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Biomedical subjects

A Boznański

Publications and source records attributed to A Boznański.

At least 19 recordsLinked to original sources
PubMed2000

[Undesirable pharmacokinetic interactions of theophylline].

Theophylline and other methylxanthines are the strongest and most widely used antiasthmatic drugs. Mechanism of theophylline effect is complicated. The first observations of this way, depend on inhibition of phosphodiesterase by increase of cAMP what is the reason of bronchorelaxation. As a results a theophylline action we can observe induction of adenosine receptors, inhibition of the some prostaglandin synthesis or allergic reaction mediatores and decrease of the level of calcium in muscles cells. It is probably (especially in bronchial asthma or acute lymphoblastic leukemia-ALL) that the one important effect of theophylline is the some cells apoptosis. For the good results of the therapeutics effect apart of important factors deciding of the theophylline metabolism (age of patients, kind of the diet, period of menstruation and smoking), we always should consider interactions of theophylline with other drugs. In this paper we presented the most often reasons of interactions between theophylline and others drugs.

Apoptosis↗
PubMed1998

[The level of RANTES and interleukin-8 in serum of children with bronchial asthma after an exercise test].

The study was carried out on 20 children with bronchial asthma. After the exercise induced test we observed decreased serum level of RANTES both in children with positive and negative results of the test. Serum level of IL-8 was increased in all examined group. We found strong correlation between serum level of RANTES and peripheral blood eosinophil counts in children with positive result of the test before and after the exercise.

Adolescent↗
PubMed1996

[Serum levels of sCD23 and IL-4 concentration in stimulated PBMC in children with atopic diseases].

In this study we estimated the correlation between IgE and sCD23 serum levels, and the concentration of IL-4 in PHA-stimulated PBMC cultures in children with atopic diseases. Children with atopic dermatitis showed a high degree of correlation between sCD23-IgE while in the control group no such relationship was found. We also found no relationship between IL-4 and sCD23 in children with atopic asthma, relationship at children with atopic dermatitis, and no relationship in healthy children. Looking for relationship between IL-4 in PHA-stimulated PBMC and IgE serum levels we discovered a weak negative correlation in children with atopic asthma, a highly positive correlation in children with atopic dermatitis and no relationship in the control group.

Adolescent↗
PubMed1996

[Effect of immunotherapy on selected immunologic indices in children with pollinosis].

The study was carried out on 15 children with pollinosis. The children were treated with "Pollinex-Bencard" before the pollen season. We looked for changes of serum IgE levels and percentages of T (CD3) cells and their subsets CD4, CD8. After immunotherapy we observed a significant decrease of CD3, CD4 and CD8 cells, whereas no statistical difference was observed in the CD4/CD8 ratio. Three months after immunotherapy, serum IgE levels were significantly elevated, while after 9 months, markedly decreased.

Adolescent↗
PubMed1996

[Evaluation of soluble components of receptors with weak affinity for IgE (sCD23) in children with pollinosis given specific immunotherapy].

The aim of this study was the evaluation of the measurement of sCD23 and IgE levels before and after immunotherapy. The research was conducted in a group of 23 children aged 6 to 18 years with pollinosis diagnosed on the basis of the patient's history, increased IgE level and positive skin tests with pollen allergens. The control group consisted of 10 healthy children in the same age with normal IgE level. The treated children were examined before and 6 weeks after immunotherapy. Before immunotherapy in both groups of children (with the high and medium IgE level) the sCD23 concentration was statistically higher (level of significance p < 0.001) compared to the sCD23 level in the healthy children. After immunotherapy we observed significant decrease of the sCD23 level. We did not found correlation between sCD23 and IgE in children with pollinosis before and after immunotherapy.

Adolescent↗
PubMed1995

T-lymphocyte subpopulations (CD4, CD8), IL-4 and IFN-gamma concentration in stimulated cell culture (PBMC) in children with atopic dermatitis.

The study was carried out on a group of children with atopic dermatitis. We were looking for a correlation between the percentages of CD4, CD8 lymphocytes and IFN-gamma and IL-4 concentrations in stimulated PHA cells cultures (PBMC). On the ground of obtained results, a statistically significant increase of IL-4 concentration in children with atopic dermatitis and a correlation between CD4 cells and IFN-gamma concentration was found.

CD4-CD8 Ratio↗
PubMed1995

Specific IgE against milk allergens in children with insulin dependent diabetes mellitus.

Cow's milk has been considered as a possible trigger of the autoimmune response that destroys pancreatic B-cells, thus causing insulin dependent diabetes mellitus. We investigated 46 children with IDDM. In this group we showed an increased total IgE in 58.6% of cases and the presence of specific IgE antibodies induced by milk allergens in 32.5% of cases. These results suggests that antibodies probably play an important role in IDDM pathogenesis.

Adolescent↗
PubMed1994

[Preliminary evaluation of efficacy for the preparation DNCG-compositum in treatment of atopic bronchial asthma in children].

Preparations, in which composition disodium cromoglycate goes into, have been for many years the admitted way of bronchial asthma treatment. The introduction, to the therapy, of preparation that contains reproterol as well makes possible the early remission of disease symptoms. The aim of the study was the estimation of the effectiveness of DNCG-comp. preparation. Twenty one children, aged 7-17 years, with recognized bronchial asthma were examined. The atopic basis of the disease was found on the ground of results of skin prick tests, and elevated concentration of serum IgE and positive atopic family interview. We resigned the hitherto treatment for 3 days, carried out the spirometric measurements (PEF, FEV1, FEV1%VC, MEF25,50,75). DNCG-comp. was given 4-times per twenty-four hours in 2 inhalations at each time, for three weeks. Every day, the PEF value and the score of disease symptoms were established. After the study, side effects were not observed and final results of spirometric estimation evidence the possibility of wide application of DNCG-comp. preparation in the treatment of bronchial asthma in childhood.

Administration, Inhalation↗
PubMed1993

[Pulmonary miliary tuberculosis in a 14-year old boy].

A case is presented of a rare form of pulmonary miliary tuberculosis in a 14-year-old boy beginning with dramatic symptoms with negative the test and negative result of bacterioscopy. The preliminary diagnosis was made on the basis of clinical observation and radiological examination. Confirmation was achieved after obtaining of a positive result of bacteriological examination.

Adolescent↗
PubMed1993

[Netherton's syndrome in a 12-year old girl].

A case is presented of a 12-year-old girl with skin changes existing since birth which (in spite of the lack of changes in hair structure) were regarded as a coexistence of generalized ichthyosiform erythrodermia and atopic dermatitis, and which were diagnosed on the basis of literature data as Netherton's syndrome. Several weeks of treatment with non-steroid ointments, new generation antihistamines with the use of elimination diet gave an evident improvement and made possible her discharge in fairly good general condition, with suggested further treatment in the allergy outpatient clinic.

Child↗