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Biomedical subjects

A Bonow

Publications and source records attributed to A Bonow.

At least 19 recordsLinked to original sources
PubMed1982

Pharmacokinetics during pregnancy and delivery.

The pharmacokinetics of certain drugs were studied in the following patient groups: in women in stage III of pregnancy, in women in labor, and in non-pregnant women as a control group. In late gravidity several parameters of distribution and elimination change. Nevertheless, it is not necessary to modify the usual dose schedule. However, sulfonamides and antibiotics should be administered in the upper range of dosage. In contrast to late pregnancy, we found elimination of drugs to be always retarded during labor. Attention must be paid to accumulation, which may occur.

Female↗
PubMed1981

[Behaviour of Butanol-extractable iodine in serum, during and after long-time application of hormonal contraceptives (author's transl)].

The behaviour of butanol-extractable iodine in serum was tested, during and on completion of administration of Non-Ovlon, Ovosiston, Gravistat, and Deposiston, the latter being a longacting contraceptive. Action of synthetic sexual steroids led to an increase in butanol-extractable iodine. However, this change proved to be easily reversible, soon after the end of medication, even after long-time application. Yet, complete normalisation should not be expected to occur before the second cycle without contraceptives, which applies, in particular, to women who had been on long-acting contraceptives.

Adult↗
PubMed1980

Research on pharmacokinetics during pregnancy.

The pharmacokinetics of some drugs important for treatment in pregnancy were studied in several groups, women in stage III of pregnancy, women in labour and non-pregnant women as a control group. The half-life of elimination of the drugs is one of the most important parameters in pharmacokinetics. The following drugs were used: noramidopyrine methane sulphonate sodium, aminophenyzone, pethidine, methaqualone, ampicillin, cephalothin, chlorsulfamethin, and indocyanine green. The results show that all drugs except cephalothin had a prolonged half-life during labour. In contrast to this the half-life of most of the drugs is diminished in pregnancy. The extent and direction of the changes depend on the pathway of elimination and on the rate of biotransformation of the drug.

Biotransformation↗
PubMed1979

[Studies on the kinetics of methaqualone during the late stage of pregnancy (author's transl)].

After oral administration of 0.4 g of methaqualone to pregnant and non-pregnant women, the authors stated that the half-life of this drug was significantly reduced during the last trimester of pregnancy. The two experimental groups showed no significant differences in the volume of distribution and the fictitious initial concentration. The commonly used therapeutical dosages are not likely to produce increased blood levels during normal pregnancy.

Female↗
PubMed1978

Age-dependence of renal tubular reabsorption of nitrofurantoin.

Nitrofurantoin is rapidly excreted in adult rats. However, in 5 to 15 days old rats the renal excretion of nitrofurantoin is diminshed by a high rate of reabsorption. Because nitrofurantoin has a pKa of 7.2 its tubular reabsorption is influenced by the urine pH but is independent of urine flow. About 50% of an administered dose of nitrofurantoin is recovered as metabolites in the urine of both young and adult rats. Probenecid blocks the active tubular secretion of nitrofurantoin independently of age and reduces its rate of renal clearance. Induction of drug metabolizing enzymes by pretreatment with phenobarbital was without effect either on the metabolism or renal excretion of nitrofurantoin nor could the renal excretion of this drug be diminished by repeated administration. The age-dependent difference in the rate of renal excretion of nitrofurantion is due to the high rate of tubular reabsorption in the young animals. This study provides experimental support for the therapeutic use of nitrofurantoin in the neonatal period.

Absorption↗
PubMed1977

[Long-term effect of hormonal contraceptives on the behavior of serum lipids].

In order to check the long-term effects of oral contraceptives used in the GDR on certain serum-lipid-fractions, triglycerides, phospholipids, total and free cholesterol, and beta-lipoproteins were determined in four groups of 15 women each, taking the contraceptive preparations Ovosiston, Nonovlon, Gravistat, and Deposiston. Determinations were carried out before and following 3, 6, 12, and 18 month of drug administration. Statistically significant increases of triglycerides occurred under the combined preparations, of phospholipids under Ovosiston and Deposiston and of the beta-lipoproteins under Ovosiston and Gravistat. Total cholesterol showed a slight decrease under all preparations tested. At present the prognostic significance of these slight alterations of serum-lipid-concentrations cannot be estimated completely.

Adult↗
PubMed1975

[Studies on the kinetics of sulfaclomide and the effect of sulfaclomide therapy on p-aminohippuric acid clearance in pregnancy].

After a single oral dose and after 11 day repeated administration of Sulfaclomide elimination half-life of Sulfaclomid was not different in pregnant and in nonpregnant women. The initial serum concentrations of Sulfaclomid are lower in pregnant than in nonpregnant persons. Nearly all Sulfaclomid measurable in serum exists from unchanged sulfonamide. This rate does not change during treatment. By treatment with Sulfaclomid elimination half-life of p-aminohippurate (PAH) is shortened, renal excretion of p-aminohippurate is significant increased.

Aminohippuric Acids↗