Biomedical subjects

A Brazão

Publications and source records attributed to A Brazão.

3 recordsLinked to original sources

PubMed1997

[Left ventricular aneurysm. The surgical results and follow-up].

From May 1988 through October 1994, 44 patients with ischemic left ventricular aneurysm were operated upon. The mean age was 60.5 +/- 7.7 years and 36 patients (81.8%) were male. Thirty-two patients (72.7%) had congestive heart failure in NYHA class II or greater and 26 (59.1%) had moderate or severe left ventricular dysfunction. In 41 cases (93.2%) there was a history or electrocardiographic signs of myocardial infarction and only 3 patients (6.8%) were angina free. The location of the aneurysms was antero-apical or antero-lateral in 37 patients (84.1%) and inferior in 7 (15.9%), and intracavitary clot was present in 9 cases (20.5%). Fifteen patients (34.1%) were operated upon using standard linear repair, 8 (18.2%) by Stoney's technique and in the remaining 21 (47.7%) an endoventricular patch plasty was performed. All patients but one had CABG with a mean of 2.7 grafts per patient. The IMA was used in all patients with graftable LA disease (90.0%). Double IMA grafting was used in 10 patients (22.7%). Three patients (6.8%) had associated valvular surgery. Hospital mortality was 2.3% (1 patient) and morbidity 22.7% (10 patients); intra-aortic balloon counterpulsation was required in two patients. The mean time of hospitalization was 13.5 +/- 9.0 days. In the follow-up period (mean 29.2 +/- 21.5 months), 6 patients had required hospitalization (left ventricular failure -4; supraventricular arrhythmia-2) and two died. The remaining 32 survivors (78.0%) are in functional class I of the NYHA, without angina. Surgery of left ventricular ischaemic aneurysm was possible with low mortality and morbidity, with good functional results.

Adult↗

PubMed1997

[Surgery for acute type-A aortic dissection].

From January 1989 through June 1996, 29 patients underwent surgical repair of type A acute aortic dissection. Mean age was 59 +/- 13.5 years (range 25-76 yrs) and 21 patients (72.4%) were male. Nineteen patients (65.5%) had systemic hypertension and 3 (10.3%) Marfan syndrome. One patient (3.4%) had prior surgical repair of descending aortic dissection and CABG. Six patients (20.7%) were operated on in shock. The dissection was limited to the ascending aorta (DeBakey type II) in 12 patients (41.4%). Eleven patients (37.9%) had severe aortic regurgitation. Replacement of the ascending aorta was performed in all cases and extended to include the transverse arch in one. Twenty-three patients (79.3%) were operated upon using a tubular graft (sacron-21, homograft-2) with aortic valve resuspension. In the remaining 6 (20.7%) the aortic valve and root were replaced using a Bentall procedure, modified with a homograft in 3 cases. Five patients (17.2%) had associated surgery: CABG (4) and closure of aortic-atrial fistula (1). Mean cardiopulmonary bypass time was 134 minutes (range 70 to 285 min) and aortic cross-clamp time was 58 minutes (range 23 to 93 min). Hypothermic circulatory arrest for open distal anastomosis was used in 26 patients (89.7%) (mean time 22 min; range 10 to 32 min), with retrograde cerebral perfusion in the last 4 years (18 cases; 62.1%). Hospital mortality was 17.2% (5 patients). Eight patients (27.6%) had hospital morbidity: reexploration for bleeding (4 cases), CVA (3), A-V block necessitating permanent pacemaker (1). The mean time of hospitalization was 18 days (range 9 to 81 days). In the follow-up period (mean 38 mths; range 4 to 94 mths), 2 patients died (CVA and gastrointestinal bleeding) and 4 required hospitalization (perforated duodenal ulcer, peritonitis, suspected endocarditis, supraventricular tachyarrhythmia-1 patient each). All 22 survivors (75.9%) returned to the functional status they had prior to the dissection and 18 of them (81.8%) are in NYHA functional class I. Type A acute aortic dissection is a complex pathology and the postoperative mortality remains significant, but surgery permits good functional recovery and an active life for the survivors.

Acute Disease↗

PubMed1996

[Homograft replacement of aortic valve and ascending aorta].

From May 1990 through December 1994, integral valved aortic homografts were implanted for replacement of the aortic valve and of part or the whole of the ascending aorta in 24 patients with a mean age of 45.5 years (17-66 years). Ten patients (41.7%) had infective endocarditis of the aortic valve (4 of the native valve and 6 prosthetic). Seven of these had root abscesses (70%), one with a fistula to the right atrium, resulting in a variable degree of discontinuity between the left ventricle and the aorta. Twelve patients (50%) had ascending aortic aneurysms and the remaining two (8.3%) had aortic dissection. Three patients (12.5%) also had mitral pathology, one had triple vessel coronary disease, one had aortic coarctation and another one had a sub-aortic membrane. Two thirds of the patients were in NYHA class III/IV and 10 (41.7%) had moderate or severe left ventricular dysfunction. A modified Bentall technique utilising fresh aortic homografts was used in all patients. The homografts were harvested aseptically from donors with a mean age of 30 years (16-54 years) and preserved at 4 degrees C for a period of 1-43 days (median-13 days). Six patients (25%) had associated surgery: mitral valve replacement; mitral valvuloplasty with a ring; closure of aortic- atrial fistula, resection of sub-aortic membrane; triple coronary artery bypass; and mitral and tricuspid annuloplasty and closure of ASD (one patient each). Postoperatively three patients (12.5%) required reexploration for excessive blood drainage in the first hours and one patient with complete A-V block required a pacemaker (4.2%). Hospital mortality was 4.2% (one patient). At the time of discharge, no patient had significant Doppler or echocardiographic aortic gradient or regurgitation. All patients were followed for a mean period of 31 months (7-62 months). One patient died of a non cardiac death and the remainder are in NYHA class I without thromboembolic or haemorrhagic accidents and with echocardiographic findings similar to those observed at discharge. These results suggest that aortic homografts constitute an effective and safe method of reestablishing the continuity between left ventricle and aorta, especially in the presence of an infective process with root abscesses.

Adolescent↗