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Biomedical subjects

A Briggs

Publications and source records attributed to A Briggs.

9 recordsLinked to original sources
PubMed1979

Familial partial trisomy of the long arm of chromosome 3 (3q).

A case of partial trisomy of the long arm of chromosome 3 (3q21 leads to qter) is described. The clinical findings are compared with those in 5 previously reported cases. There is hirsutism and characteristic facial dysmorphism, the common features of which are a square-shaped face, prominent nasal bridge, everted nostrils, hypertelorism, and palate abnormalities; occurring less often are abnormalities of vertebrae, thorax, and digits, or cardiovascular, urinogenital, and central nervous system. New features noted in this present case are absence of right eye from orbit and spina bifida. The spectrum of this syndrome is discussed, with possible relation to the degree of trisomy. The present case is the 6th to be reported with partial trisomy of the long arm of chromosome 3.

Child↗
PubMed1978

Interaction of hydralazine and hydrazone derivatives with contractile mechanisms in rabbit aortic smooth muscle.

The mechanism of action and relative potency of hydralazine (H) and tow hydrazone derivatives were investigated using isolated rabbit aortic strips. H, hydralazine acetone hydrazone (HA) and hydralazine butanone hydrazone (HBH) relaxed established K+ and norepinephrine (NE) contractures, and inhibited the development of contractures to these two agents on preincubation. H, HA and HBH increased the threshold to Ca++ and decreased the maximum tension responses during K+-Ca++-contractures (HA greater than H, P less than .05; HBH greater than H P less than .01). The Ca++-dependent and Ca++-independent components of NE contractures were both inhibited by H, HA and HBH. NE contractures were more sensitive to the effects of H than K+ contractures. These results are consistent with the conclusion that H and hydrazone derivatives produce effects on vascular muscle both by interactions with the fluxes of Ca++ from the extracellular space and effects on release from cell stores. However, other possibilities need to be assessed experimentally.

Animals↗
PubMed1976

A new freeze-drying technique for processing biological materials.

Wet granulation and dry blending are standard techniques used in tablet formulation. Both techniques impose limitations on the ability to produce homogeneous tablets with rapid dissolution and controllability of the matrix for active ingredients. This report describes the development and application of a new freeze-system using a swirling bath of Freon-12 to process sensitive biological materials. The frozen beads produced with this process are subsequently freeze-dried and may be used to produce precise tablets. The ultra rapid freezing (7-14 milliseconds) provided by the Freon-12 process yiels amorphous homogeneous spheres by retarding component migration which permits precise control of pH and redox potential in the final product. Dissolution of tablets prepared by this Du Pont process is so rapid (8-12 seconds) that a special testing technique is required for measurement of dissolution time. Improved recoveries of activity have been demonstrated for sensitive biological materials compared to conventional freeze-drying. The optimization of droplet sizes is controlled by injection rate, stream diameter and surface velocity of the Freon-12 bath. Droplet size control permits attainment of weight precision in the range of 0.6 +/- 0.06% for a final 50 mg tablet. This compares with a tablet weight precision of 1% to 2% typical of dry blending and wet granulating. Potential applications of this technology include pharmaceuticals and the production of ultra precise reagent tablets for the Du Pont Automatic Clinical Analyser.

Biological Products↗
PubMed1974

Health and education.

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Comprehensive Health Care↗