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Biomedical subjects

A Besset

Publications and source records attributed to A Besset.

69 records · Page 4Linked to original sources
PubMed1978

[Effect of piribedil on nocturnal sleep (author's transl)].

Piribedil, a dopamine agonist, was administered to 5 normal male subjects for two weeks. During the first two nights there was a reduction of about 17 p. 100 in paradoxical sleep (PS) and an increase of about 13 p. 100 in slow sleep II. There was a 15 p. 100 increase in PS during the third night. This increase is maintained for 8 nights in 3 subjects and 13 nights in 2 subjects. Other sleep parameters were not altered. Piribedil appears to give the impression of satisfactory sleep by reducing the subjective period before falling asleep. Piribedil also diminishes the remembrance of dreams.

Adult↗
PubMed1976

[Secretion of gonadotropins during sleep. Changes during secondary amenorrheas].

4 females with secondary amenorrheas underwent sleep polygraphic recordings together with blood samples for measurements of LH, FSH and GH, 3 normal females served as controls. Among normal subjects LH and FSH secretion showed a pulsating pattern around the time of ovulation, appearing as secretory episodes throughout the night, without any relationship with sleep stages. In amenorrheas, 3 types of abnormalities could be identified: the first was a lack of secretory episodes of LH and FSH associated with an abnormal pattern of GH (9 subjects). The second was an hypersecretion of LH and a decrease of FSH secretion together with a normal secretion of GH in 4 subjects with a Stein-Leventhal syndrome. The last one was an hypersecretion of LH and FSH together with a normal pattern of GH in a subject with an early menopause. These results are discussed according to the present data on the part of neurotransmission in the regulation of ovulation and the 2 types of sleep. Furthermore secretory abnormalities of LH and FSH together with a disconnection between GH secretion and the stages of sleep lead to question the possibility of interrelationships in the secretory mechanisms of these different hormones.

Adolescent↗
PubMed1975

[Secretions of GH, FSH and LH during sleep of the normal child and the child with retarded growth].

In normal children the major GH release begins during NREM sleep of first cycle. At puberty secretion of gonadotropins is enhanced and secretion of LH occurs with the same periodicity as the sleep cycles. Two groups of dwarfish are seen: the first lacks both GH secretion during sleep and the increase of gonadotropins at puberty. The second group exhibits GH, LH and FSH secretion patterns similar to normal children. Study of secretion patterns of GH, FSH and LH during sleep in children can document the degree of maturation of the hypothalamic pituitary hormonal system.

Adolescent↗
PubMedDate not supplied

[Insomnia in bismuth encephalopathy (author's transl)].

Myoclonic encephatopathy caused by the insoluble salts of bismuth may be accompanied by a state of total insomnia. This insomnia has been confirmed by polygraphic recordings in 3 subjects. The recovery of sleep has a stereotyped course, with a step-wise reappearance over time of sucessive stages of NREM sleeps tarting with stage age I, and parallel re-establishment of REM sleep. Return to normal sleep lags behind clinical recovery. A pharmacological analysis with the phobenecid test was attempted in 2 of the 3 subjects. The results were the same in both as regards renewal of lumbar 5 HIAA, which paradoxically is not changed much; as regards the rate of lumbar HVA renewal, the results were quite different.

Adult↗
PubMedDate not supplied

[Sleep organization by subjects in chronical post-traumatic inconscience (author's transl)].

Nine subjects who underwent a severe head traumatism with a brainstem dysfunction at the acute stage, were polygraphically recorded at the chronic stage under strict conditions of drug withdrawal and light-dark periods. Two groups of subjects were identified. The first one (5 subjects) showed normal NREM sleep and REM sleep morphologic patterns as well as a partly preserved architecture of sleep. The synchronisation of sleep with dark periods was lost in 4 out of 5 cases. In the second (4 subjects) NREM sleep morphologic patterns were lost and REM sleep was either uncertain or absent in 3 subjects. The synchronisation of sleep with dark periods was lost in 3 out of 4 cases. The morphologic alterations of sleep are connected with different types of encephalic lesions whereas the anomalies of the architecture of sleep and of its synchronisation with dark periods are referred to the numerous endogennous and exogenous stimuli undergone by these subjects. At the chronic stage of post-traumatic comas a 24-hour polygraphic recording supplies no definite information with regards to the prognosis.

Adult↗
PubMedDate not supplied

Circadian patterns of growth hormone and cortisol secretions in narcoleptic patients.

Narcolepsy, a disorder which is clinically characterized by recurring episodes of sleep during the day, frequently associated with nocturnal disrupted sleep and polygraphically by sleep onset REM periods, has been studied in regard to the relationships between GH, cortisol secretion and sleep. Ten narcoleptics were polygraphically recorded during 24 h after one night's adaptation. Blood samples were taken every 20 min for GH and cortisol immuno-assays. Three narcoleptics were recorded twice 2 months later and 2 normal subjects served as controls. The following results were obtained: GH secretory pattern was different in narcoleptics and controls; two groups were identified: the first one showed a very low basal GH secretion with rare and small secretory peaks not clearly linked with sleep. One subject of this group recorded twice showed a similar pattern. The second group exhibited a higher basal secretion with many peaks without any well-defined relationship to sleep stages. The pattern was again consistent in two recordings of 2 subjects in this group. Furthermore GH secretion rose significantly (p less than 0.01) between 2100 and 0000 with no apparent relationship to sleep stages. The cortisol secretory pattern showed a significant rise (p less than 0.01) between 0400 and 1000 and was not different in narcoleptics and controls. In narcolepsy the monophasic sleep-wakefulness cycle is disrupted. The GH secretion pattern is modified whereas the circadian pattern of cortisol secretion is normal and independent of the sleep-wakefulness cycle of the narcoleptic patient.

Adult↗