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Biomedical subjects

A Blömer

Publications and source records attributed to A Blömer.

At least 19 recordsLinked to original sources
PubMed1999

Rat-to-mouse small bowel xenotransplantation: a novel model for studying acute vascular and hyperacute xenograft rejection and xenogenic cell migration.

The present study was undertaken to establish a rat-to-mouse vascularized small bowel xenotransplantation model to study acute vascular and hyperacute xenograft rejection, and xenogenic cell migration. Lewis rat small bowel grafts were transplanted heterotopically to group 1, Balb/c mice, and group 2, Balb/c mice pre-sensitized with a donor spleen cell injection. The grafts were examined by serial pathology and flow cytometry. In group 1, acute vascular rejection was present by the 5th post-operative day (POD). Immunohistology showed a strong endothelial deposition of IgG, IgM and C3, associated with a minimal lymphocytic infiltrate. There was a vigorous cell migration from the recipient to the graft, in which recipient origin cells comprised 80.1+/-6.9% of the graft mesenteric lymph node by POD 3. However, there was almost no cell migration from the graft to the recipient. The intestinal xenografts in the group 2 showed massive hemorrhage, fibrin deposition, vascular congestion and thrombosis 60 min after transplantation. IgG and C3 were present on the endothelium as early as 1 min after reperfusion. The vigorous humorally-mediated vascular damage and rapid elimination of donor cells seen with intestinal xenograft rejection are distinct from the usual picture of allograft rejection. Hyperacute rejection can be induced by recipient pre-sensitization with donor spleen cells. The potential advantages of studying xenotransplantation in this model include: (1) the wide range of immunologic reagents available for mice; (2) the opportunity to study the progression of vascular damage easily by performing serial biopsies in the same animal; and (3) the opportunity to study, in vivo, two-way cellular response by examining cell trafficking in the mesenteric lymph nodes.

Animals↗
PubMed1983

[Surgical treatment of ulcer disease 5 years before and after the introduction of cimetidine].

To determine whether H2-antagonists have changed type and frequency of operations for peptic ulcer, all operations of the one hospital of a city with a population of 80 000 were analysed. The total number of operated patients decreased after cimetidine from 425 to 278 (35%). The ratio of male to female patients was 3:1 in either period. While the decrease in elective operations of uncomplicated ulcer was 51%, operations in patients with ulcer complications (bleeding, perforation, stenosis) decreased by only 9%. The decrease was above average in Billroth I and Billroth II gastrectomy, but the number of patients with selective vagotomy increased 3-fold. The number of operations decreased by 40% for duodenal ulcer and by 20% for gastric ulcer. Of all ulcer complications bleeding decreased by 31%, the number of perforations was unchanged, but the number of patients with stenosis increased by 58%. Overall mortality decreased from 25 in the initial to 20 in the subsequent five year period. Twenty and 19 patients, respectively, died with complicated ulcer disease (12,5% of all operations), mortality was 6 (1,5%) with operations for uncomplicated ulcer.

Cimetidine↗
PubMed1980

The management of amputations of the leg using a new rigid foam plaster for prosthetic fitting.

This paper describes the use of a rigid polyurethane foam to construct a stump socket for immediate or early prosthetic fitting in 15 patients with amputation through the leg. The foam plaster is poured into a prepared cotton sleeve, with a zip incorporated, and rolled out to a layer 4 mm thick. The filled sleeve is put around the stump and the zip closed, moulding the sleeve firmly to the stump. The closed sleeve hardens into a rigid polyurethane shell within 20 min. Aferwards the skeletal prosthetic components are fixed with the same rigid foam. The polyurethane foam socket is quickly and cleanly prepared, only one third of the weight of a plaster of Paris cast and is easily removed by means of the zip, allowing access to the stump.

Aged↗
PubMed1976

[Development and application of a new polyurethane plastics support bandage (author's transl)].

Experiences with a newly developed plastics support bandage on 1007 patients are reported. A polyurethane hard foam composition developed specially for medical purposes was used, which is created by blending the two components A (polyol) and B (isocyanate). The principle of our support bandage lies in the fact that after being mixed in a 1:1 ratio, the two highly viscous components are packed into a cotton stocking having a high transverse elasticity. After being rolled out to the desired thickness, the stocking is wrapped around the extremity which it is to support, where it hardens out into a polyurethane hard foam composition. By reason of the moisture content of the scoured cotton stocking, a 1 to 2 mm thick layer of foam forms in the contact region and renders any further padding unnecessary. Correspondingly, by using a double chamber stocking, circular bandages have been produced which can be removed, by means of incorporated zip and interengaging hook fasteners. Reclining shells, abduction bandages and body corsets can be made in the same way. The physical properties of the support bandage are illustrated: apart from its low weight, the bandage is particularly advantageous by reason of its high strength, insensitivity to water and ideal permeability to X-rays. The support bandages are easily made up and entail negligible cost.

Braces↗