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Biomedical subjects

A Breed

Publications and source records attributed to A Breed.

9 recordsLinked to original sources
PubMed1989

Arthrography in the evaluation of congenital dislocation of the hip.

To assess the value of intraoperative arthrography, 48 preoperative hip arthrograms of 35 children under 18 months of age treated for congenital dysplasia of the hip were reviewed. The frequency of the common arthrographic observations was assessed and was compared with the findings observed from the plain roentgenograms, and with the pathoanatomy seen at the time of open reduction. Arthrography proved reliable in identifying the depth of reduction (medial dye column, 100%), the configuration of the osteocartilaginous structures (96%), and the presence of potentially obstructing soft tissue (limbus, 98%, and ligamentum teres, 78%). Arthrography was less reliable in discerning psoas contracture (36%), despite its presence at all open reductions. Arthrography proved reliable in outlining the inverted limbus that can obstruct closed reduction. Because ossification of the femoral head was frequently eccentric, the center edge (CE) angle of Wiberg was calculated from arthrography more accurately than from roentgenograms.

Acetabulum↗
PubMed1988

Deletion (8)(q22) as the only chromosomal abnormality in a patient with RAEB-t with progression to acute myelocytic leukemia.

Cytogenetic investigation of the bone marrow cells of an 88-year-old woman with refractory anemia with an excess of blasts in transformation with progression to acute myelocytic leukemia (AML), FAB classification M4, revealed a deleted chromosome #8 with the breakpoint at band q22 as the sole abnormality. This breakpoint is the same as that in t(8;21)(q22;q22), mostly found in patients with AML. This finding is discussed in relation to the possible oncogenesis of AML, which in this case may mean that the deletion of chromosome #8 at band 8q22 and the resultant loss of genetic material with possible antioncogenic activity is the critical event leading to malignant transformation in AML and not the translocation of the end of 21q next to 8q.

Aged↗
PubMed1986

A family with lobus venae azygos.

Lobus venae azygos was found in five out of 12 members of one family. There is vertical transmission of the abnormality through three generations. The mode of inheritance is probably autosomal dominant.

Azygos Vein↗
PubMed1985

Segmental spinal instrumentation without sublaminar wires.

We have developed a method of segmental spinal instrumentation that precludes the passage of sublaminar wires, thus reducing the likelihood of neurological complications. The technique utilizes the base of the spinous process as the purchase site for segmental fixation and a newly developed button-wire implant. The technique and early experience with this method are described.

Adolescent↗
PubMed1984

Interspinous process segmental spinal instrumentation.

A method for interspinous segmental spinal instrumentation (ISSI) is described and the laboratory testing and early clinical results are reported. The method utilizes a button-wire implant that is passed through the thickest and strongest part of the base of the spinous process. Tension tests show the stress-relieving qualities of the implant improve pullout strength 47% over simple wire fixation of the spinous process. Tests on the scoliosis simulator show that the interspinous instrumented spine resists high compressive loads to failure, comparing favorably with other systems tested. Early clinical experience with the implant for a wide variety of uses has been encouraging. The authors use ISSI as their procedure of choice in idiopathic and congenital scoliosis.

Adolescent↗
PubMed1984

Improved postoperative course following modified segmental instrumentation and posterior spinal fusion for idiopathic scoliosis.

Postoperative course following posterior spinal fusion was reviewed and compared for 31 patients who underwent Harrington distraction instrumentation and 30 patients who underwent modified segmental spinal instrumentation (SSI). The SSI patients, on average, received oral feedings 1 day earlier (p less than 0.046), walked 5 days earlier (p less than 0.001), and were discharged 5 days sooner (p less than 0.001) than patients undergoing Harrington distraction. Despite this more active postoperative course, the SSI patients did not require more analgesics or narcotics. When the hospital costs were compared, there was a savings of $2,825 for the average patient undergoing SSI.

Adolescent↗
PubMedDate not supplied

Abnormal karyotype in the chorion, not confirmed in a subsequently aborted fetus.

An abnormal fetal karyotype, containing a del 16(q21-qter) as an extra chromosome, was diagnosed in all 14 metaphases examined in a sample of chorionic villous biopsy material. After elective abortion a mosaicism for this cell-line together with a normal one was detected in the chorionic tissue. Fibroblast cultures from several fetal skin biopsies all revealed a normal karyotype.

Abortion, Eugenic↗
PubMedDate not supplied

Prevention of fixed, angular kyphosis in achondroplasia.

Transient kyphotic deformity arises in most infants with achondroplasia. In a minority, a fixed and angular kyphosis develops, which can cause serious neurologic sequelae later in life. We assessed a protocol for preventing development of such fixed kyphosis in a sequential, unselected series of 66 infants with achondroplasia. This study demonstrates the efficacy of early prohibition of unsupported sitting and, in those in whom such prohibition proves insufficient, use of bracing. When the proposed algorithm was followed, none of the infants had development of a progressive kyphotic deformity. On this basis, it appears that the secondary risks of angular kyphosis, previously estimated to be between 10 and 15% in individuals with achondroplasia, can be completely eliminated.

Achondroplasia↗