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Biomedical subjects

A Bonaly

Publications and source records attributed to A Bonaly.

4 recordsLinked to original sources

The topology of perceptive functions as a corollary of the theorem of existence in closed spaces.

The capability for a system of perceiving both outer objects and an inner self are two fundamental features of abstract mathematical objects endowed with the properties of topologically closed sets. Such structures exist upon intersection of topological spaces owning different dimensions. Then, the theorem of Jordan-Veblen provides their capability of being observable, while the theorems of Brouwer and of Banach-Caccioppoli provide two kinds of fixed points which account for the properties of so-called right and left brain functions. Fixed points account for the biological 'self', and the system provides theoretical justification for the existence of brain structure/function relationships, including memory, emotion, and respective characteristics of right and left hemispheres. Hence, an abstract topological reasoning based on set properties, provides evidence that the observer's function directly infers from the phenomenon of existence and that it belongs to the same mathematical system as the property of being observable. Order relations are raised from equivalence relations by Poincaré groups, upon mappings on the sets of functions and related homotopic transformations in sequences of intersections. Therefore, time is a construction of abstract brain functions, and a living organism just fills the system with appropriate molecular structures.

Biological Evolution↗

Beware of a new carcinogenic risk: promotion of promoters.

Restricting the evaluation of carcinogenic risk to genotoxicity or mutagenicity tests, as recently recommended by some researchers, is a hazardous operation, since the carcinogenic process involves a complex sequence of events in which no simple, necessary and sufficient condition is known for either the occurrence or non-occurrence of a cancer. None of the available tests exhibit a generalizable meaning, while none of the carcinogenic process phases should be neglected in prediction studies. In particular, ignoring promoter action and progression or proliferation, as well as targets specificity and other points, should lead to an underestimation of the actual risk.

Animals↗

Study of isotonic contrast media in intravenous digital subtraction angiography.

Arterial enhancement obtained with isotonic contrast media in intravenous digital subtraction angiography was studied. Ten dogs were injected with ioxaglate, iopamidol, and ioxitalamate at equal iodine concentration and at concentrations corresponding to plasma osmolality. Three variables were studied: osmolality, injection rate, and iodine dose. Provided their iodine concentration is sufficient, isotonic contrast media appear as efficient as the corresponding hypertonic formulation, at equal iodine dose. Moreover, the use of isotonic ioxaglate allows a lower dose of iodine to be administered without significant reduction in peak arterial value.

Animals↗

[A rapid method: the 100-hue test].

A new and fast method for scoring and assessing the 100-Hue test (Farnsworth-Munsell) is reported. This method allows to simultaneously transcribe graphically the responses of the patient. This method reduces drastically the duration of examination and calculation, without modification of the principle of the 100-Hue Test. The qualitative and graphic validity, the statistical validity are analysed from 103 pathological subjects and 53 normal subjects. The two methods (Farnsworth-Kinnear and fast method) are examined comparatively.

Color Perception Tests↗