Rapid determination of alminoprofen in plasma by high-performance liquid chromatography.
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Biomedical subjects
Publications and source records attributed to A Brouard.
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We are presenting a Mac Intosh--Apple computer program (Excel*) for the aminoglycosides (AG) drug monitoring useful in the following situations: --initiation of an AG's dosing regimen depending on the desired peak and through concentration (AG's pharmacokinetic parameters have been calculated according to the AG's literature values). --an adequate dosing regimen after revision of the patient's parameters (calculated with the observed concentrations). The technique has been validated comparing desired (des. C) and measured concentrations (mes. C). --either at the beginning of the treatment, --or after revision of the individual parameters. In the first case, the correlation coefficient obtained between 14 des C and 14 mes. C is equal to 0.91 and is improved when individual parameters are calculated (0.94).
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Doses and dosing interval of analgesic drugs in renal failure are not always available in the data sheet compendium. The aim of the article is to analyse literature references and to present main pharmacokinetics modifications for each analgesic drug in renal failure. Pharmacokinetics parameters, doses and dosing intervals depending on creatinine concentrations are presented for each drug in a table.