Biomedical subjects

A Beyer

Publications and source records attributed to A Beyer.

75 records · Page 5Linked to original sources

PubMedDate not supplied

[Fundamental aspects of osteoinductive activity of bone tissue and potential clinical application].

Osteoinductive polypeptide factors such as the various isoforms of Bone Morphogenetic Protein described are of increasing scientific and clinical interest because of the great progress in this field of skeletal biology recently achieved. In a review some fundamental chemical and biological aspects of bone and its endogenous osteoinductive activity including isolation and assay of osteoinductive factors are described. Through combination of osteoinductive factors with appropriate carrier materials it seems possible to create osteoinductive implant materials and the results of such investigations and some basic aspects of carrier materials are summarized. The perspectives of the possible clinical applications of such composite are presented.

Biocompatible Materials↗

PubMedDate not supplied

Muscle phosphorylase kinase is not a substrate of AMP-activated protein kinase.

AMP-activated protein kinase (AMPK) and cAMP-dependent protein kinase (cAMPK) have been reported to phosphorylate sites on phosphorylase kinase (PhK). Their target residues Ser 1018 and Ser 1020, respectively, are located in the so-called multi-phosphorylation domain in the PhK alpha subunit. In PhK preparations, only one of these serines is phosphorylated, but never both of them. The aim of this study was to determine whether phosphorylation by cAMPK or AMPK would influence subsequent phosphorylation by the other kinase. Surprisingly, employing four different PhK substrates, it could be demonstrated that, in contradiction to previous reports, PhK is not phosphorylated by AMPK.

AMP-Activated Protein Kinases↗

PubMedDate not supplied

[Exposure of the Berlin population to aromatic hydrocarbons and heavy metals within the scope of a study of the health effects of vehicular traffic].

As part of an environmentally oriented study, 800 women from two Berlin boroughs, between 30 and 45 years of age, were examined of their exposure to aromatic hydrocarbons, lead, and cadmium. The aim of this investigation was to determine the actual exposure of a representative population of Berlin to these xenobiotics and to evaluate the influence of other factors on the parameters measured in the blood. The geometric average values obtained in the analysis of the blood of the women included in the study, were 30 micrograms/l (144.9 nmol/l) for lead and 0.34 microgram/l (3.04 nmol/l) for cadmium (those who had never smoked 0.25 microgram/l; smokers 0.69 microgram/l). Compared to the 'eighties, blood lead concentration declined and to date only 1% of our study population had values > 100 micrograms/l. Smoking was confirmed to be a major influence factor. There is also a relation between lead in the blood and the use of alcoholic beverages and the presence of lead pipes in drinking water systems of the houses. The geometric means obtained were 0.41 microgram/l for benzene and 0.73 microgram/l for toluene and therefore higher than previously described in the literature. A statistical connection of benzene in blood to the indoor air concentration or the to the average daily traffic density could not be seen, but there is a relation to smoking habits.

Adult↗