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Biomedical subjects

A Burssens

Publications and source records attributed to A Burssens.

At least 19 recordsLinked to original sources
PubMed1995

Prevention of heterotopic ossification with tenoxicam following total hip arthroplasty: a double-blind, placebo-controlled dose-finding study.

The effect of tenoxicam 10 mg and 20 mg, administered daily for 6 weeks to prevent heterotopic bone formation after total hip arthroplasty, was evaluated in a randomized, double-blind, placebo-controlled trial involving 90 patients. After 3 months, patients who had received the active drug, including those who had received only half the recommended anti-inflammatory dosage, had significantly less heterotopic bone formation. After 6 months the difference between treatment groups and placebo became smaller but remained significant. Adverse reactions occurred in only 3 patients, reflecting no differences between the groups. The study results, including radiographic, clinical and biochemical evaluations, demonstrate that treatment with tenoxicam 20 mg daily and even with tenoxicam 10 mg daily for 6 weeks, starting immediately after total hip arthroplasty, is effective in preventing ectopic bone formation.

Adult↗
PubMed1993

Osteogenic sarcoma in children. A retrospective study of 58 cases.

Fifty-eight children between age 6 and 18 years were treated for osteogenic sarcoma in the period 1962 to 1987. Fifty-one patients with no preoperative pulmonary metastases (group A) had an overall 5-year survival rate (T5) of 41%; they were subdivided into three subgroups. In subgroup A1 treated with surgery and/or radiotherapy (15 cases), the 5-year survival rate (T5) was 33.3%, as in the classical historical series. In subgroup A2 treated with surgery and postoperative chemotherapy (19 cases) the T5 was 38.8%. In subgroup A3 treated by surgery and pre- and postoperative chemotherapy (17 cases) the T5 was 66.6%, which was statistically the best therapy (p < 0.5). This confirms the general trend in orthopedic oncology. Further data proved the negative prognostic value of male sex, while the grade of tumor and the surgical margins were important factors, but not statistically significant. Seven patients with preoperative metastases (group B) had a T5 of 0%.

Adolescent↗
PubMed1992

Simple bone cysts. A review of 59 cases with special reference to their treatment.

In a retrospective study, 21 simple bone cysts (SBC) treated by curettage (with or without bone grafting) are compared to 20 SBC treated by intralesional injections of methylprednisolone. Curettage led to 43% favourable results and 29% recurrences. Cortisone injections led to 90% favourable results and 5% recurrences. Combined therapy (curettage and injections) led to results comparable to injections only. In our experience, curettage and hydroxyapatite grafting led to 100% complete healing (only 2 cases). We recommend intralesional methylprednisolone injections because the method is easy, effective and safe.

Adolescent↗
PubMed1987

Long-term study of the peroperative infection rate in 1007 total hip replacements using prophylactic cefamandole and other precautions.

Of 1824 primary total hip replacements performed between April 1, 1979, and December 31, 1983, 1007 were reviewed at regular interval and provided sufficiently complete data with special emphasis on pre- and postoperative bacteriological examination and pre- and postoperative determination of the erythrocyte sedimentation rate. All patients with known superficial and deep infections were included. In all cases 2 g of cefamandole q.i.d. were administered within a 24-h period starting with the induction of the anesthesia. All procedures were performed in operating rooms equipped with a vertical laminar air flow. Other precautions included the use of Charnley gowns with a body exhaust system, special draping of the patient, and preoperative culture of the urine. As of June, 1981, gentamicin-loaded polymethylmetacrylate was used routinely. When positive cultures were found in the swabs taken from the tissues during the surgical procedure, appropriate antibiotics were started if the patient was still hospitalized. Follow-up showed two deep (0.2%) and four superficial infections (0.4%). Host factors may play a more important role than suspected, since one patient with a deep infection suffered from severe rheumatoid arthritis and the other from diabetes. Both these patients underwent bilateral hip replacement, the second intervention following the first within 5 weeks. In these two patients the deep infection became apparent 5 and 9 months after the second procedure. Only one of these patients developed a sinus (Staphylococcus aureus).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1982

Pregnancy and post-pregnancy avascular necrosis of the femoral head.

Nine cases in the literature and seven patients in our series with hipache due to avascular necrosis of the femoral head have been reviewed. The onset of symptoms is related to pregnancy. The high adenocortical activity during pregnancy is invoked as a possible explanation of pregnancy avascular necrosis of the femoral head. Maternal parathyroid gland hyperplasia and the elevated parathyroid hormone during pregnancy may play an additional adverse effect on bones. Mechanical stress, due to a difficult labour or excessive weight gain during the last trimester of pregnancy, may be another aetiological factor.

