Biomedical subjects

A Borsche

Publications and source records attributed to A Borsche.

12 recordsLinked to original sources

PubMed1999

[Burn sequelae in developing countries].

Based on their experience in the reconstruction of burn sequelae acquired over the last decade in India and Africa, the authors try to define a number of elements applicable to every case and in every country: the importance of preparation of missions in the foreign country and in France, concerning material and all team personnel; the particular conditions of anaesthesia-intensive care; surgical criteria of efficacy, rapidity, simplicity and reproducibility. Full-thickness skin grafts and reliable local or regional flaps are the preferred techniques. The authors consider that there is no place for expansion prostheses and microsurgical free flaps in this setting.

Adult↗

PubMed1995

[Surgical therapy in the second stage after burn injuries with special reference to reconstruction of face and hands].

Surgical reconstruction in the second stage after burn injury requires an individual approach. The possibilities are determined primarily by the extent of the injury. The timing of the surgery is very important, and functional, aesthetic and psychological aspects must be taken into consideration in each case. Plastic surgery is only one part of the rehabilitation of the burn patients. Examples are given of possible reconstructive procedures for the face and hands.

Adolescent↗

PubMed1992

Efficacy, tolerability and pharmacokinetics of teicoplanin in patients undergoing breast surgery.

In a prospective open trial, 21 female patients undergoing breast surgery received a single intravenous bolus injection of teicoplanin, 400 mg, 30 minutes before the operation. During surgery, (1 hour after teicoplanin administration), samples of breast and fat tissue and serum were collected; 24 hours and 48 hours after dosing, samples of wound exudate were taken. Teicoplanin concentrations were determined using the RASA method. Teicoplanin levels were lowest in fat tissue. Teicoplanin levels in wound exudate were found to be satisfactorily high. However, teicoplanin levels in fat and breast tissue and in wound exudate exceeded the MIC90 for various staphylococcus strains, such as S. aureus and S. epidermidis. No local or systemic adverse reactions were observed during the trial. Teicoplanin was well tolerated. Preliminary results from this trial, therefore, indicate that teicoplanin may be a suitable antibiotic for use in the prophylaxis of infection in breast surgery.

Adult↗

PubMed1982

Effects of fully synthetic human insulin in comparison to porcine insulin in normal subjects.

Fully synthetic human insulin (CGP 12'831) was compared to porcine insulin in identical and non-identical formula by intravenous insulin tolerance tests in 12 volunteers. The half-lives of the three insulins tested did not differ (t 1/2: 5.5 +/- 0.2 minutes), though acid porcine insulin exhibited lower serum peak values. The hypoglycemic effects of the three insulins were identical. Human insulin produced a significantly smaller decrease in serum potassium (2p less than 0.01). The secretion of serum C-peptide was less inhibited by human insulin (2p less than 0.05). The counter-regulatory hormonal response of cortisol and growth hormone was lower after hypoglycemia induced by human insulin (2p less than 0.05). It is suggested that the hormonal effects of hypoglycemia are modified by insulin and depend in part on the molecular structure of insulin.

Animals↗

PubMed1981

Effects of fully synthetic human insulin in comparison to porcine insulin in normal subjects.

Fully synthetic human insulin (CGP 12'831) was compared to porcine insulin in identical and non-identical formulation by intravenous insulin tolerance tests in 12 volunteers. The half-lives of the three insulins tested did not differ (t 1/2: 5.5 +/- 0.2 minutes), though acid porcine insulin exhibited lower serum peak values. The hypoglycemic effects of the three insulins were identical. Human insulin produced a significantly smaller decrease in serum potassium (2p less than 0.01). The secretion of serum C-peptide was less inhibited by human insulin (2p less than 0.05). The counter-regulatory hormonal response of cortisol and growth hormone was lower after hypoglycemia induced by human insulin (2p less than 0.05). It is suggested that the hormonal effects of hypoglycemia are modified by human insulin and depend in part on the molecular structure of insulin.

Adult↗

PubMed1976