Biomedical subjects
Publications and source records attributed to A Brodison.
Intramural course of coronary arteries is a well known phenomenon on autopsy. On angiography, however, it is usually seen in relation to the left anterior descending artery. Clinically this entity may be associated with myocardial ischemia, infarction or sudden cardiac death. In this case we report an unusual angiographic finding of circumflex coronary bridging.
Thrombosis within the target vessel is one of the most feared complications associated with coronary intervention, as it is often associated with severe adverse clinical sequelae. This thrombosis is mediated via the activation and aggregation of platelets and therefore considerable effort has been directed at ways of inhibiting platelet function. It is now mandatory to consider the use of two and often three different antiplatelet agents, particularly when intracoronary stents are inserted. Using these regimes, many of the adverse clinical outcomes associated with platelet activation can be reduced.
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Despite the improvements in the pharmacological treatment of acute myocardial infarction, it is recognised that thrombolysis fails to reproduce reperfusion in a significant proportion of patients. Coronary interventional techniques have been shown to offer an alternative reperfusion strategy. There is increasing evidence that mechanical reperfusion may offer significant advantages over established thrombolytic therapy.
Myocarditis is the end result of a heterogeneous group of conditions which cause inflammation of the myocardium. The resulting myocardial dysfunction may be responsible for significant morbidity and reduced life expectancy of the survivors. The condition is difficult to diagnose and treatment is on the whole rather unsatisfactory. Further work is undoubtedly required to identify methods for early identification of the condition and to develop better therapies aimed at preventing progression to chronic heart failure.