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Biomedical subjects

A Brorsson

Publications and source records attributed to A Brorsson.

8 recordsLinked to original sources
PubMed1998

Fears of disease and disability in elderly primary health care patients.

Some diseases are more frightening than others to patients and every culture or society has its own most dreaded disease(s). In some previous studies it has been shown that the fears of the patients sometimes have their roots in events in family history. In this qualitative study fourteen men and women aged 66-83 years, all of whom were primary care patients were interviewed with regard to their fears in connection with their present symptoms as well as in general. The results showed that diseases believed to entail disability, bodily changes and/or loss of control over body or environment, were the most feared. These diseases are also likely to stigmatise or shame the bearer, i.e., to change the identity for the worse. This is in line with other studies, where control and autonomy is demonstrated to be essential for elderly people's self-esteem.

Activities of Daily Living↗
PubMed1997

Increased expression of c-jun, but not retinoic acid receptor beta, is associated with F9 teratocarcinoma stem cell differentiation induced by polyamine depletion.

alpha-Difluoromethylornithine (DFMO), an enzyme-activated irreversible inhibitor of ornithine decarboxylase, and all-trans-retinoic acid (RA) are known to induce F9 teratocarcinoma stem cell differentiation. Both compounds induce the formation of the same cell type, i.e., parietal endoderm-like cells expressing tissue plasminogen activator and collagen type IV alpha-1. The present study shows that DFMO and RA induce terminal differentiation of F9 cells through different pathways. Thus, retinoic acid receptor (RAR) alpha mRNA is weakly expressed during DFMO treatment, but strongly induced during an early phase of RA treatment. RAR beta mRNA is not detectable in DFMO-treated cells, but very strongly induced by RA and maintained at a high level throughout the differentiative process. RAR gamma mRNA is relatively strongly expressed in untreated control cells and remains at approximately the same level during DFMO-induced differentiation. In RA-treated cells, however, RAR gamma mRNA is rapidly down-regulated and becomes nondetectable during the final course of differentiation. These experiments show that the differentiation of F9 cells into parietal endoderm-like cells does not necessarily involve changes in any of the RAR mRNA subtypes. Even though the steady-state levels of the RAR alpha and RAR gamma transcripts may be sufficient to support the differentiative process, our data clearly show that induction of RAR beta mRNA transcription is neither a prerequisite for F9 cell differentiation, nor an absolute consequence of the elevated c-jun mRNA expression that is consistently observed during the course of parietal endoderm differentiation.

Animals↗
PubMed1995

My family dies from heart attacks. How hypercholesterolaemic men refer to their family history.

Patients often worry considerably about biomedically mild and self-limiting conditions. A previous study on non-selected primary care patients showed that this could be partly explained by frequent associations with cases of serious illness in their family histories. This study further investigated these phenomena in middle aged men with a recent diagnosis of hypercholesterolaemia. Sixty-three out of 453, 35-45-year-old male participants were diagnosed with moderate hypercholesterolaemia (6.5-7.7 mmol/l) in a health survey and received 20-30 minutes of life-style counselling. These sessions were audio-taped, transcribed and analysed with respect to the subjects' references to their family histories. Of the 63 men, 28 (45%) mentioned their family history. The main content category in these talks was perceived threat or risk, comprising the seriousness of the event in the family history on one hand and its believed relevance on the other. Fatal, serious or premature disease was discussed. Prevailing lay knowledge and beliefs about hypercholesterolaemia, risk factors and disease causation seemed to determine what conditions in the family history were judged relevant by the men. Several of the men referred to heredity and several regarded emotional closeness important. In a few cases the event referred to mainly functioned as an illustration or example of lay knowledge and beliefs. This study provides support for the view that the family history can play an important role for how asymptomatic patients interpret their risk factors for disease. This is important for the development of consultation skills.

Adult↗
PubMed1993

The patient's family history: a key to the physician's understanding of patients' fears.

Patients often feel considerably worried by conditions that appear to be biomedically mild to their physicians. Their reaction may be linked to personal experience from cases of severe disease in their family history. In this qualitative study, 30 primary health care patients were interviewed about their definition of their present problem, their fears and associations with their family history. For several patients, the discrepancy between objective signs and fears was linked to cases in their family. Death or threats to life, especially when occurring prematurely, appeared to be significant. The same was true for actual or threatening disability in family members. A condition perceived to have been overlooked also seemed to be important for some patients. These findings may be used to understand patients' rationale for seeking care. The subject should be the theme for further investigation.

Adult↗