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Biomedical subjects

A Bondi

Publications and source records attributed to A Bondi.

13 recordsLinked to original sources
PubMed1990

Primary malignant lymphoma of sciatic nerve. Report of a case.

A 72-year-old man with a 2-year history of motor-sensory neuropathy of the right foot was found to have a lymphoma involving a 50-cm length of the sciatic nerve. This occurred in the absence of any other evidence of disease by detailed clinical staging. The lymphoma was of large follicular center-cell type. The cells strongly expressed a B-cell marker detected by the 4KB5 monoclonal antibody and selectively infiltrated the nerve bundles, dissociating preexisting myelin-producing Schwann cells and axons. This is the second report of similar localization. Primary selective involvement of a nerve is a rare mechanism of peripheral neuropathy in lymphoproliferative disorders, to be added to systemic dissemination of lymphomas and leukemias, direct spread of an adjacent tumor, and immunologically mediated disease.

Aged↗
PubMed1976

The ileum of the sheep as a site of protein digestion.

1. In order to study the ability of the ileum of the sheep to digest and absorb protein, casein or gluten were infused into the intestine of rams through cannulas inserted at distances of 0-05, 7, 9 and 15 m from the pylorus. Amounts of casein or gluten containing 10-20 g nitrogen were infused during 24 h, in animals given a low-N diet. 2. N balance was negative during the preliminary period when no infusion was given; infusion of casein or gluten increased the daily N retention to 5-15 g. 3. Infusion of proteins into the intestine did not induce an increased activity of pancreatic proteases in digesta withdrawn from the lower part of the intestine. 4. The increased N retention after the infusion of proteins into the lower part of the intestine indicates a considerable capacity of this section of the intestine to digest and absorb proteins.

Animals↗
PubMed1976

Nonsterilizing immunity in avian malaria: an antibody-independent phenomenon.

Agammaglobulinemic chickens died with fulminating parasitemias following infection with P. gallinaceum. When rescued from otherwise fatal infection by means of chloroquine therapy, B-cell deficient chickens resisted challenge infection with the same parasite. The data suggest that nonsterilizing immunity to malaria in chickens is B-cell independent.

Agammaglobulinemia↗
PubMed1976

Pre-intestinal stability of beta-carotene in ruminants.

The stability of beta-carotene in the rumen contents of cows, calves and sheep was investigated in vitro and in vivo. Incubation tests with rumen liquor consistently showed that carotene was relatively stable, less than 10% losses being found under a wide variety of incubation conditions and with different sources of carotene. There was no relation between the small carotene losses and the extent of fatty acid hydrogenation. Rumen liquor samples taken from a fistulated cow over a 24 h period after the feeding of alfalfa meal had a nearly constant ratio of carotene to unsaponifiable matter. Carotene was injected into the rumen of a ram after surgical ligation of the pylorus. The recovery of carotene from the combined contents of the reticulo-rumen, omassum and abomasum 24 h later amounted to 89% whereas vitamin A palmitate, under the same conditions, yielded a recovery of 70%. It is concluded that little carotene is lost normally during its passage through the pre-intestinal part of the alimentary canal of ruminants.

Animal Nutritional Physiological Phenomena↗
PubMed1976

Low utilization of carotene by sheep.

The apparent digestibility of beta-carotene was determined in Awassi rams by means of balance trials. In a first series carotene was supplied per os in constant daily amounts ranging from 2.88 to 8.52 mg in the form of pelleted alfalfa meal or as a water-dispersible synthetic preparation. The supplements were given with a basal low-carotene ration composed of barley, soybean meal and straw and supplying 82 mug carotene daily. Fecal recoveries for the carotene supplements ranged from 92 to 98%, whereas the unsupplemented basal diet yielded a recovery of 28%. In a second series single doses of carotene in various carriers were introduced into the abomasum of fistulated rams. With an aqueous carotene dispersion fecal recoveries were close to 90%. When dissolved in triglycerides, carotene yielded less than 50% recovery in the feces, and free fatty acids and monoglycerides gave intermediate values. Additional tests with 3H-labelled carotene revealed that the low fecal recovery of carotene given in oil was not due to improved absorption but to degradation of carotene in the lower intestinal tract. This was confirmed by measurement of blood radioactivity. The results show that carotene from different sources and with intakes bordering on minimum requirements is poorly absorbed by sheep. It is suggested that the peculair physiology of digestion in the ruminant creates unfavorable conditions for the efficient micellar solubilization of nonpolar lipids in the upper small intestine.

Abomasum↗
PubMed1975

The effect of alfalfa saponins on growth and lysis of Physarum polycephalum.

The prelytic events associated with the interaction of saponins with Physarum polycephalum membrane components were studied. It was found that alfalfa saponins form interaction products with membranal sterols, proteins and phospholipids. The interaction of saponins with proteins affect also certain membranal enzymic activities such as NADH oxidase and Malate dehydrogenase. It is suggested that although the interaction of the saponin with sterols is much more specific than with other membranal components, the lysis of plasmodia of P. polycephalum should be attributed to a concerted attack on the various membrane constituents. In continuation of these interactions, the changes of permeability of plasmodia membrane were expressed by increment of inorganic sodium ions and water influx, traced by lysis, while no efflux of ions was observed.

Cell Membrane↗
PubMed1975

Solubility and net exchange of calcium, magnesium and phosphorus in digesta flowing along the gut of the sheep.

1. The changes in the solubility of calcium, magnesium and phosphorus in digesta flowing along the intestinal tract and the net movement across the intestinal wall of these elements were determined in six rams, each equipped with three T-shaped cannulas; cannulas were placed in a total of six different sites of the small intestine. Cr2O3 was used as a marker substance to measure the rate of flow of the digesta. 2. The concentrations of soluble Ca, Mg and P decreased as digesta moved along the intestine. TheMgreatest fall in soluble Ca occurred after the first 3 m of the intestine, while a significant decrease in soluble Mg was found only at 15 and 25 m from the pylorus. The concentration of soluble P in digesta decreased until the 7 m site and then remained stable. In the faeces, the level of soluble Mg was approximately 4 times higher than, and that of Ca equal to, the levels of Mg and Ca found in digesta flowing through the upper intestine. Unlike Ca and Mg, a very low concentration of soluble P was found in the faeces. 3. In the duodenum, 84, 78 and 62% of the total Ca, Mg and P respectively were soluble, whereas in the digesta flowing through the terminal ileum the corresponding values were 3-2, 7-2 and 19% for Ca, Mg and P respectively. 4. The forestomachs and the colon were found to be the main sites of g net absorption; 1-12 mmol/h was apparently absorbed from the stomach and 1-05 mmol/h from the colon. The supper small intestine (1-3 m from the pylorus) appeared to be the major site of Ca and P absorption. 5. In the last 10 m of the small intestine, considerable amounts of minerals were secreted; 4-70, 0-96 and 1-85 mmol Ca, Mg and P/h respectively were added to the digesta flowing between 15 and 25 m from the pylorus. The effect of the increase in the pH of digesta along the small intestine on the solubility of these minerals is discussed.

Animals↗