Effect of intraluminal pH on the absorption of pteroylmonoglutamic acid.

The administration of pteroylmonoglutamic acid and either sodium bicarbonate or phenytoin sodium in normal subjects and epileptics results in lower serum levels of folic acid than when administered alone. Bicarbonate administration was shown to produce a more alkaline pH in the jejunum, while an alkaline pH was found in some epileptics on phenytoin therapy. The physicochemical mechanisms whereby folic acid absorption is reduced in an alkaline medium are considered, and the implications on folate absorption in other disease states are discussed. The mechanism by which phenytoin sodium alters the intrajejunal milieu is obscure.

Bicarbonates↗