Biomedical subjects
A Bissi
Publications and source records attributed to A Bissi.
[Description and results of a simplified procedure for intraoperative electron radiotherapy].
In San Raffaele Institute a simplified procedure for intraoperative radiotherapy (IORT) was developed. An applicator system of "guide-containers" was used to facilitate the use of IORT (with electron beam) with different treatment fields. Application of this technique was studied; no IORT related complications was observed in phase I and clinical good results are reported.
[Not Available].
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[Adrenalectomy in the treatment of breast cancer in advanced stages].
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[Ileo-ureteroplasty. General principles and prognostic evaluation].
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[Detection of Koch's bacillus in urine by means of filtrating membranes].
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[Contorni's hemometakinetic subclavian vertebral syndrome--report of a case].
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[First bronchoangiographic study of the hemotopic ganglio-- bronchial syndrome].
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[Unusual cause of bilateral paralysis of the anterior tibial muscle].
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[Use of the pacemaker with intravenous electrode in the treatment of atrio-ventricular block].
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[Therapeutic effect of a new antisecretory and antacid medication].
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[Central venous pressure. A modern parameter of shock].
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[Diagnostic cytology on filtering membranes].
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[Study of gastric exfoliative cytology with the aid of "Millipore" filtering membranes].
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[Current knowledge of the nature of the internal renal damage in the so-called "lower nephron syndrome" following various types of shock].
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The role of intraoperative therapy by electron beam and combination of adjuvant chemotherapy and external radiotherapy in carcinoma of the pancreas.
AIMS AND BACKGROUND: In the treatment of pancreatic carcinomas, one modality is intraoperative radiotherapy (IORT). A study was carried out to assess the feasibility of IORT alone or in a multimodality approach with postoperative adjuvant chemotherapy and external radiotherapy and to compare local control and survival of patients. Another objective of this retrospective study was to verify prognostic factors in resected patients treated with IORT. METHODS: From January 1985 through September 1992, 54 adenocarcinomas of the pancreas (unresectable and resected patients) were treated with IORT by electron beam at the San Raffaele Hospital and then analyzed. Comparison was also carried out between IORT-treated resected patients and a non-randomized control group of resected patients treated without IORT in the same period. RESULTS: In unresectable patients treated by laparotomy bypass and IORT, overall median survival was 6 months and 8 months in non-metastatic patients. Relief of severe pain present in 14 patients was observed in 85% within 12 days of IORT. As regards resected patients, the most important finding was that significantly better local control resulted from IORT. In fact, overall, local relapses were 25% in the IORT group and 55.8% in the non-IORT group (control group); instead, survival of the IORT group was not significantly longer than that of the control group. From a statistical analysis of resected patients treated with IORT and performed on prognostic factors on the basis of available data, survival was significantly influenced by tumor pathologic grading and diameter; postoperative adjuvant therapy was not a significant prognosis factor. CONCLUSIONS: IORT has a role in local control of unresectable pancreatic carcinomas and in control of resultant severe pain. In resected patients, IORT is effective in decreasing local recurrences but has little impact on survival. To obtain more satisfactory results, new and more effective adjuvant therapies and better abdominal prophylaxis should be tested.