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Biomedical subjects

A Burroughs

Publications and source records attributed to A Burroughs.

6 recordsLinked to original sources
PubMed1992

Adult "idiopathic" extrahepatic venous thrombosis. Importance of putative "latent" myeloproliferative disorders and comparison with cases with known etiology.

The etiology of extrahepatic venous obstruction (EHVO) is unknown in 50% of cases. Recently the presence of a "latent" myeloproliferative disorder has been reported in adults with "idiopathic" EHVO. We evaluated the course of these patients to establish if any putative latent myeloproliferative disorder influenced the clinical course compared to those with a known cause. Among 132 EHVO patients, 78 (59%) had a known etiology, 7 (5%) with an overt myeloproliferative disorder. The "idiopathic" group had 54 patients; 24 (13 men, 11 women) were diagnosed after 15 years of age, (median 38 years, range 17-70) with a median follow up of 96 months (19-372). Only 2 (8%) developed an overt myeloproliferative disorder. These 24 had a similar pattern of bleeding and onset of ascites as those with known cause. In EHVO failure to diagnose a latent myeloproliferative disorder does not influence the course of variceal bleeding, and thus has little prognostic significance.

Adolescent↗
PubMed1990

Portal hypertension and hepatic sinusoidal Ulex lectin binding.

Ulex europaeus 1 lectin (UEA1) has previously been shown to bind to hepatic sinusoidal endothelium in cirrhotic liver. This study was undertaken to determine the relationship between UEA1 sinusoidal binding and hepatic venous pressure gradient in patients with portal hypertension. Twenty one liver specimens (including 18 from patients with alcoholic cirrhosis) biopsied within an interval of 1 month from the hepatic venous pressure study were examined for UEA1 binding. The consistent staining pattern of normal liver controls formed the basis for the criteria of positivity and grading system. Seventeen cases (81%) were positive, but the staining intensity or extent showed no strong correlation with the hepatic venous pressure gradient; however, three of the four negative cases were in the low pressure range which is rarely associated with variceal bleeding. We conclude that UEA1 is a useful marker for significant sinusoidal alterations in portal hypertension and a helpful adjunct in the histological diagnosis of cirrhosis.

Humans↗
PubMed1989

Hepatic sinusoidal endothelium: Ulex lectin binding.

The sinusoidal endothelial cells of human liver can be identified by light and electron microscopy, but there appear to be no specific immunocytochemical markers of these cells. Among specific markers available for vascular endothelial cells in general, Ulex europaeus I lectin (UEA I) is the most sensitive. In the present study, 37 liver biopsies were examined for UEA I binding and for Factor VIII related antigen (F VIII RAg) to determine if sinusoidal endothelial cells were positive. The material included normal liver, biopsies from patients with cirrhosis and biopsies in a variety of other liver diseases. Three embryonal human livers were also included in the immunocytochemical analysis. Eleven oesophageal rings obtained at mechanical transection for variceal bleeding in cirrhotic patients were used as control tissue. Sinusoidal endothelial cells of normal liver did not stain with UEA I, but six of seven with alcoholic cirrhosis and only one of 25 non-cirrhotic liver specimens (a case of acute hepatitis with bridging necrosis) were positive. In two of the six cirrhoses the sinusoidal endothelial cells were stained for F VIII RAg as well. Embryonal sinusoidal endothelial cells were stained with UEA I but were negative for F VIII RAg. The results of the study confirm that sinusoidal endothelial cells of normal adult human liver are phenotypically different from those lining blood vessels in other sites. In cirrhosis, positive staining may be related to the transformation of hepatic sinusoids into true capillaries and thus be a marker of the severity of physiological disturbance in the liver.

Antigens↗
PubMed1985

Outcome of diabetic pregnancies in Waikato: five year experience.

The outcome of diabetic pregnancies in Waikato Hospital from 1979-1984 was reviewed. Overall perinatal mortality in the 61 deliveries was 69/1000 births but in the 38 deliveries whose antenatal care included close diabetic control, the perinatal mortality was 26/1000 births. The national perinatal mortality has improved from 12.2/1000 births in 1979 to 9.6/1000 in 1983 (provisional) with an overall rate of 11.0/1000 births. Improved outcome of diabetic pregnancies both in terms of reduced perinatal mortality and reduced neonatal and maternal complications depends on meticulous blood glucose control throughout pregnancy.

Adult↗
PubMedDate not supplied

Hospice thoughts.

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