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Biomedical subjects

A Borromei

Publications and source records attributed to A Borromei.

At least 19 recordsLinked to original sources
PubMed1995

[Multiple sclerosis. A report of a case treated with thymopentin].

The authors analyse the case of a 58-year-old male suffering from substantially "atypical" multiple sclerosis (MS), both in terms of the late onset and because of some characteristics of the course of disease. The patient was treated with a subcutaneous immunomodulator (thymopentin) at a dose of 50 mg/day in 3-monthly cycles with intervals of 2 months between cycles, for a total of 3 cycles. Instrumental (CAT-NMR) and laboratory (immunological) tests were not significant, whereas others provided complex responses that allowed the presence of a demyelinating syndrome to be ascertained, above all due to the positivity of isoelectrofocusing. Treatment with thymopentin, commenced 12 years after the clinical onset of disease and after numerous cycles of cortisone and ACTH therapy, led to a major improvement in clinical conditions, especially of "sthenia" and movement, with consequent recovery of personal autonomy and working capacity which had previously been totally lost. Immunological tests performed at the end of each treatment cycle showed some slight but interesting modifications in parameters relating to DNA and the percentage of HLA antigens bound to lymphocytes. These findings suggest that the patient's immune system was sensitive to treatment with the thymic hormone responsible for the objective clinical improvement. These results appear to open the way to the possible treatment with immunomodulators.

Adjuvants, Immunologic↗
PubMed1989

[Nonpsychotic involutional inhibited depressions and psycho-organic deteriorations: treatment with Viloxazine and piracetam].

Involutional depression is often the first symptom of a psycho-organic syndrome or dementia and may not present overt symptoms itself; these depressive states have been variously classified by different schools in various countries. The hypothesis of catecholamine and indolamine in the aetiopathogenic agent is oversimplistic and the theory that abnormal receptor hypersensitivity is the cause of the condition is more convincing. On the basis of this hypothesis numerous studies have been conducted into the efficacy of various antidepressants in the treatment of this hypersensitivity. Involutional depressions are more common among women and are found in about 10% of 60-65 year olds. This report claims that combined viloxazine-piracetam is the most appropriate treatment for involutional depression. This approach (200 mg oral viloxazine and 9 g oral piracetam a day) was adopted for 3 months in 33 out patients about 64 years old who were subsequently put on maintenance doses (100 mg viloxazine, 3 g piracetam a day). The various Hamilton scale parameters were assessed as were reaction times to auditory and visual simple stimuli. Result sat the start and end of treatment were then compared. About three quarters of the patients showed improvement in both depression and psycho-organic syndrome symptoms, while total remission or lasting improvement in both pathologies was obtained in about 50%.

Administration, Oral↗
PubMed1987

[Neurotraumatology and post-traumatic epilepsy. Prevention, treatment and long-term follow-up. Barbexaclone + phenobarbital (maliasin) versus diphenylhydantoin, phenobarbital, primidone, carbamazepine].

A report is presented on 58 patients (46 males, 12 females) all suffering from post-traumatic epilepsy (PTE) and followed up for a minimum of 1 year to maximum of 23 years after the injury (mean 6.3 years). The type and site of the head injury, the nature of the brain lesions, the time elapsing before the first critical manifestation, the clinical character of the epileptic attacks, EEG, cerebral CAT and RMN data were performed are given for all patients. The therapeutic and prophylactic strategies adopted are then described in detail with particular emphasis on the use of diphenylhydantoin (DPH) and barbexaclone. The latter drug, used for the last 3 years was found to be particularly useful in the treatment of patients suffering from a post-traumatic psycho-organic syndrome in addition to the PTE.

Adolescent↗
PubMed1985

Involutional dementias: new perspectives.

13 patients with psycho-organic syndrome (POS) and 10 patients with dementia (senile, Alzheimer, multi-infarct) were treated with drugs considered to influence the neuronal turnover of acetylcholine (Phosphatidylcholine, piracetam, S-adenosylmethionine) for 30 days and compared in respect of CSF ACh levels, reaction times to simple visual stimuli (TRS-V) and to simple hearing stimuli (TRS-H) and scores on the Sandoz Clinical Assessment Geriatric (SCAG) rating scale. The POS patients presented higher CSF ACh levels, shorter TRS-V and TRS-H times and lower SCAG scores than the demented patients before treatment. During treatment the CSF ACh values fell in the POS but not in the demented patients. All the other values improved in both groups but more markedly in the POS group. The CSF ACh variations in the latter appear to correlate with the variations in TRS-V and TRS-H times and SCAG scores. The monitoring of CSF ACh would seem to be useful in assessing both the degree of decline in dementia and the possibilities of treatment in individual patients.

Aged↗
PubMed1984

[Rational medical and surgical therapy of essential facial hemispasm. Experiences in 21 cases].

After a brief review of the definition, aetiopathogenetic hypotheses and various medical and surgical treatment of idiopathic hemifacial spasm, 21 personal cases are reported. It is concluded that the most effective treatment is surgical release of the compressed nerve with various types of vascular loop. The most effective medical treatment is large doses of carbamazepine, though it does not always produce a lasting improvement.

Adult↗
PubMed1980

[Tetraventricular ependymoma. Presentation of a case].

The clinical study of encephalic ependymoma shows that cases present with polymorphous clinical pictures depending on intra and/or periventricular tumoural growth, generally such as to hinder precise diagnosis during life, unless under direct control, or, currently, using computerized axial tomography. The reported case, completed by macro and microscopic autoptic study, takes on particular importance because the neoplasia involved all encephalic ventricular cavities. This exceptional localisation and extension, only gave an aspecific clinical picture, dominated by the presence of a slight internal communicating type hydrocephalus and immediate general convulsive signs.

Adult↗
PubMed1977

[EEG screening of candidates for underwater activity].

Following a review of a number of EEC recording technique, a screening technique for candidates for sporting and/or professional underwater activities is proposed in replacement of the routine examinations which are considered unsuitable. Modalities are described involving basic recordings in hyperpnoea and 12 tests in apnoea. Examples are given and the practical advantages of the proposed technique are discussed in the light of experience.

Adult↗