Adult↗
PubMed1982

Dynamics of growth hormone secretion in patients with osteoporosis and in patients with osteoarthrosis.

Basal plasma growth hormone levels as well as growth hormone levels during insulin -induced hypoglycemia have been studied in 19 cases with osteoporosis, in 34 patients with primary osteoarthrosis and in 19 control subjects. Women with primary osteoarthrosis had basal growth hormone levels significantly higher than control patients and patients with osteoporosis. The respective mean values and SE were: 4.9 +/- 0.8 vs. 1.9 +/- 0.8 and 1.3 +/- 0.2, p less than 0.025. During insulin-induced hypoglycemia the growth hormone levels rose to values which in osteoarthrotic women were significantly higher than in osteoporotics and in control subjects.

Aged↗
PubMed1982

Patellar tendinitis: pathology and results of treatment.

Patellar tendinitis can be considered as an overload lesion in athletes. Anatomical pathology reveals focal degeneration and microtearing at predisposed areas near the insertion of the quadriceps or patellar tendon. Thie prognosis and treatment are dependent on the stage of the affection. A program of conservative treatment is effective in the early stages of the disease but it fails in a high proportion (16/38) of cases in the later stages. Surgery directed towards the tendon, rather than a bony procedure, yielded favourable results in 27 out of 29 patients.

Adolescent↗
PubMed1980

Long term follow-up results of a femoral megaprosthesis. A review of thirteen patients.

A total of 16 patients were treated with a femoral megaprosthesis at the University Hospital of Pellenberg. Their charts were reviewed and 13 patients were seen for a follow-up study. The indications for this procedure were revisions of a total hip arthroplasty and primary bone tumors. The aspects of the operative technique and postoperative management are discussed. A careful reconstruction of the abduction apparatus and a post-operative immobilisation for a period of 3 months seems to be important to prevent post-operative dislocation and to obtain an adequate functional result. The operation seems to be successful regarding the absence of pain and a restored function.

Adult↗
PubMedDate not supplied

Materials, clinical and morphological evaluation of custom-made bioreactive-glass-coated canine hip prostheses.

Bioreactive-glass-coated hip prostheses were implanted in dogs for periods of time ranging from 3 to 17 months. The prostheses were tailor-made for each animal through the use of standard radiographs. However, such a procedure does not necessarily yield a close apposition between the glass layer and bone. As a result, the initial stability of the component can be lost before bone bonding is established. Secondary to this phenomenon, the micromotion can lead to a continuous disruption of the top film on the glass despite the evidence of various reaction layers on the glass surface.

Animals↗
PubMedDate not supplied

Case report: massive osteolysis in a case of rheumatoid arthritis: clinical, histologic and biochemical findings.

A 54-year-old male with a 10-year history of seropositive rheumatoid arthritis subsequently developed generalized osteoporosis, multiple cervical spine subluxation, vertebral collapses, and massive osteolysis of the humeral and femoral heads and carpal bones. These lesions were accompanied by neurologic manifestations in both the upper and lower extremities. Bone matrix collagen and noncollagenous proteins in this rare syndrome were analyzed. The pathogenesis of this rare phenomenon is discussed.

Arthritis, Rheumatoid↗
PubMedDate not supplied

Patellar tendinitis (jumper's knee).

A jumper's knee is an overload lesion of patellar or quadriceps tendon near its insertion at the lower or upper pole of the patella. If conservative treatment fails, an operation can be performed in Phase 3 where disabling symptoms, are present. The necrotic tissue in the patellar tendon is excised. The early results of this surgery are encouraging.

Humans↗
PubMedDate not supplied

Surgical treatment of the iliotibial band friction syndrome.

A selected group of 23 patients underwent surgery for iliotibial band friction syndrome. Among the patients presenting with this exertional pain syndrome were runners, football players, and cyclists. Diagnosis was clinical since radiographs were negative and an ultrasound examination was positive in only one case, showing an aberrant picture around the lateral femoral epicondyle. Although conservative treatment is effective in most cases, an alternative is needed for patients with complaints that are resistant to conservative means. Surgery was done with the knee held in 60 degrees of flexion and consisted of a limited resection of a small triangular piece at the posterior part of the iliotibial band covering the lateral femoral epicondyle. The uniform good results, low morbidity, and quick return to sports demonstrate that this type of surgery offers a solution for selected cases of failed prolonged conservative treatment.

Adult↗