[Chronic obstructive bronchopneumopathy in intensive therapy].
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Biomedical subjects
Publications and source records attributed to A Bondoli.
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A study on two groups of patients in acute respiratory failure with hypercapnia (18 subjects) and in hypercapnic coma (18 subjects) has been carried out to determine the related changes in sodium ion, potassium ion, chloride ion, urea and osmolality in blood and cerebrospinal fluid. There were significant differences between the two pathological states and particularly in coma, changes in transmembrane active transport of electrolytes are significantly related to high concentrations of CO2 in the brain.
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An experimental study on the protein and aminoacid cerebral metabolism in Barbiturate poisoning coma has been carried out. Some significant alterations in central aminoacid pattern have been found. These changes suggested Hypothesis on particular biochemical pathways of brain tissue related to the pathological status. An attempt of correlation between the aminoacid alterations and cerebral energetic need is also reported.